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Biomedical subjects

H Takeshima

Publications and source records attributed to H Takeshima.

At least 217 records · Page 12Linked to original sources
PubMed1985

Structural analysis of the gene coding for hepatitis B virus surface antigen and its product.

The entire genome of hepatitis B virus (subtype adr) has been cloned into pBR322. The clones could be classified into at least seven groups by their restriction endonuclease cleavage maps. The nucleotide sequences of the hepatitis B surface antigen (HBsAg)-coding regions for five clones were determined and compared with published sequences of the HBsAg gene including those of adw, ayw, adyw and adr. The 13 available versions of the amino acid sequence of the polypeptide, predicted from the nucleotide sequences, were analysed in terms of the established specificities of the HBsAg, including the four subtypes. The analysis indicated that a relatively hydrophilic region of the HBsAg protein, spanning amino acid residues 110 to 160, specifies the major (w) and (r) subtype system. The (w/r) subtype appears to depend on changes in one or more variable amino acids at positions 47, 110, 113, 126 and 160 of the HBsAg polypeptide.

Amino Acid Sequence↗
PubMed1985

Acetyl CoA carboxylase inhibitors from the fungus Gongronella butleri.

Four active metabolites that specifically inhibit acetyl CoA carboxylase, the late-limiting enzyme in fatty acid biosynthesis, have been isolated from a strain of Gongronella butleri mating type (+). Their chemical structures were determined to be octyl pentanedioic acid, 9-decenyl-1-pentenedioic acid, decanyl-1-pentenedioic acid, decanyl-2-pentenedioic acid, respectively. These compounds inhibited rat liver acetyl CoA carboxylase 50% at a concentration of 30 approximately 55 micrograms/ml.

Acetyl-CoA Carboxylase↗
PubMed1985

[Staging pelvic lymphadenectomy for carcinoma of the prostate].

Prospective pathological staging by pelvic lymphadenectomy in 12 patients with clinically localized carcinoma of the prostate disclosed a high incidence (58%) of clinically silent and unsuspected lymph node metastases. The incidence of positive nodes was 0% in patients with clinical stage A disease, 33% in stage B, 100% in stage C disease. Serum acid phosphatase was not a useful staging marker. Excellent correlation existed between histological grade and pathological stage. Gleason's sum was predictive of nodal metastases.

Aged↗
PubMed1985

Survival of patients with tumors of the renal pelvis and ureter: a retrospective study.

A review of 27 patients with renal pelvic tumors and ureteral tumors admitted to the Tsukuba University Hospital was performed retrospectively. Nineteen cases of renal pelvic tumors and eleven cases of ureteral tumors were submitted to the study. These patients were treated mainly by surgery. The rates for 1-year, 3-year, 5-year and 10-year survival were 88.5%, 57.6%, 40.3% and 20.2%, respectively. No obvious relationship between prognosis of renal pelvic tumor and that of ureteral tumors was seen. Pathologically, there was a correlation between the grade and the stage of the tumor. Prognosis was related to the stage of the tumor, but not to the grade of the tumor. Clinically, the patients with positive urinary cytology had a poorer prognosis. It was considered that no relationship existed between the preoperative clinical stage and the postoperative pathological stage. Consequently, the former is not considered a prognostic factor. We have been performing mainly radical nephroureterectomy with regional lymphadenectomy since 1975. The patients who received the operation with regional lymphadenectomy since 1975. The patients who received the operation with regional lymphadenectomy or with adjuvant chemotherapy had a better prognosis. It is concluded that lymphadenectomy is a valuable operation for improving prognosis.

Adult↗
PubMed1984

A case report of Crohn's disease with sigmoido-vesical fistula.

Urological complications in Crohn's disease are relatively common conditions. However, a few cases with sigmoido-vesical fistula as a complication of the disease have been reported. We experienced a case of a 16-year-old boy with pneumaturia due to sigmoido-vesical fistula as a complication of Crohn's disease.

Adolescent↗
PubMed1984

An evaluation of blood serotonin in infertile male patients.

This study was made to clarify what role serotonin plays in testicular function. Forty-five infertile men were subjected to the study; 30 had oligozoospermia and the others had azoospermia. Blood serotonin levels of the patients were determined and the relationship between blood serotonin levels and other clinical findings was evaluated statistically. The mean value of blood serotonin in oligozoospermia was 80.1 +/- 33.0 ng/dl and that of azoospermia was 107.0 +/- 41.2 ng/dl, the difference being significant statistically (p less than 0.05). The blood serotonin level of the patients who had varicocele was 83.4 ng/dl and that of those who did not 94.0 ng/dl, there being no statistically significant difference between them. The level in the patients who had obstructive lesions was 80.3 and that in those who did not 92.1 ng/dl, there being no significant difference between them. The blood serotonin level proved to be unrelated with other clinical findings.

