[Radiologic diagnosis of malignant lymphoma of the large bowel (author's transl)].
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Adult↗
Biomedical subjects
H Tajiri
Publications and source records attributed to H Tajiri.
[Minute lesions of the stomach and duodenum in Crohn's disease].
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Adolescent↗
[Clinical significance of multiple cancers including pancreatic cancer--report on 12 cases].
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Adult↗
[A study on cancers in the gastric remnant -from standpoint of radiology (author's transl)].
A radiologic study was done retrospectively of 51 cases with carcinoma of the gastric remnant. In each case, the gastric remnant was resected in Cancer Institute Hospital from January 1952 to December 1978, 1) Descriptive breakdown of the cases: a. 8 cases had benign lesions at the initial gastrectomy. b. 13 cases were found to have recurrent of cancer in the stump or metastasis. c. 16 cases had multiple cancerous lesions. d. 2 cases showed cancer in the reconstructed stomach after excision of esophageal carcinomas. 3. 12 cases had uncertain background information. 2) Chief complaints: Four out of the six cases of early cancer were asymptomatic. In the advanced carcinomas, 22 cases (60%) complained of dysphagia. 3) Period of time until re-resection and periodic examination: The period of time from the initial gastric resection until re-resection was less than 5 years in 22 cases (45%) and greater than 5 years in 29 cases (57%). Thus, periodic examinations employing both x-ray and endoscopy are very important even after 5 years have elapsed since gastrectomy. 4) Radiologic examination of gastric remnant carcinomas: After gastrectomy, particularly in the early period, careful attention should be paid to hyperplastic or granulomatous changes located at the suture line of the lesser curvature and the anastomosis. The sites of remnant carcinomas were found most frequently along the sutured portion of the lesser curvature or the anterior and posterior parts of the gastric remnant in 11 cases (27.5%). Seven cases (17.5%) were found in the cardia and five cases (12.5%) in the anastomosed portion. Therefore, it is very important to perform double contrast radiographs from the left anterior oblique projection which is close to the right lie projection, and to take pictures of the sites from the lower esophagus to the cardia of the stomach.
Adenocarcinoma↗
[Radiographic and pathohistologic studies of 6 patients with early cancer of the gastric remnant (author's transl)].
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Female↗
[A comparative study between radiologic and macroscopic findings of small cancers less than 1 cm in the antrum of the stomach (author's transl)].
A comparative study was made of macroscopic and radiologic findings about 95 lesions (83 cases) of small cancers (10 mm and below) in the antrum of the stomach, and the following results were obtained. 1) Preoperative diagnostic rate was 11/66 (17%) for lesions of micro-gastric cancers (5 mm and below), and 21/29 (72%) for lesions of small gastric cancers 5.1-10). Lesions of microgastric cancers which were preoperatively diagnosed as such were those with size of 3 to 5 mm accompanied by marginal elevations. 2) Radiologic findings about micro-gastric cancers. Some of the micro-gastric cancers which gave some findings in barium filled pictures existing along the greater or lesser curvature were observed as pictures of slight depression. In the compression pictures were noticed niches of irregular linear or stellar shapes with surrounding translucency. For qualitative diagnosis, the compression method was found most effective. It is considered very important to look for small niches, slight translucency, and slight deformity in the greater or lesser curvature carefully.
Adult↗
Clinical application of an ultra-thin pancreatoscope using a sequential video converter.
The main pancreatic duct was studied endoscopically by inserting an ultra-thin pancreatoscope into the normal papilla of Vater. Recently, we developed a new pancreatoscope system and improved the image, the durability, and the ease of use. A special video converter was connected to the head of the pancreatoscope. The sequential electronic endoscope images were observed on a TV monitor. We performed examinations with this new system in 52 cases (8 with pancreatic cancer, 19 with chronic pancreatitis and 25 normal cases). We studied the brightness, color and quality of the images on 35-mm film and on videotape. As a result, it has become clear that the images obtained with this system are much better than those obtained by the conventional method. Although further improvement in the ability to angulate the endoscope is necessary, this new pancreatoscope system should help diagnose diseases of the pancreas.
Chronic Disease↗
Ethanol-related gastric mucosal damage: evidence of a free radical-mediated mechanism and beneficial effect of oral supplementation with bionormalizer, a novel natural antioxidant.
Twenty-two healthy teetotal volunteers underwent gastroscopy during which biopsy samples from the antrum and body were taken for chemiluminescence assay, routine histology, and for malonyldialdehyde, xanthine oxidase and glutathione determination. Subjects were divided into 2 groups which, in a double-blind fashion, were randomly and orally given either (a) Bionormalizer 9 g at bedtime and 3 h prior examination, or (b) flavored sugar 9 g as placebo. During the second gastroscopy 40 ml of 80% ethanol were sprayed perendoscopically. Gastroscopy with biopsy was repeated 60 min later. As compared to the placebo group, subjects given Bionormalizer showed significantly reduced gastric mucosal damage at endoscopy and the histological level. When considering the placebo group, ethanol administration brought about a significant increase in the luminol-amplified chemiluminescence response in gastric mucosa as compared to the baseline value which was correlated with the histological score. The mean chemiluminescence value in the Bionormalizer group was significantly lower than in the placebo group. Ethanol ingestion brought about a significant increase in xanthine oxidase and malonyldialdehyde together with a decreased glutathione concentration. Bionormalizer significantly prevented such changes. The present data suggest that the natural antioxidant Bionormalizer when given orally promotes an effective protection against ethanol-induced gastric mucosal damage.
