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Biomedical subjects

H Takao

Publications and source records attributed to H Takao.

63 records · Page 4Linked to original sources
PubMed1977

Serum creatine kinase isoenzymes in Duchenne muscular dystrophy.

Creatine kinase isoenzymes in sera of 51 patients with Duchenne muscular dystrophy were separated on a micro-column of DEAE Sephadex A-50. MB isoenzyme was detected in the sera of 32 cases (63%). MB percentage of total creatine kinase activity correlated significantly with urinary creatine/creatinine ratio in the early stages of the disease. No close relationship between MB levels and ECG findings was observed. The origin of serum MB in Duchenne dystrophy is discussed.

Adolescent↗
PubMedDate not supplied

Detection of lymph-node metastases in patients with gastric carcinoma: comparison of three MR imaging pulse sequences.

BACKGROUND: To compare the diagnostic accuracy of magnetic resonance (MR) images obtained with three different pulse sequences for lymph-node metastases in patients with gastric cancer. METHODS: T1-weighted spin-echo (SE), breath-hold T2-weighted fast SE, and triphasic gadolinium-enhanced dynamic gradient-recall-echo (GRE) MR images obtained in 16 patients with gastric carcinoma were retrospectively reviewed. Regional lymph nodes were assigned to four different groups, and image review was conducted on a lymph-node group-by-group basis; 64 lymph-node groups were reviewed by two radiologists. Relative sensitivity, specificity, and accuracy were determined based on the findings with definitive surgery and follow-up imaging. Diagnostic accuracy was determined by means of receiver-operating-characteristic (ROC) analysis. RESULTS: Relative sensitivities for lymph-node metastases with T1-weighted SE, breath-hold T2-weighted fast SE, and dynamic GRE images were 61%, 94%, and 59%, respectively. Relative sensitivity with breath-hold T2-weighted fast SE images was significantly greater than that with T1-weighted SE (p < 0.05) and dynamic GRE (p < 0.05) images. Diagnostic accuracy determined by ROC analysis was marginally higher with breath-hold T2-weighted fast SE (area under ROC curve [Az] = 0.87) than with T1-weighted SE (Az = 0.78, p = 0.08) and dynamic GRE (Az = 0.79, p = 0.12) images. CONCLUSION: Breath-hold T2-weighted fast SE sequence is useful in the detection of regional lymph-node metastases in patients with gastric carcinoma.

Abdomen↗
PubMedDate not supplied

Evaluation of angiographically assisted spiral CT in surgical cases of hepatocellular carcinoma considering recurrent cases.

Between June 1993 and July 1996, computed tomography during arterial portgraphy (CTAP) was performed on 22 patients with hepatocellular carcinoma (HCC) and liver cirrhosis before surgery. In 17 out of 22 patients, CT hepatic arteriography (CTA) was combined with CTAP. All 22 patients underwent definitive surgery. In 16 patients in which CTA was successfully performed, 20 HCC nodules and 28 pseudolesions were detected. The pseudolesions were depicted larger in size with CTA than with CTAP, formed a variety of shapes, and were enhanced homogeneously, while HCC nodules were depicted larger with CTAP than with CTA, formed a round or wedge shape, and were sometimes enhanced heterogeneously. Recurrence was diagnosed in 9 of 22 patients. Five recurrent lesions in 4 patients were already revealed by pre-operative CTAP. CTA was performed in only 1 of 5 lesions. The diagnostic accuracy for HCC significantly improves by recognizing by recognizing pseudolesions with CTA and CTAP.

Aged↗