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Biomedical subjects

H Tanabe

Publications and source records attributed to H Tanabe.

At least 343 records · Page 19Linked to original sources
PubMed1988

Clinical application of autologous cultured epithelia for the treatment of burn wounds and burn scars.

This report presents our experience with autologous cultured human epithelia grafting on burn wounds, burn scars, and skin-graft donor sites in seven patients. Dispersed epidermal cells were cultured with 3T3 cells treated with mitomycin C. After 2 to 3 weeks, cultured epithelia (total 350 to 2250 cm2) were grafted to the wound. The results showed that cultured epithelia grafts did not take so completely compared to the meshed skin grafts used for the coverage of burn wounds. However, cultured grafts placed on aseptic wounds adhered well and showed good appearance. In the histologic findings, normal differentiation of epidermal cells was found. Cultured grafts were bordered from subepidermal granulative tissue with basement membrane. A rete ridge and the adnexal structures were absent in the specimens that adhered to the burn wounds. However, in the specimens that took on abraded wounds, a gently sloping rete ridge and elastic fibers were seen. The histologic findings showed structures resembling normal skin.

Adult↗
PubMed1987

Skeletal fixation versus skeletal relapse.

The use of skeletal fixation was evaluated for skeletal stability during the period of intermaxillary fixation following a modified sagittal split ramus osteotomy for mandibular prognathism. A combination of bilateral maxillary peralveolar wires and circummandibular wires in the canine region was used for the fixation. One group of patients with this method of fixation (S group) and a second group without the fixation (C group) were compared cephalometrically. Statistically significant differences existed in the amount and pattern of relapse; the fixation produced a significant effect on retention of the corrected chin position. As a consequence, downward and backward rotation of the distal fragment of the mandible and compensatory incisor extrusion were notably controlled. However, upward shift of the posterior end of the distal fragment occurred persistently even in the S group, causing considerable intrusion of the posterior teeth in comparison with the C group. This seems to indicate that tension, probably exerted by the pterygomasseteric sling, is important in postoperative skeletal instability.

Adolescent↗
PubMed1987

Kinetic and stereochemical studies on reaction mechanism of mouse liver 17 beta-hydroxysteroid dehydrogenases.

The kinetic mechanism of two major monomeric 17 beta-hydroxysteroid dehydrogenases from mouse liver cytosol was studied at pH 7 in both directions with NADP(H) and three steroid substrates: testosterone, 5 beta-androstane-3 alpha, 17 17 beta-diol, and estradiol-17 beta. In each case the reaction mechanism of the two enzymes was sequential, and inhibition patterns by-products and dead-end inhibitors were consisted with an ordered bi bi mechanism with the coenzyme binding to the free enzyme, although there was difference in affinity and maximum velocity for the steroidal substrates between the two enzymes. Binding studies of the coenzyme and substrate indicate the binding of coenzyme to the free enzyme, in which 1 mol of NADPH binds to 1 mol of each monomeric enzyme. The 4-pro-R-hydrogen atom of NADPH was transferred to the alpha-face of the steroid molecule by the two enzymes.

17-Hydroxysteroid Dehydrogenases↗
PubMed1987

Conduction aphasia and arcuate fasciculus.

Three patients are presented who developed conduction aphasia after a small infarction almost exclusively confined to the arcuate fasciculus. All of them were diagnosed as conduction aphasia within a week after the stroke and showed a rapid amelioration. On the basis of the 3 patients and conduction aphasics in the literature, the relation between conduction aphasia and the arcuate fasciculus is discussed.

Aged↗
PubMed1987

Effect of 3-[p-(trans-4-aminomethylcyclohexylcarbonyl)phenyl] propionic acid hydrochloride on gastric mucosa directly from the lumen.

The present experiments were designed to determine if the novel anti-ulcer drug 3-[p-(trans-4-aminomethylcyclohexylcarbonyl)phenyl]propionic acid hydrochloride (TEI-5103, TG-51), acts on the gastric mucosa directly from the lumen when given orally. TEI-5103 given orally (50-400 mg/kg) prevented the lesion formation induced by 0.1N HCl + 60% ethanol, but when given intraperitoneally (50-200 mg/kg) or intravenously (40 mg/kg), it did not prevent the formation of lesions. Indomethacin-induced gastric lesions were inhibited by oral administration of TEI-5103, but not by intraduodenal administration. In pylorus-ligated rats, TEI-5103 given intragastrically also inhibited the development of gastric lesions induced by HCl + ethanol. These results suggest that the presence of TEI-5103 in the stomach is necessary to elicit its anti-ulcer effect. In microautoradiographic examination, silver grains corresponding to [14C]-TEI-5103 distributed in the upper part of the mucosa (luminal side) at 0.5 to 4 h after the oral administration. However, when given intraduodenally or intravenously, this high concentration of [14C]-TEI-5103 was not observed in the stomach tissue. When given orally, the content of [14C]-TEI-5103 in rat stomach tissue was about 100 times higher than that in plasma and the time course of distribution was different from that seen in the gastric content. From these results, it seems that TEI-5103 distributes in the gastric mucosa directly from the lumen. In conclusion, TEI-5103, when given orally, distributes in the gastric mucosa as a target issue directly from the lumen; and only the oral and gastric route of administration lead to the anti-ulcer effect.

Administration, Oral↗
PubMed1986

Spectral characteristics of early receptor potential in congenital red-green color blindness.

The spectral response curve (amplitude versus wavelength) of the R2 of the early receptor potential (ERP) was studied in normal, protan, and deutan subjects. The R2 amplitude peaked at 520 nm in most normal subjects. The R2 at long wavelengths was smaller than normal in protans and larger than normal in deutans when the maximum amplitudes were normalized to 100% at the peak. The ratio of the R2 amplitude at 460 nm to that at 600 nm clearly differed between protans and deutans. The ERP and the rapid off-response, which is mainly due to the cessation of the late receptor potential, were recorded in the same subjects. The ratio of the sensitivity of the rapid off-response at 500 nm to that at 600 nm was correlated with the ratio of the R2 amplitude at 460 nm to that at 600 nm (correlation coefficient, 0.823, p less than 0.001). This study, in conjunction with our previous study, indicates that the abnormality is in the outer segments of the cones in protans and deutans.

Adolescent↗
PubMed1986

Auditory extinction to nonverbal and verbal stimuli.

The so-called auditory extinction phenomenon in a verbal dichotic listening test was investigated in seven brain damaged patients from the qualitative standpoint. As the result, it became evident that the phenomenon could result from competition between verbal materials presented to both ears in at least two different levels of auditory processing i.e., sound perception and linguistic recognition. From the present study, we emphasize the following: If Bender's definition is followed, it is advisable to use the term extinction only for the phenomenon at the acoustic level. If the use of the term extinction for the phenomenon is to be continued at the linguistic level, the presence of auditory extinction and/or obscuration to nonverbal stimuli should be noted.

Acoustic Stimulation↗
PubMed1986

Lateralization phenomenon of complex auditory hallucinations.

A case is described of a patient who developed a transient verbal hallucination, lateralized to the right ear, and fluent aphasia after a hemorrhagic infarction in the left superior temporal gyrus. On the basis of this patient and the cases in the literature showing unilateral complex auditory hallucinations, the clinical significance of the lateralization phenomenon of complex auditory hallucinations was investigated. As a result, the lateralization phenomenon of complex auditory hallucinations could be considered a significant clinical sign indicating the existence of a lesion in the superior temporal gyrus opposite the hallucination side.

Aphasia↗