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Biomedical subjects

H Toma

Publications and source records attributed to H Toma.

At least 307 records · Page 17Linked to original sources
PubMed1985

Immunohistological evidence for renin in human endocrine tissues.

The peroxidase-labeled antibody method and the avidin-biotin-complex method with antiserum to purified human kidney renin were used to identify renin in human endocrine tissues. Renin immunoreactivity was found in some large cells of the anterior pituitary, the zona glomerulosa and the zona reticularis of the adrenal, the Leydig cells of the testis, and the follicular epithelial cells of the thyroid and prostate glands. The specificity of the immunohistochemical reaction was confirmed by immunoabsorption tests. The specific localization of immunoreactive renin in each tissue suggests a possible role of renin in the function of these tissues.

Adrenal Glands↗
PubMed1985

Evidence for the existence of des-Asp1-angiotensin II in human uterine and adrenal tissues.

Renin is present in various tissues outside the kidney. In contrast, the levels of angiotensins (ANG), the active products of the renin-angiotensin system, have not been thoroughly evaluated in tissues. In this study, we demonstrated the presence of immunoreactive (ir) ANG I and ANG II in various human tissues by RIA. Of the tissues examined, uterine tissue contained the most ir-ANG II. Since the anti-ANG II antibody used had significant cross-reactivity with ANG III, high performance liquid chromatography was performed to separate ANG II from ANG III. The major portion of the ir-ANG II in the plasma was ANG II. In contrast, the major portion of the ir-ANG II in uterine tissue was determined to be ANG III, a known biologically active peptide. The adrenal gland and testis also contained ANG III. From these results, it can be postulated that ANG III may contribute to the biological activity of ANG in some tissues.

Adrenal Glands↗
PubMed1984

[A case of sclerosing lipogranuloma].

Although sclerosing lipogranuloma is relatively rare, it is of special interest to urologists because the majority of the cases occur in the genital and urinary tracts. A 49-year-old man complained of urinary frequency and lower abdominal pain. IVP examination revealed compression and irregularity of dome of bladder. CT scan showed giant abnormal mass upper dome of bladder. The tumor and part of the bladder which was adhered to it were excised. Histological findings were necrosis of the fat cells with liberation of fat droplets into the intercellular spaces. There were giant cells clinging to fatty masses and small fat vacuoles in them. Essentially sclerosing lipogranuloma is a disease affecting the fat cells which for some unknown reason undergo a degenerative type of change which results in rupture of the cells with liberation of free fat droplets into the surrounding intercellular spaces and then reaction around. Complete surgical excision is the treatment of choice. Otherwise the lesion recurs.

Granuloma↗
PubMed1977

Clinical experience with circumferentially reinforced expanded polytetrafluoroenthylene (E-PTFE) graft as a vascular access for haemodialysis.

Circumferentially reinforced E-PTFE grafts were implanted 50 times in 46 patients. Seven grafts became occluded during the observation period of 233 patient-months. Puncture and haemostasis were quite satisfactory in the majority of the patients. Histologically, the inner surface of the grafts was covered with a thin fibrin layer. Puncture sites were stuffed with fibro-fibrinous tissue preventing bleeding or aneurysmal dilatation. Clinical experience has proved the E-PTFE graft to be a suitable vascular prosthesis for blood access.

Adolescent↗
PubMedDate not supplied

Prevalence of urinary tract infection during outpatient follow-up after renal transplantation.

Seven hundred and twenty-seven renal transplant patients are reviewed with respect to the occurrence of urinary tract infection (UTI) after renal transplantation. UTI was defined as the detection of both bacteriuria (10(5) CFU/ml) and pyuria (10 leukocytes/hpf). UTI developed in 11 of the inpatients (20.8%) and in 30 (4.2%) of the outpatients during a one-year period. Among outpatients, 12 had symptomatic infections, comprising seven with acute pyelonephritis and five with acute cystitis. Asymptomatic UTI was detected in 18 patients. In addition, asymptomatic bacteriuria without pyuria was observed in ten (1.4%) patients. UTI was more common in patients with diabetes, and underlying urinary tract complications were present in some patients. Administration of trimethoprim-sulfamethoxazole for about 4 months is suggested to reduce the frequency of UTI in the early period after renal transplantation.

Anti-Bacterial Agents↗
PubMedDate not supplied

Gelatin particle indirect agglutination test for mass examination for strongyloidiasis.

An indirect agglutination test using recently developed gelatin particles was assessed to determine its applicability as a screening test for mass examination for strongyloidiasis. 1199 individuals in Sashiki Town, Okinawa Island, were screened by the test and 34.7% were determined to be antibody positive. Follow-up examination of the persons whose sera showed positive antibody responses demonstrated the presence of faecal larvae in 41.7%. The calculated infection rate (14.5%) was similar (14.1%) to that indicated by another survey using the micro-enzyme-linked immunosorbent assay (micro-ELISA), conducted simultaneously among the inhabitants. The indirect agglutination test was simple to perform in a short time and without specialized equipment. Additionally, the gelatin particles have many advantages as an antigen carrier, e.g. in handling, reading of the resulting pattern, and stable, long-term preservation. The test was considered to be more convenient than the micro-ELISA for mass screening for strongyloidiasis.

Adult↗