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Biomedical subjects

H Takimoto

Publications and source records attributed to H Takimoto.

104 records · Page 6Linked to original sources
PubMed1983

[Antihypertensive mechanism of oral angiotensin I converting enzyme inhibitor (captopril) in renin-independent essential hypertension].

In order to investigate the possible role of bradykinin in the hypotensive mechanism of angiotensin I converting enzyme inhibitor (Captopril) in renin-independent essential hypertension (EHT), we studied the effects of the single administration of 100 mg captopril on plasma bradykinin levels by sensitive radioimmunoassay in 21 EHT, who showed agonistic responses to 1Sar, 8Ile-angiotensin II (A IIA). Fourteen of the patients were low renin and 7 were normal renin EHT. There was no correlation between the baseline plasma renin activity (PRA) and the fall in mean blood pressure (MBP) following captopril administration. When the patients were analyzed according to MBP response, the responders (R) showed a significantly greater bradykinin increment (delta BK, +64%) (p less than 0.05), whereas the nonresponders (NR) did not show such an increase. There was a positive correlation between delta BK and the MBP reduction after captopril in the R group (r = 0.623, p less than 0.05). Plasma aldosterone (PA) decreased profoundly in the R group (-36% from baseline, p less than 0.05). Pretreatment ACE activity was significantly higher in the R group than in the NR group (p less than 0.05). Pressor response to A IIA showed a significantly (p less than 0.05) greater response after captopril administration in the R group. There were no significant differences in blood concentration of captopril between the R and NR groups. The present results suggest that bradykinin may be involved in the hypotensive action of captopril in the EHT subgroup, where the renin-angiotensin system appears to play an inert role for the elevation of blood pressure.

Adult↗
PubMed1983

Effect of sodium intake on prostacyclin generation in rabbit mesenteric artery.

Effect of sodium intake on prostacyclin (PGI2) generation in response to angiotensin II (A II) or noradrenaline (NA) stimulation was studied using the rabbit mesenteric artery (RMA) perfusion system. 6-oxo-PGF1 alpha, a stable metabolite of PGI2, was continuously released into the effluent at a rate of 10.7 +/- 2.2 ng/min for the initial 60 min. Perfusion pressure and 6-oxo-PGF1 alpha promptly increased in response to A II and NA. Chronic sodium loading caused a significantly (p less than 0.05) smaller PGI2 production following the A II stimulation. Vasoconstrictive responses induced by these stimuli were greater in the high sodium group. Acute changes in potassium concentration at a range between 1.2 and 5.4 mEq/L failed to affect basal PGI2 production, but an augmented response of PGI2 release by A II and NA was observed at the lowest potassium concentration. These results may suggest that vascular prostaglandins may participate in the mechanism of an altered vascular responsiveness during an altered sodium or potassium homeostasis.

6-Ketoprostaglandin F1 alpha↗
PubMed1981

Plasma aldosterone response to angiotensin II in sodium-restricted elderly subjects with essential hypertension.

The plasma aldosterone (PA) response to sodium restriction (25 mEq daily for 4 days) and to graded infusions of angiotensin II (AII, 2, 4 and 8 ng/kg/min each for 30 min) during a low-sodium intake were studied in 15 elderly subjects with mild essential hypertension versus 10 elderly normotensive subjects. The PA response to sodium restriction relative to changes in plasma renin activity (PRA) was estimated by the ratio of PA increment to PRA increment after sodium restriction (delta PA/delta PRA). THe PA response to graded AII infusions was determined by the increment of PA above the basal level after each dose of AII. In 10 of the 15 elderly hypertensive subjects whose PRAs responded normally to sodium restriction, the delta PA/delta PRA ratios and PA increments during the graded AII infusions were similar to those in the elderly normotensive subjects. However, in the remaining 5 elderly hypertensive subjects whose PRAs responded subnormally to sodium restriction, the delta PA/delta PRA ratios were high and the PA increments greater during the graded AII infusions. THe increments of mean blood pressure during the graded AII infusions were similar in the foregoing 10 of 15 hypertensive subjects, and significantly greater during the AII infusion rates of 4 and 8 ng/kg/min in the remaining 5 hypertensive subjects when compared with those in the normotensive subjects. Apparently some subjects with essential hypertension, whose PRAs response subnormally to sodium restriction, have an abnormally enhanced adrenal responsiveness to AII under the conditions of low-sodium intake.

Aged↗
PubMed1979

Results of intraocular lens insertion for traumatic eyes and effects on binocular vision.

Eighteen traumatic eyes were inserted with Medallion lenses in a very complex operation procedure. Eight patients were examined for binocular vision and compared with eight nonpseudophakic eyes. With the exception of tropic eyes, they regained binocular vision. We obtained very hopeful results for the management of seriously traumatic eyes through this study.

Adolescent↗
PubMed1979

A clinical study of tuberculous colitis.

During the last 8 years, the diagnosis of tuberculous colitis has been made radiologically in 22 cases. Twelve were confirmed by histological or bacteriological evidences. The X-ray findings are classified into three types as follows: Type A, showing an extensive scarred area in the ileocecum and ascending colon. Type B, showing annular stricture in the ascending colon and dilatation of its oral side. Type C, showing pouchformation (pseudo-diverticulum) and deformity in the cecum. We emphasize that histological examination and culture of the biopsy specimens by endoscopy were useful for the diagnosis of tuberculous colitis. Furthermore, radiologic changes of the colon by administration of antituberculous drugs were observed.

Adult↗