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Biomedical subjects

H Terao

Publications and source records attributed to H Terao.

95 records · Page 6Linked to original sources
PubMedDate not supplied

Capability of questionnaire of social and psychological factors to predict coronary heart disease and stroke.

It is well known that the incidence of stroke is higher in Japan than in the US, and that, conversely, the incidence of heart disease is higher in the US than in Japan. To clarify this fact, a socio-cultural investigation is indicated. This study was therefore conducted from that viewpoint. A questionnaire was devised and a survey conducted to investigate the effect of social, cultural, and psychological factors on coronary heart disease and stroke. The survey was based on the hypothesis that cultural differences between Japan and the US contribute heavily to differences in the incidence of stroke and heart disease between the two countries. The questionnaire was analysed and correlated with physical examination findings, using Hayashi's quantification method type II. Discrimination between two distinct groups for each disease was clear and the predictive capability of the questionnaire was thus ascertained. In this report we concentrated on use of the prediction table use of sample data, and prediction of the probability of abnormality.

Adult↗
PubMedDate not supplied

Evidence for the presence of fatty acid methyl esters in human hepatoma tissue from a patient with hypercholesterolemia.

The lipid composition of a human hepatoma tissue (liver cell carcinoma) was examined by thin-layer chromatography (TLC), and an unusual lipid spot was found in a large quantity. It was identified as consisting of fatty acid methyl esters by TLC and gas chromatography-mass spectrometry techniques. In the fatty acid methyl ester fraction, oleate (18:1) and palmitate (16:0) were dominant. Furthermore, very unusual fatty acid methyl esters, such as methyl 2-methyl oleate, were detected. These unusual lipids could be detected neither in cirrhotic lesions of the host liver nor in normal control tissues.

Carcinoma, Hepatocellular↗
PubMedDate not supplied

The augmenting effect of OK432-stimulated B cells on the in vitro generation of anti-tumor cytotoxic T lymphocytes from tumor-draining lymph node cells: the possible role of interleukin-12.

Effect of a local injection with a streptococcal preparation OK432 on the in vitro generation of anti-tumor cytotoxic T lymphocytes (CTLs) from tumor-draining lymph nodes (LN) was investigated. A peritumoral injection with OK432 on days 2, 4, 6 and 8 significantly increased both the total cell number and the proportion of B cells in the draining LN cells on day 10 after a subcutaneous inoculation with B16 melanoma. In an in vitro proliferative assay, OK432 showed a stimulatory effect on both normal splenic T and B cells. In a cytolytic assay, the OK432-injected B16-draining LN cells showed a higher level of anti-B16 CTL activity than the B16-draining LN cells after in vitro restimulation. This augmenting effect of OK432 was dependent on the B cells. Moreover, nonadherent cells from the OK432-injected B16-draining LN cells showed a low but significantly higher level of anti-B16 CTL activity than those from the B 16-draining LN cells after in vitro restimulation, whereas this augmenting effect of OK432 was abolished by the in vitro addition of anti-interleukin (IL)-12 monoclonal antibody. Collectively, these findings suggest that the augmenting effect of a local injection with OK432 on the potential of tumor-draining LN cells to turn into anti-tumor CTLs after in vitro restimulation was at least in part due to IL-12 derived from the OK432-stimulated B cells.

Animals↗