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Biomedical subjects

H Teichmann

Publications and source records attributed to H Teichmann.

At least 19 recordsLinked to original sources
PubMed1989

[Psychological reflections by adolescents on the atomic threat].

The results are focussed on the three most important wishes and fears of 247 adolescents aged 14 years whose development is being followed from birth in the framework of the Rostock Longitudinal Study. The peace/war problem occupies a central position in the thinking of adolescents today. However there are no indications that the individual perception of and reflection on the nuclear threat impair psychic development nor is there any relation between political fears and the anxiety trait. The extension of personal wishes and fears to broader fields of significance and the facing up to world problems constitute signs of a maturing personality and a widened consciousness of reality. Psychic coping of such global fears will be facilitated the more the individual gains personal experience of the effectiveness of peace policies and activities--not least by making his/her own contribution.

Adaptation, Psychological↗
PubMed1985

Coincident change of cellular function and phenotype in the course of a suppressor T cell acute lymphocytic leukaemia.

The phenotypic and functional characteristics of the leukaemic cells from one patient with T suppressor ALL were studied at the time of diagnosis and in relapse. At the time of diagnosis, the phenotype corresponded to the intermediate stage between the cortical and medullary phases of normal thymocyte differentiation with a high proportion of T8+ cells (E-R+, TdT+, C3bR-, T3-, T4-, T6+, T8++, T10+). Functionally, the cells did not respond to mitogens but mediated strong suppressor activity to allogeneic B-cells, as measured in a reversely haemolytic plaque test. Clinically, the patient exhibited the uncommon feature of hypogammaglobulinaemia. Induction therapy led to complete remission, which continued for 12 months. In the relapse, the phenotype remained essentially stable except for a dramatic decrease of the T8+ cell fraction and an increase of the T10+ cell fraction. Functionally, the suppressor activity was completely lost, indicating a close correlation between phenotype and functional activity in this leukaemic cell population.

Adult↗
PubMed1985

[Effect of psychosocial risks on the maturation of EEG background activity in early childhood brain-damaged children].

Age-dependent changes in EEG activity were assessed in a comparison of EEG recordings taken from 102 children at the ages of 6 and 10 years. Of the 2-to-13-cycle-a-second activity recorded from the left occipital region, the fast alpha frequencies (10 to 13 cycles a second) showed a significant increase at the expense of all slower frequencies. The children were divided into two groups according to whether they had been exposed to a small or large number of biological risks; in the latter group the extent of the increase in fast alpha activity was negatively related to the number of additional psychosocial risks. This effect was even more pronounced in the group of brain-damaged children, where the smallest age-dependent shift in the EEG frequencies was seen in the group with both minimal brain damage and a high psychosocial risk factor. These data suggest that the exposure of children with minimal brain damage to multiple psychosocial risks may lead to a delay in the maturation of the brain that can be detected by neurophysiological methods.

Alpha Rhythm↗
PubMed1984

Ph1 positive blast crisis of chronic myeloid leukaemia exhibiting features characteristic of early T blasts.

Leukaemic cells from a patient in the blast crisis of chronic myeloid leukaemia were subjected to a surface marker analysis using a panel of monoclonal antibodies recognizing differentiation antigens of myeloid (MY7, MY906, VIM D5, M phi P9), erythroid (VIE G4), megakaryocyte (AN51), T-lymphoid (WT1, 10.2, OKT3, OKT4, OKT6, OKT8, OKT11A) and B-lymphoid cells (B1, B2, Y29/55), common ALL-antigen (VILA1), non-lineage-restricted antigens (OKT9, OKT10), monomorphic HLA-DR determinants (7.2) as well as TdT. When the patient entered his first blast crisis, his blasts expressed a phenotype corresponding to an immature myeloid cell (7.2+, MY7+, My906+, VIM D5-). Ph1-chromosome-positive blasts from this patient's first relapse had completely changed their surface marker characteristics: they had become TdT-positive and exhibited surface features characteristic of early T blasts (WT1+, 10.2+, OKT9+, OKT10+, 7.2-, OKT6-). Together, these features provide evidence that myeloid cells may share a common precursor with T cells.

Adult↗
PubMed1984

Abnormalities of B-cell activation and immunoregulation in patients with Crohn's disease.

We have studied B-lymphocyte function in 39 patients with Crohn's disease and 35 normal individuals using a reverse haemolytic plaque assay as the effector system. Ten patients had active Crohn's disease, the others being in an inactive state of the disease. Compared with normal individuals, the Crohn's disease patients - especially those in the active state of the disease - had markedly raised numbers of spontaneous immunoglobulin secreting cells and severely decreased responses to the polyclonal activator pokeweed mitogen. The differences between the reactivity of patients with active disease and those with inactive disease were statistically significant. These findings indicate an in vivo polyclonal B-cell activation in Crohn's disease patients, possibly due to antigen(s) or infectious agent(s). In vitro experiments were performed with separated lymphocytes in order to characterise the mechanism responsible for the altered immune reactivity in Crohn's disease. These revealed an intrinsic B-cell defect as well as an impaired T-helper cell capacity in patients with Crohn's disease. Findings supporting the hypothesis of an increased suppressor activity in Crohn's disease patients could not be observed, and marker analyses revealed normal proportions with the exception of raised Leu 7 positive cells that mediate 'natural killer' and 'killer' cytolysis. We conclude that immune dysfunction in peripheral blood lymphocytes of Crohn's disease patients involves B-cells as well as T-helper cells.

Adult↗
PubMed1980

Stimulation of regulatory T cell circuits by immunoglobulin-dependent structures on activated B cells.

An immunoregulatory circuit is described in which B cell blasts activate syngeneic Ly-1+2-3- T cells to (a) start a reaction which is indistinguishable from a graft-vs.-host reaction (syngeneic GvH) and (b) induce suppressor cell activity which abrogates the syngeneic GvH. Since capping the surface immunoglobulin (Ig) on B cell blasts blocks their ability to activate the circuit, it is likely that the relevant cell surface structure "seen" on the B cell by the Ly-1 T cell is either Ig itself or another molecule in association with Ig.

Animals↗
PubMed1979

[Factor structure of psychopathologic symptoms in the pre-school age].

The authors present a factor analysis of 49 psychic and physical peculiarities found in 294 children in creches, most of them high-risk children; these were perinatologically classified at the time of birth, and an examination was performed by neuropsychiatrists and a follow-up clinical and psychological examination made, at the age of 2.0-2.3 years. The following two problems were of interest: 1. Can psychosyndromes be detected in creche children and, if so; 2. Does the psychosyndrome obtained through factor analysis contain vegetative symptoms? Results - The peculiarities can be grouped as follows: (table; see text) This is the first time that the existence of a pre-school chronic psychosyndrome has been detected using a multivariate method. Its basic structure is as described by Göllnitz. A discussion follows of its position within the symptom variability in damaged and disturbed children, and of rough brain localization analogies.

Brain Damage, Chronic↗
PubMed1978

[Attitude of mothers towards physical punishment as a counseling problem in small children with developmental disorders].

Using the questionnaire that has been specifically developed to obtain data on parental educational behavior, 294 mothers of 2-year-old children were studied and their attitudes towards corporal punishment correlated with characteristics and symptoms of children as well as with psychosocial factors. Low level of education and lack of domestic happiness proved to be essential conditions for acceptance of corporal punishment. Children with developmental disorders are especially endangered only because of their particular liability to disorders, but on account of the fact that they do not receive the same amount of clemency as do children who are liable to infections. Problems of maleducation should receive greater attention in the elimination of environmental dangers to healthy development of children as well as in counseling.

Attitude↗