Humans↗
PubMed1983

[A case of amyloidosis of the ureter].

This is a case report of a localized amyloidosis of the ureter presented with gross hematuria. Amyloidosis of the ureter is a rare entity and 21 cases have been collected from the Japanese and English literature. It is believed to be difficult to diagnose before surgery and almost all the cases were treated by nephrectomy. After malignancy was denied, autotransplantation combined with psoas hitch procedure was carried out in order to preserve the kidney. This is the second case of ureter amyloidosis treated by autotransplantation. Amyloidosis was confirmed with Congo red stain and electronmicroscopy of which characteristics is discussed in detail.

Amyloidosis↗
PubMed1983

Renal cell carcinoma in a solitary kidney treated by partial nephrectomy--case report and review of Japanese literature.

Renal cell carcinoma in a solitary kidney is rather rare. We present a case of this condition occurring in a 50-year-old man. He was treated by partial nephrectomy and temporary hemodialysis for postoperative acute renal failure. Perusal of the literature reveals that in situ partial nephrectomy, if possible, seems to be a reasonable treatment of choice for renal cell carcinoma in a solitary kidney. This is the fifth case ever reported in Japan.

Acute Kidney Injury↗
PubMed1983

[Clinical study of urinary cytology: with special reference to bladder cancer].

During the last 66 months, 482 urinary cytologic examinations were performed on 160 inpatients suspected of having genitourinary cancer at our University Hospital. Cytologic diagnosis was done according to the Papanicolaou's classification. The cytologic findings were compared by size, shape, numbers of the tumor and the histologic findings. The positive rate (classes IV and V) was 56.7% (90 patients) in bladder cancer, 22.2% (18 patients) in prostatic cancer, 13.3% (15 patients) in renal cancer and 62.5% (8 patients) in renal pelvic or ureteral cancer. There was no false positive case for benign disease. The positive rate of cytologic examinations for stage A bladder cancer was statistically lower than that for stage B, C and D cancers. There were no statistically significant differences among the stage B, C and D groups. The positive rate in the low grade (grade I and II) bladder cancer was statistically lower than that of high grade (grade III and IV) cancer. In the small tumor less than thumbtip -sized, cytological diagnosis was positive in 40.0%, while in the large tumor larger than this size, the positive rate was 73.3%. The difference between these two groups was statistically significant. The positive rate in the non-recurrent cases of the bladder cancer was 64.5%, while that in the recurrent cancer cases was 39.3%. The difference between these two groups was statistically significant. The positive rate of urinary cytology did not correspond to the shape or number of tumors. It is desirable to perform cytology more than 3 times on the same patient.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1983

[Postoperative complications and followup in cystectomy].

Clinical studies on postoperative complications and prognosis were done on 27 patients who had undergone cystectomy at our hospital. Thirty one postoperative complications were seen in 16 patients. Early complications which developed within 3 months of operation were more frequent (25 cases). They included pyelonephritis (5 cases), wound infection (4 cases), pulmonary complications (2 cases), cardiovascular complications (2 cases), ileus (2 cases) and delayed ambulance (2 cases) in decreasing order of frequency. Complications related to urinary diversion were observed in 4 out of 6 late complications. Reoperation secondary to surgical complications were done in 6 cases. Four of the 6 reoperations were related to gastrointestinal complications, all of which would be fatal if left untreated. Postoperative followup period ranged from 3 weeks to 49 months with a mean period of 12.8 months. The present status of the patients is as follows: 16 patients alive, 10 patients dead and 1 patient lost to followup. So far we cannot draw a definite conclusion regarding the relationship between surgery and the prognosis of the patients because the followup period is too short in many patients. In our experience: 1) The fewest cancer deaths occurred in patients who had undergone radical surgery; 2) the largest percentage of living patients was seen in the group of patients who had undergone radical cystectomy; and, 3) almost all patients with low stage tumors are living more than 6 months after operation.

Adult↗
PubMed1982

Renal autotransplantation for localized amyloidosis of the ureter.

Localized amyloidosis of the ureter is a relatively rare disease, causing at times ureteral stenosis with hydronephrosis and renal function impairment to various extent. Although it is not malignant nearly all reported cases have been treated by nephroureterectomy because it is clinically difficult to differentiate this entity from ureteral malignancy. We report a case in which the ipsilateral kidney was salvaged successfully by renal autotransplantation. To the best of our knowledge, this is the first case reported of renal autotransplantation for localized amyloidosis of the ureter in the English literature. We suggest that renal autotransplantation be considered in cases of localized ureteral amyloidosis.

Amyloidosis↗