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Biomedical subjects

H Tauchi

Publications and source records attributed to H Tauchi.

At least 73 records · Page 4Linked to original sources
PubMed1986

Age changes of myofibrils of human minor pectoral muscle.

Micro- and ultramicromeasuring studies have been made on the age changes of surgically resected minor pectoral muscles in 200 Japanese females of various ages (26-80 years). With advancement of age, muscle fibers of type I decreased in number and increased in size, and the age-related increase in size is not considered to be due to an increase in number of myofibrils but seems to be due to an increase in their volume resulting from an increase in the number of myofilaments.

Adult↗
PubMed1985

Fine structural analysis of lipofuscin in various tissues of rats of different ages.

Comparative fine structural analysis of intracellular dense inclusions in various tissues of rats of different ages (2, 11 and 29.5 months old) was made. The majority of dense inclusions observed in 2-month-old rats were of the granular type. With advancing age, granular type inclusions gradually decreased in frequency, while compound type inclusions, such as granular-homogeneous and granular-lamellated type increased except for spleen. In the bronchial epithelia, granular-lamellated inclusions appeared at 2 months of age. On the other hand, in the heart, liver, spleen, and skeletal muscle, lamellated or granular-lamellated inclusions were not observed at any of the three age levels. Dense inclusions seemed to have various patterns of distribution, frequency of appearance, and source of organelles in each tissue and cell. They also did not show the maturity of pigment in the process of pigment formation. These findings suggested that these inclusions were not merely age-related granules, but seemed to be influenced by their relationship to the cell metabolism and other functions.

Aging↗
PubMed1985

Age-related change in brush borders of rat kidney cortex.

Age-related change of rat renal brush borders was examined with electron microscopy and biochemical procedures. Total activity of renal brush border enzymes, such as alkaline phosphatase and leucine aminopeptidase in the homogenate, was significantly decreased with age. Acid phosphatase activity and protein content were not significantly changed with age. Specific activity of leucine aminopeptidase in brush border fraction was significantly decreased at a later stage of age. Protein content of brush border fraction was decreased significantly with age. On sodium dodecyl sulfate-polyacrylamide gel electrophoresis, some of the proteins disappeared during aging. Electron microscopic observations of kidney cortex showed that microvilli of renal brush borders from old rats were observed to be fewer than those from the young; epithelial cells in young rats have more densely packed brush border projections than those in old rats. From these results, it is suggested that during aging renal brush borders are degraded, and that protein components of the brush borders were different between old and young.

Acid Phosphatase↗
PubMed1984

Age changes in size and number of muscle fibers in human minor pectoral muscle.

Micromeasuring studies have been made on the senile changes of the surgically resected minor pectoral muscles in 200 Japanese females of various ages (26-80 years). The microscopic differentiation between type I (red) and type II (white) fibers were made by the histochemically demonstrated myosin-ATPase activity with frozen sections and also by the immunohistochemical demonstration of beta-enolase in the paraffin sections with indirect antibody method. The decrease with age in weight of the muscle was not markedly observed. Muscle fibers of type I were significantly decreased in number and increased in size after 60 years of age. However, size of muscle fibers of type II decreased gradually after 40 years of age. However, size of muscle fibers of type II decreased gradually after 40 years of age. Total volume of type I muscle fibers was not changed according to age, on the contrary, that of the type II fibers decreased significantly after 60 years of age.

Adenosine Triphosphatases↗
PubMed1982

Age changes in human vocal muscle.

Micromeasuring studies have been made on the senile changes of the vocal muscle in 109 Japanese males of various ages (18--97 years). For the microscopic differentiation between red and white fibers, paraffin section were stained with phosphotungstic-hematoxylin. The decrease in number after 50 years of age was similar in both red and white fibers, while the volume of both types of fiber somewhat increased with age. However, a slight difference was recognized in the changes between the red and white fibers. The white fibers significantly decreased in number first in the earlier stage of life, and noticeably decreased in number after 80 years of age, with no appreciable increase in volume. In the red fibers, on the other hand, the decrease in number after 80 years was highly significant, and was accompanied by a significant increase in their volume.

Adolescent↗
PubMed1982

Age changes of mitochondria of rat kidney.

Age-related changes of the mitochondria in the renal proximal convoluted tubules, using 2-, 12-, 18- and 25-29-month-old rats, were morphometrically examined with reference to the mitochondrial function. Mitochondrial volume per cell was significantly larger in 12- and 18-month-old rats compared with that in 2- and 25-29-month-old animals. The total volume of mitochondria in the proximal convoluted tubules was estimated to be maximal in the 18-month-old rats, and decreased significantly in the 25-29-month-old ones; the mitochondrial cristae were arranged most sparsely in the former case and became significantly compact in the latter. The number of epithelial cells in the 25-29-month-old rats was also significantly smaller than in the 18-month-old rats. From the above, in the 25-29-month-old rats, each mitochondrion seems to function more actively to compensate for the numerical loss of cells and their mitochondria.

Aging↗
PubMed1980

Changes in hepatic cell mitochondria during parabiosis between old and young rats.

Electron-micrographic measurement studies have been made on the hepatic cell mitochondria of the long-lived parabiotic unions between old and young rats. The mitochondria of the younger partners were significantly larger in size and those of the older partners were significantly larger in number and smaller in size compared with those of young and old control rats, respectively. The mitochondrial cristae seemed to become more compactly arranged in the younger partners and more sparsely in the older ones. The influence of parabiosis between different aged rats upon age changes in mitochondria and their function is discussed.

Aging↗
PubMed1980

Accumulation of lipofuscin pigment in human hepatic cells from different races and in different environmental conditions.

The changing pattern with age of lipofuscin pigment deposition in the hepatic cells of native and Hawaii Japanese and caucasians in the U.S.A. was micrometrically examined. The amount of pigment was generally largest in the Hawaii Japanese, and smallest in the native Japanese; the age-related increase of the pigment was most marked in the latter. The accumulation of pigment in human hepatic cells is considered to be an age-related change in the hepatic cells, but not necessarily of the individual, and seems to be influenced by a relationship between nutritional conditions and constitution of the individual. Though a possible relationship between age and lipofuscin deposition may be noticed, the accumulation of pigment in the hepatic cells is not necessarily an inherent part of the aging process of the individual.

Adult↗
PubMed1979

Age changes in the livers of Costa Ricans.

Age changes in the livers of Costa Ricans have been compared with those of native and Hawaii Japanese and U.S. caucasians. In the case of the U.S. caucasians and Costa Ricans, the decrease in the number of hepatic cells is similar up to 70 years of age, but after 80 years of age the decrease is more marked in the Costa Ricans. The difference in the process of senile change among these four groups suggests that the environmental, especially nutritional, conditions during their childhood and adolescence play an important role.

Adult↗