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Biomedical subjects

H Taniguchi

Publications and source records attributed to H Taniguchi.

840 records · Page 47Linked to original sources
PubMedDate not supplied

Are both PIVKA-II and alpha-fetoprotein necessary in follow-up management after hepatic resection for hepatocellular carcinoma?

BACKGROUND/AIMS: The aim of this study was to clarify the need for measuring of PIVKA-II (protein induced by vitamin K absence or antagonist-II) and alpha-fetoprotein as the prognostic indicator for patients after hepatic resection for hepatocellular carcinoma, and as the monitoring modality for early detection of recurrence after hepatic resection. METHODOLOGY: One hundred and thirty-one patients who underwent planned liver resections for hepatocellular carcinoma were studied. RESULTS: The survival rates in patients positive for preoperative tumor markers were significantly lower than in those in the negative patients. The first modality leading to the diagnosis of recurrence was measurement of alpha-fetoprotein and/or PIVKA-II in 25 cases (55.6%). Almost all patients (96.6%) with positive preoperative alpha-fetoprotein and recurrence had elevated alpha-fetoprotein again when recurrence was found. CONCLUSIONS: Preoperative PIVKA-II and/or alpha-fetoprotein levels can predict postoperative prognosis. Measurement of these markers is useful in monitoring recurrence. For following up patients with alpha-fetoprotein-producing tumors, alpha-fetoprotein monitoring only is sufficient to detect recurrence.

Adult↗
PubMedDate not supplied

Stimulation by estrogen and progesterone of the in vivo growth of transformed murine Leydig cells only at the limited early phase of growth.

B-1 F is a cell line established from estrogen-responsive murine Leydig cell tumor and maintained in vitro. We investigated the effects of steroid hormones on the growth of tumors produced by the inoculation of B-1 F cells into mice. When tumor tissues were transplanted into castrated male mice, injections of estradiol-17 beta (E2) or progesterone shortened the period before tumors became palpable, but did not affect the growth rates of tumors after tumors became palpable. Injections of E2 or progesterone from the time when tumors became palpable did not affect the growth of tumors, and the discontinuation of injections of E2 or progesterone during the middle growth phase showed no effect on the growth of tumors. E2 or progesterone also did not increase the mitotic indices of tumors after they became palpable. E2 and progesterone did not stimulate the proliferation of dispersed tumor cells in vitro. The present results suggested that steroid hormones might exert their actions only at the limited early phase of growth of transplanted steroid hormone-responsive tumors in vivo.

Animals↗
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Clinicopathological analysis of gastric cancer in young adults.

BACKGROUND/AIMS: Whether gastric cancer in young patients differs in any way from gastric cancer in older patients has been a controversial issue. This study was designed to determine the clinicopathological features of gastric cancer in young patients. MATERIAL AND METHODS: The clinicopathological features of 86 young patients with gastric cancer, defined as 39 years of age or younger, were reviewed retrospectively from hospital records between 1969 and 1993. They were then compared with 1134 middle-aged patients with gastric cancer between 40 and 69 years old. RESULTS: The incidence of gastric cancer in young patients declined from 6.34% of all gastric cancer patients 20 years ago to 4.49% in the most recent decade. The histopathological findings for gastric cancer in young patients were aggressive features, including an undifferentiated type, a scirrhous type, and an infiltrating type (defined as infiltrating growth and an indistinct border from the surrounding tissues). There were no statistical differences in tumor staging and survival between the 2 groups. CONCLUSION: Gastric cancer in young patients decreased in overall incidence, but possesses aggressive histopathological features different from older patients. Furthermore, the tumor staging and prognosis for young patients was similar to middle-aged patients.

Adenocarcinoma↗
PubMedDate not supplied

Weight of resected liver is positively correlated with serum hHGF level.

BACKGROUND/AIMS: Human hepatocyte growth factor (hHGF) is involved in the control of liver regeneration. MATERIAL AND METHODS: We measured serum hHGF levels before and after partial hepatectomy in 43 patients and recorded the weight of the resected liver. RESULTS: Serum hHGF levels increased soon after operation and decreased thereafter. In the noncirrhotic group, the maximum hHGF concentration and the area under the curve of hHGF seven days postoperatively correlated with the weight of the resected liver. CONCLUSION: The amount of injured liver tissue can be approximated by the serum hHGF levels. This calculation can be useful in evaluating cases of hepatectomy, general hepatic injury, liver transplantation, and other types of hepatic damage.

