[Clinical evaluation of the gastric cancer patients with favorable prognosis].
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Adult↗
Biomedical subjects
H Tokuyama
Publications and source records attributed to H Tokuyama.
[Clinical specificity of gastric sarcoma].
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Age Factors↗
On the active site of myosin A-adenosine triphosphatase. VII. Effect of trinitrophenylation of myosin on the decomposition of phosphoryl myosin.
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Adenosine Triphosphatases↗
On the active site of myosin A-adenosine triphosphatase. VI. Existence of asparaginyl-prolyl-prolyl-lysine near the active site.
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Adenosine Triphosphatases↗
Retinoic acid and steroid hormones regulate IgA production by LPS-stimulated murine spleen cells.
We examined the regulatory effects of steroid hormones (beta-estradiol and glucocorticoids) on in vitro IgA production. Addition of retinoic acid (RA, 100-500 nM) to the LPS-stimulated spleen cell culture enhanced IgA production (8-22-fold). Simultaneous addition of beta-estradiol, but not testosterone, enhanced the effect of RA synergistically (a further 2-4-fold). In contrast, glucocorticoids inhibited the reaction. The concentration inhibiting IgA production by 50% was 1 nM, 6 nM and 10 nM for dexamethasone, prednisolone and hydrocortisone, respectively. None of the hormones tested alone affected IgA production by LPS-stimulated spleen cells. Hydrocortisone enhanced the IgG1 production by LPS-stimulated spleen cells. This effect was completely abolished by simultaneous addition of RA. These findings indicate that RA can direct the class-switching to IgA in LPS-stimulated spleen cells, and that beta-estradiol and glucocorticoids have positive and negative regulatory effects, respectively, on the IgA production.
Animals↗