Search PubMed⌕ Search

Biomedical subjects

H Thompson

Publications and source records attributed to H Thompson.

At least 235 records · Page 13Linked to original sources
PubMed1978

Selection of patients for bile diversion surgery: use of bile acid measurement in fasting gastric aspirates.

Eighteen patients with dyspepsia and vomiting which followed surgery for peptic ulcer have completed a study to examine the role of diverting bile from the stomach by a Roux-en-Y procedure. Bile regurgitation and mild epigastric pain relieved by vomiting were abolished. Measurements of bile acids in the fasting gastric aspirate were useful in predicting the outcome of surgery; good results were obtained when initially there was reflex into the stomach of more than 120 mumol/hour of bile acids. A wider group of patients than those selected in previous series may benefit from this operation, as good results can be obtained in patients with dyspepsia relieved by alkali and without achlorhydria or gastritis. Endoscopy was repeated one year after Roux-en-Y operation. Erythema of the mucosa was improved, but gastritis did not improve.

Adult↗
PubMed1978

Vaccination against Bordetella bronchiseptica infection in dogs using a heat-killed bacterial vaccine.

A group of eight-week-old dogs was inoculated with a heat-killed suspension of Bordetella bronchiseptica by the intramuscular route on two occasions at an interval of two weeks. All vaccinated animals developed high circulating agglutinin titres by two weeks after the second inoculation at which time the vaccinated dogs and a comparable group of unvaccinated animals were challenged by exposure to an aerosol of live B bronchiseptica. Both vaccinated and unvaccinated dogs subsequently developed clinical respiratory disease characterised by persistent coughing but the onset of disease in vaccinated animals was delayed by up to five days when compared with the controls. B bronchiseptica was isolated from the nasal cavity, tracheobronchial tree and lung parenchyma of vaccinated and control dogs.

Animals↗
PubMed1978

Vaccination against canine bordetellosis using an aluminum hydroxide adjuvant vaccine.

Six collie dogs, eight weeks old, were inoculated intramuscularly with an aluminium hydroxide adjuvanted preparation of killed Bordetella bronchiseptica; the inoculation was repeated after two weeks. Two weeks after the second inoculation, the vaccinated dogs and a comparable group of six unvaccinated animals were challenged by exposure to an aerosol of pathogenic B bronchiseptica. All six unvaccinated control dogs developed respiratory disease characterised by persistent coughing. In contrast, four of the vaccinated dogs remained free from clinical respiratory disease while, in the other two dogs, disease was less severe and of shorter duration than in controls. At necropsy, there were only slight changes in the lungs of vaccinated dogs but in controls there was a severe tracheobronchitis with areas of exudative pneumonia. Bacteriological examination showed a marked reduction in the numbers of B bronchiseptica isolated from the respiratory tract of vaccinated animals compared with controls. An aluminium hydroxide adjuvant vaccine may be of value in controlling naturally occurring respiratory disease in dogs in which B bronchiseptica is involved.

Adjuvants, Immunologic↗
PubMed1977

Salmonellosis in young calves due to Salmonella enteritidis.

The clinical and epidemiological features of an outbreak of salmonellosis due to Salmonella enteritidis in a group of calves are described. The major clinical signs were dullness, pyrexia and diarrhoea. Five of the 15 calves died but deaths were mainly confined to the younger members of the group. The recovery of salmonella organisms from rectal swabs was maximal shortly before four of the five deaths occurred and declined rapidly thereafter. Only two of the surviving 10 calves developed significant flagellar agglutination titres.

Agglutinins↗
PubMed1977

Phenytoin toxicity: a fatal case in a dog with hepatitis and jaundice.

Pheyntoin (Epanutin: Parke, Davis) is widely used for the control of chronic convulsive disorders in the dog because it exerts an anti-epileptic effect without causing general depression of the central nervous system. To our knowledge fatal cases of phenytoin sensitivity in the dog have not been reported. A case is described in which hepatitis, jaundice and death followed the administration of the drug.

Animals↗
PubMed1977

Hydrotalcite in the treatment of bile vomiting.

Seventeen patients have completed a double-blind cross-over study of hydrotalcite against placebo in the treatment of bile vomiting after surgery for peptic ulcer. Overall there was no significant difference between the two treatments, with 9 patients improving on hydrotalcite and 5 on placebo. The original operation had been peformed less than 3 years before the study in 9 patients; in this subgroup there was an improvement on hydrotalcite treatment in 8 patients but in only 1 on placebo. These differences are statistically significant (P less than 0.005). Nausea, vomiting, heartburn and epigastric tenderness were improved although gastritis and endoscopic changes were not affected. It appears that hydrotalcite can help palliate symptoms of bile vomiting occuring soon after surgery for peptic ulcer.

Adult↗
PubMed1976

Experimental respiratory disease in dogs due to Bordetella bronchiseptica.

Young dogs of two age groups, six weeks and 12 weeks respectively, were infected by aerosol with a strain of Bordetella bronchiseptica which had been isolated from a dog with pneumonia. Clinical respiratory disease characterised by coughing and in some cases purulent nasal discharge was induced in both groups of infected dogs and also in dogs kept in contact. B bronchiseptica was recovered from the nasal cavity, trachea, bronchi and lung parenchyma of infected and contact animals. At necropsy, masses of Gram-negative bacteria were found trapped in the cilia of the respiratory epithelia and there was an exudate containing neutrophils in the mucosae of the respiratory tract at all levels. A close similarity was noted between the lesions produced in the dog and those described in pertussis infection in man. Experimental respiratory disease in the dog due to B bronchiseptica may offer a model system for the study of the human disease.

Animals↗
PubMed1975

Clinical studies with dopamine-receptor stimulants.

Oral administration of ET-495 was found to cause worsening of psychiatric status in 4 out of 7 schizophrenic patients, and to induce a paranoid state and a syndrome of auditory hallucinosis in 2 non-schizophrenics. These observations were compatible with the hypothesized role of dopamine in schizophrenia. However, these psychotogenic effects were far less dramatic than those noted in other studies with amphetamine, methylphenidate or L-Dopa. Possible explanations for this differing psychotogenic potency of receptor stimulators versus presynaptic agonists are presented. Intravenous ET-495 and apomorphine did not show psychotogenic effects.

Adult↗
PubMed1975

Psychoactive drugs in mania. A controlled comparison of lithium carbonate, chlorpromazine, and haloperidol.

Lithium carbonate, haloperidol, and chlorpromazine hydrochloride were compared in a double-blind controlled study with severely ill hospitalized manics. Lithium carbonate and haloperidol produced a highly significant improvement of manic symptoms without sedation. Although producing considerable sedation, chlorpromazine did little to alter the underlying mania qualitatively. Qualitative differences between lithium carbonate and haloperidol indicate that, while haloperidol has a more dramatically rapid impact on behavior-motor activity, lithium carbonate acted more evenly on the entire manic picture, with total normalization realized during active treatment. The majority of lithium carbonate-treated patients met discharge criteria at study termination, but not the patients receiving either neuroleptic drug. The rating scales are not sensitive enough to monitor manic psychopathology; this accounts for the lack of statistically significant differences among drug groups at treatment termination, despite the widely disparate discharge rates.

Adult↗