Adult↗
PubMedDate not supplied

Levels of human hepatocyte growth factor (hHGF) in peritoneal fluid after partial hepatectomy.

BACKGROUND/AIMS: Human hepatocyte growth factor (hHGF), now known to be identical with scatter factor and tumor cytotoxic factor, is thought to be involved in the regeneration of the liver in humans. MATERIAL AND METHODS: We measured the levels of immunoreactive hHGF levels in peritoneal fluid before and after partial hepatectomy in 37 patients, 10 with and 27 without cirrhosis. The presence of hHGF was confirmed in human peritoneal fluid with rat hepatocytes in primary culture and Western blot. RESULTS: Levels of hHGF increased significantly in peritoneal fluid after surgery, with its total concentration being correlated with the weight of resected liver 168 hours postoperatively. CONCLUSION: Findings suggest that the hHGF levels in peritoneal fluid may indicate the extent of hepatic damage following partial hepatectomy and other liver diseases.

Adult↗
PubMedDate not supplied

Clinical outcome of surgical treatment for invasive early colorectal cancer in Japan.

BACKGROUND/AIMS: Despite the high frequency of early colorectal cancer, little is known about the clinicopathologic features of invasive early colorectal cancer for which endoscopic polypectomy is not indicated. We wanted to determine the clinicopathologic features of these early colorectal cancers. MATERIALS AND METHODS: From 1973 to 1994, a total of 728 patients with colorectal cancer were reviewed retrospectively from hospital records. The clinicopathologic features of the 90 invasive early colorectal cancer patients who underwent major surgeries were compared with those of 626 patients with advanced colorectal cancer. RESULTS: The frequency of early colorectal cancer increased significantly from the periods 1973-1979 to 1990-1994: 0% in the former period and 18.3% in the later period. Minimally invasive surgery was chosen more frequently for the treatment of early colorectal cancers than for the treatment of advanced cancers (p < 0.005). Lymph node metastasis, lymph vessel invasion, and vascular invasion were more prevalent in advanced cancer cases than in early cancer cases (p < 0.005). Lymph node metastasis was found in 7 patients with early colorectal cancer (7.8%). There was no difference in histologic type between the early and advanced colorectal cancers. The 5-year survival rates of early colorectal cancer patients were higher than those of advanced cancer patients: 97.5% in early colon cancer patients; 93.5% in early rectal cancer patients; 59.8% in advanced colon cancer patients; 55.4% in advanced rectal cancer patients. Three early colorectal cancer patients died of recurrence. CONCLUSION: Minimally invasive surgery such as laparoscopic colectomy should be performed on patients with invasive early colorectal cancer when it is impossible for the cancer to be removed by endoscopic polypectomy.

Aged↗
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Clinicopathologic features of synchronous multifocal early gastric cancers.

The clinicopathologic features of patients with 47 synchronous multifocal early gastric cancers were reviewed retrospectively from hospital records between 1969 and 1994. These patients were then compared to 587 patients with solitary early gastric cancers. Accessory lesions were missed preoperatively in 15 of the 47 patients with multifocal early gastric cancers. Multifocal early gastric cancer was significantly more common in slightly older patients (multifocal versus single: 65.19 +/- 10.65 years versus 59.22 +/- 11.7 years (p = 0.004). Elevated lesions and the intestinal type of cancer were found more frequently in multifocal early gastric cancers than in solitary cancers (p < 0.005). The tumor location was higher in multiple early gastric cancers than in solitary cancers (p < 0.05). The postoperative survival did not differ between the two groups. We conclude that when planning the surgical treatment of early gastric cancers in the elderly, the whole stomach should be evaluated before and during the operation, and after the resected stomach examined.

Age Distribution↗
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Comparison in survival between hepatic metastases of gastric and colorectal cancers.

BACKGROUND/AIM: The outcome after hepatectomy and non-surgical treatment of liver metastases from gastric and colorectal malignancies are reported. METHODOLOGY: Between April 1988 and March 1994, 176 patients with metastatic liver cancer were treated at the First Department of Surgery, Kyoto Prefectural University of Medicine Hospital. RESULTS: All patients received multi-disciplinary treatment, and 51 underwent hepatectomy. The survival after hepatectomy for metastatic liver cancer from a colorectal primary was better than that for gastric cancer. The survival after hepatic arterial infusion (HAI) therapy for metastases from gastric cancer was better than that for colorectal cancer. CONCLUSION: Surgical resection may be the best treatment for liver metastases from colorectal cancer. HAI may be a better option for liver metastases from gastric cancer.

