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Biomedical subjects

H Tazaki

Publications and source records attributed to H Tazaki.

At least 163 records · Page 9Linked to original sources
PubMed1989

[Therapeutic guide for renovascular hypertension with reevaluation of surgical treatment].

Therapeutic guide for renovascular hypertension has been greatly changed by a development of beta-blockers and captopril, and an introduction of percutaneous transluminal angioplasty (PTA) The accepted opinion was that surgical therapy was superior to drug therapy since Hunt & Strong reported the follow-up results in 1973. However, efficacy of drug therapy was reevaluated by an appearance of beta-blockers and captopril and the number of patients applied to operation was decreased. Further, since PTA was widely used in clinical practice from the end of 1970s, surgical therapy for renovascular hypertension was hardly or never considered. Has the necessity of surgical therapy really ceased to exist? Recently, we encountered 2 cases of bilateral renovascular hypertension and reevaluated the necessity of surgical therapy during the course of treatment. The first case was in a 43-year-old male, for whose bilateral renovascular stenosis a bilateral PTA was applied. One year later a complete occlusion of the right renal artery and re-stenosis of the left renal artery developed. Thus, removal of the right kidney and the auto-transplantation of the left kidney were conducted. The second case was in a 17-year-old female with bilateral renovascular stenosis complicated by moya-moya disease. PTA was conducted for the left kidney with shorter range of stenosis and auto-transplantation was conducted for the right kidney with longer range of stenosis. The prognosis was favorable in both cases and hypertension was cured or improved. We recognized and re-evaluated the necessity of surgical therapy for patients who were unsuccessful to PTA or patients with bilateral renovascular hypertension from our experience and literatures.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1988

[A case of large cell carcinoma of the lung responding to cisplatin-based polychemotherapy].

A patient with large cell carcinoma of the lung with multiple intrapulmonary metastases has been treated with three courses of cisplatin-based polychemotherapy (cisplatin, adriamycin and peplomycin). He experienced nausea, vomiting, alopecia, and bone marrow suppression as side effects, which proved to be mild, that he tolerated well. A complete response was obtained, and he has been free of disease for more than three years.

Adult↗
PubMed1988

[Oncogenes and oncogene products in urogenital cancer cells].

Recent development in microbiology and genetic engineering has provided the identification and characterization of so-called 'oncogenes'. The concept of oncogenes has much stimulated intense interest in searching the cause of uncontrolled cell growth and factors responsible for formation of tumors. Because of the fact that oncogenes were first discovered in an established cell line derived from patient with bladder tumor, the association between oncogenes and genitourinary cancer has much attention. Variety of pathways of tumor development in bladder cancer can be divided in two major forms, low grade papillary tumor and high grade infiltrating tumor. Activation and a sequence of oncogenes may be relevant to the ultimate expression of these separate pathways. Concept of initiation and promotion may also be factored into these consideration. The application of these principles to the different pathways of tumor development such as in bladder, kidney and prostate cancers, supports the concept that oncogenes may be required to production of malignant tumors. The purpose of this paper is to review recent evidence that has enhanced our understanding of the genetic basis of cancer development in the genitourinary tract cancer.

Aged↗
PubMed1988

[Phase II study of carboplatin in genitourinary cancer. Urological Cooperative Study Group on Carboplatin].

Carboplatin was evaluated in a phase II study involving 109 patients with genitourinary cancer. A total of 21 cases of advanced testicular tumor, 38 of transitional cell carcinoma (TCC) of the urinary tract and 25 of prostatic cancer were evaluable for response. The response rate in testicular tumors was 48%, with 70% in seminomas and 27% in nonseminomas. Three responses were observed in patients previously treated with cisplatin. In TCC, the response rate was 18%. No response was observed in prostatic cancer. Carboplatin was well tolerated with no significant renal impairment and ototoxicity detected. Nausea and vomiting were experienced by 50% of patients but the severity was low. Severe myelosuppression, thrombocytopenia and leukopenia were observed. In conclusion, carboplatin has demonstrated activity in both testicular tumors and TCC of the urinary tract and is worthy of further study, especially in combination with other active drugs.

Adult↗
PubMed1988

[Treatment of oligospermic patients with varicocele].

The management of oligospermic patients with varicocele was reviewed. Varicocelectomy was performed in 46 oligospermic patients with varicocele (group 1) and kallikrein treatment was followed for those who failed to improve the semen quality after varicocelectomy (group 2). Twenty oligospermic patients with varicocele were given kallikrein for over 6 months as an initial treatment (group 3). A significant increase in total motile sperm count was noted in 34.8% of the patients in group 1, 22.7% in group 2, and 30.0% in group 3 respectively. Conception rate which was calculated after excluding couples, in which the partner received either artificial insemination by husband or any gynecological treatment, was 20.8% in group 1, 15.4% in group 2, 25.0% in group 3 respectively. No significant changes in hormonal data was observed after either treatment, but semen quality was not improved in patients who showed high serum level of luteinizing hormone (LH) or follicle stimulating hormone (FSH). Kallikrein is useful for oligospermic patients with varicocele as an initial treatment and for those in whom semen quality was not improved after varicocelectomy. Varicocelectomy and/or kallikrein treatment can be recommended mainly for those who show normal serum level of LH and FSH.

Fertilization↗
PubMed1988

[Studies on KU-1 and KU-7 cells as an in vitro model of human transitional cell carcinoma of urinary bladder].