Adult↗
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Analysis of 210 elective hepatic resections.

BACKGROUND/AIMS: Based on our personal cases, the mortality and morbidity of hepatectomy were analyzed. METHODOLOGY: Between April 1988 and October 1995, 210 elective hepatectomies were perf. RESULTS: There were no intraoperative deaths, 5 perioperative deaths and 4 in-hospital deaths. Major complications occurred in 47 patients (22.4%). Minor complications included 44 mild pleural effusions not requiring treatment, 29 wound dehiscences, and 1 case of hoarseness. Multiple regression analysis showed that wound dehiscence and pleural effusions were associated with prothrombin time (t = -2.41, p = 0.017) and incision type (t = 5.57, p < 0.001), respectively. Ascites were associated with operative time (t = 2.25, p = 0.026), blood transfusion (t = 2.23, p = 0.027), prothrombin time (t = 2.16, p = 0.032), and serum total bilirubin (t = -2.026, p = 0.044). Postoperative bleeding was associated with blood loss (t = 3.92, p = 0.0001), blood transfusion (t = -2.73, p = 0.007), and additional surgery (t = 2.15, p = 0.033). CONCLUSION: The mortality of elective hepatic resection can be decreased by adherence to strict surgical indications and meticulous surgical technique. The use of autologous blood transfusion may reduce perioperative complications and morbidity.

Aged↗
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Lymph node metastasis in gastric cancer in the upper third of the stomach--surgical treatment on the basis of the anatomical distribution of positive node.

BACKGROUND/AIMS: Little is known about the most appropriate surgical procedure for gastric cancer in the upper third of the stomach. The objective of this study was to determine the most appropriate surgical treatment for gastric cancer in the upper third of the stomach. METHODOLOGY: The clinicopathological characteristics of 115 node-positive gastric cancers in the upper third of the stomach were reviewed retrospectively and compared with those of 111 node-negative gastric cancers in the upper third of the stomach. RESULTS: Node-positive gastric cancers showed higher rates of peritoneal metastasis (p < 0.005), larger tumor sizes (p < 0.005), deeper tumor penetration (p < 0.005), higher rates of diffuse type in histology (p < 0.025), and more advanced histological stages (p < 0.005), than node-negative gastric cancers. Patients with node-positive gastric cancer demonstrated a poorer survival rate than those with node-negative gastric cancer (p < 0.005). Lymph node metastasis along the lower stomach was observed in cases of gastric cancer which had invaded beyond the muscularis propria of the stomach but not in those confined within the muscularis propria. No lymph node metastasis in the splenic hilum was found in association with gastric cancer when the depth was limited to the mucosa or the submucosa. CONCLUSION: The appropriate surgical procedures for the treatment of gastric cancer in the upper third of the stomach are as follows: a) proximal gastrectomy without splenectomy for gastric cancer when the depth is limited to the mucosa or the submucosa, b) proximal gastrectomy with splenectomy for gastric cancer when the depth of invasion extends to the muscularis propria, c) total gastrectomy with splenectomy for gastric cancer when the depth of invasion extends beyond the muscularis propria.

Female↗
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Protecting the viability of hepatic allografts procured from non-heart-beating donors by blockade of endothelin and platelet activating factor in porcine liver transplantation.

PROBLEM: The function of hepatic allograft from non-heartbeating donors (NHBD) is significantly affected by warm ischemic injury before harvesting. MATERIALS AND METHODS: The effects of the endothelin (ET) antagonist TAK-044 and the platelet activating factor (PAF) antagonist E5880 on the function of grafts from NHBD were evaluated in a porcine orthotopic liver transplantation. The liver grafts were subjected to 90 min of warm ischemia and 4 hours cold preservation. Group 1 (n = 4; n is the number of donor/recipient pairs) was used as a control (untreated). In group 2 (n = 4), donors and recipients were treated with TAK-044 (3 mg/kg). In group 3 (n = 4), pigs were treated with E5880 (0.3 mg/kg). In group 4 (n = 4), pigs were treated with TAK-044 and E5880. RESULTS: The 7 day survival rate of the recipients in groups 1, 2, 3 and 4 was 0, 25, 25 and 100%, respectively (p<0.05, group 1 versus 4). The increases of the serum concentrations of aspartate transaminase, lactate dehydrogenase and arterial lactate 1-4 hours after transplantation were significantly inhibited in the treated groups. CONCLUSION: The blockade of ET and PAF has protective effects on the function of hepatic grafts from NHBD.

Animals↗