Cellular characteristics of KU-1 and KU-7 cells after a long term in culture were evaluated for eligibility of in vitro model of human transitional cell carcinoma of the urinary bladder. The KU-7 cells derived from superficial papillary tumor showed small, polygonal and homogeneous cells, while the KU-1 cells derived from a broad basic invasive carcinoma showed a variety in size as well as piling up tendency. The adhesiveness of these cells in culture was examined and a significant difference in their cellular structures, a thick multilayered mass in KU-1 while a thin flat spreading in KU-7, was found by each rotating culture and culture on collagen sponge matrix. KU-7 cells cultured without sera responded to transforming growth factor (TGF-alpha) but KU-1 cells did not show any response to the factor. These findings indicate that KU-7 and KU-1 cells have maintained some basic characteristics of papillary tumors and infiltrating carcinomas, respectively.

Animals↗
PubMed1988

[Elaboration of erythropoietin in cultured cells].

Patients with renal cell carcinoma (RCC) rarely develop erythrocytosis. Mechanism of this phenomenon has been disclosed by a series of recent studies using tissue culture technology that erythropoietin (Ep) elaborated by tumor cells. In this review article, the results of in vivo and in vitro studies using the established cell line KU-2 a nude mouse transplantable strain originated from a patient, T.N., with an Ep producing RCC showing erythrocytosis are introduced and discussed on the mechanism of Ep production by the cultured cells. The cultured RCC cells are eligible to produce Ep at stage of over confluence forming the "domes" which are conceivable as the differentiation of the RCC cells in vitro.

Animals↗
PubMed1987

Flow cytometry based on heterogeneity index score compared with urine cytology to evaluate their diagnostic efficacy in bladder tumor.

Flow cytometric (FCM) examination of DNA distribution based on heterogeneity index score (HIS) and ploidy pattern and of bladder irrigation specimens were compared with conventional urine cytologic examinations to evaluate the diagnostic efficacy of each method. Of 56 patients with histologically proved bladder tumors, 24 (43%) had positive urine cytology, 41 (73%) had positive FCM, and 45 (80%) had positive urine cytology and/or positive FCM. When bladder tumors were graded histologically, 8 of 11 patients (73%) with grade I bladder carcinoma, 22 of 28 patients (79%) with grade II, and 15 of 17 patients (88%) with grade III had positive urine cytology and/or positive FCM. Of the 28 patients with grade II, 12 with positive urine cytologic results had higher mean HIS (117.5) when compared with 16 (61.1) in whom urine cytology was negative. Of those who continued to have positive FCM in the face of negative findings on cystoscopic and urine cytologic examinations during follow-up, 3 patients eventually were found to have tumors (2 distal ureter, 1 bladder). These results indicate that FCM examinations for DNA distribution of bladder irrigation specimens are as useful as conventional urine cytology in the management of bladder tumors, can be more sensitive for detection and monitoring of the disease, and can contribute further to accurate diagnosis of the disease when combined with conventional urine cytology.

Carcinoma, Transitional Cell↗
PubMed1987

Augmentation of cell-mediated cytotoxicity against renal carcinoma cells by recombinant interleukin 2.

The effects of recombinant interleukin 2 (IL-2) on natural killer (NK) cell activity against established renal carcinoma cell lines CaKi 1, KU-2, and freshly prepared renal carcinoma cells were studied. Augmentation of NK cell activity by IL-2 was dose- and time-dependent. The results indicate that the optimal dose of IL-2 was 100 to 500 U/mL, and that cytotoxicity increased significantly even at a low concentration such as 4 U/mL. IL-2 induced significantly higher levels of cytotoxicity against renal carcinoma cells than did gamma-interferon. The influence of IL-2 on lymphocyte subpopulations was then examined using flow cytometry with monoclonal antibodies OKT3, OKT4, OKT8, Leu 7, and Leu 11. The results showed that IL-2 increased the number of cells positive to Leu 11, the so-called active NK cells. We concluded that IL-2 has an important role in the treatment of renal carcinoma.

Carcinoma, Renal Cell↗
PubMed1987

Pre-operative evaluation of the prognosis of hypertension in primary aldosteronism owing to adenoma.

The prognosis of hypertension was evaluated pre-operatively in 40 patients with primary aldosteronism owing to adenoma by examining the severity of hypertension, family history of hypertension, age of the patients, duration of hypertension, plasma renin activity, plasma aldosterone concentration, and efficacy of spironolactone (100 mg per day for 10 days) on blood pressure. In 30 of the 40 patients, the blood pressure was reduced to below 160/95 mmHg within a year after adrenalectomy (responders). In the other 10 patients, the blood pressure was not markedly reduced and remained above 160/95 mmHg (nonresponders). There were no significant differences in the age of the patients, family history of hypertension, plasma renin activity or plasma aldosterone concentration between these two groups. The severity of hypertension as judged by the WHO classification and the duration of hypertension prior to operation seemed to be of some use in assessing the postoperative prognosis of hypertension, but the efficacy of spironolactone was far more useful. That is to say, a reduction in mean blood pressure of more than 15 mmHg after administration of spironolactone was observed in 29 of the 30 responders. The remaining one patient showed an 11 mmHg reduction in mean blood pressure. On the other hand, none of the nonresponders revealed a reduction in mean blood pressure of more than 15 mmHg after spironolactone administration. From these results it is concluded that the pre-operative response of blood pressure to administration of 100 mg per day of spironolactone for 10 days represents a useful indicator of the postoperative prognosis of hypertension in patients with primary aldosteronism owing to adenoma.

Adenoma↗