Administration, Oral↗
Serum levels of vitamin D metabolites in children receiving total parenteral nutrition.
Serum levels of 25-hydroxyvitamin D (25-OHD) and 1,25-dihydroxyvitamin D (1,25-(OH)2D) were measured on 19 occasions in seven children receiving total parenteral nutrition (TPN). The daily intakes of vitamin D3 ranged from 44 to 540 IU/day, and all serum samples were obtained after the same daily intake of vitamin D3 for more than 1 month. There was a significant positive correlation between serum 25-OHD levels and parenteral vitamin D3 intakes (r = 0.90, p less than 0.01). In this study, serum 25-OHD levels in all cases taking 200 to 360 IU/day of vitamin D3 were within the normal range. On the other hand, no significant correlation was found between serum 1,25-(OH)2D levels and vitamin D3 intakes, and serum 1,25-(OH)2D levels were normal or elevated in all cases.
Calcifediol↗
Manganese deposition in the brain during long-term total parenteral nutrition.
BACKGROUND: Manganese deposition was suspected in a pediatric patient who received long-term total parenteral nutrition. T1-weighted magnetic resonance images revealed high intensity areas in the globus pallidus. This study was designed to clarify if these abnormal findings were related to manganese deposition and clinical neurological manifestations. METHODS: Whole-blood manganese concentrations were measured during manganese supplementation to total parenteral nutrition and after 5 months without manganese. Magnetic resonance images were also examined on each occasion and compared with the blood level of manganese. RESULTS: The whole-blood manganese level during supplementation was 135 micrograms/L (normal range 14.6 +/- 4.7 micrograms/L), whereas the level was 20 micrograms/L after a manganese-free period of 5 months. Accompanied with normalization of manganese level, abnormal high intensity lesions in the globus pallidus on T1-weighted images also disappeared. No neurological manifestation related to the high manganese level was recognized. CONCLUSIONS: It is probable that the high manganese level was elicited by manganese supplementation to total parenteral nutrition. This high manganese condition was confirmed by the measurement of whole-blood manganese level, which was associated with the abnormal high intensity lesions on T1-weighted magnetic resonance images.
Brain↗
Detection of bile duct cancer by autofluorescence cholangioscopy: a pilot study.
BACKGROUND/AIMS: There is increasing interest in the detection of malignancy by autofluorescence endoscopy. This is the first report on autofluorescence endoscopy in bile duct cancer. METHODOLOGY: Nine patients with bile duct cancer underwent percutaneous transhepatic autofluorescence cholangioscopy using light-induced fluorescence endoscopy in the gastrointestinal tract (LIFE-GI) system. RESULTS: The cancerous lesion had quite a different color in comparison with normal mucosa, which was seen as light blue, by the autofluorescence endoscopy. In all patients, cancerous legions were observed as dark red. Additionally, in 7 of the 9 cases a white fluorescence was also seen in the cancerous lesion. CONCLUSIONS: In previous reports on the gastrointestinal tract and bronchial tree, cancerous lesions appeared dark red when examined by autofluorescence endoscopy. In our study, it is suggested that a white fluorescence is also an important finding for making diagnosis of bile duct cancer by the autofluorescence endoscopy.
Bile Duct Neoplasms↗
Streptococcus milleri infection and pericardial abscess associated with esophageal carcinoma: report of two cases.
We report 2 cases of esophageal carcinoma with esophago-mediastinal fistula that developed pericardial abscess due to Streptococcus intermedius infection. Streptococcus intermedius, a generally harmless commensals in healthy humans, is not usually associated with infections of the oral cavity but may account for non-oral purulent infections. This report, however, highlights that Streptococcus intermedius infection can be life-threatening for some patients such as those with esophageal carcinoma with fistula.
Abscess↗
Drainage area of the head of the pancreas by computed tomography under endoscopic retrograde pancreatography (ERP-CT).
BACKGROUND/AIMS: This study evaluated the drainage area of the capitular branches of the pancreas head by computed tomography under endoscopic retrograde pancreatography (ERP-CT). METHODOLOGY: ERP-CT was performed in 43 patients. The drainage area of the capitular branches of Wirsung's and Santorini's ducts were evaluated by dividing the pancreatic head into two areas, the anterior area and the posterior area. RESULTS: The pancreatic duct pattern was classified in 4 types; normal type, ansa type, loop type, and embryonic type. In normal type duct pattern, all inferior capitular branches of Wirsung's duct drained the posterior area and all inferior capitular branches of Santorini's duct drained the anterior area. In ansa type duct pattern, all inferior branches from Wirsung's duct drained the posterior area and inferior branches from Santorini's duct drained the anterior area and the posterior area. In loop type duct pattern, all inferior branches from Santorini's duct drained the posterior area and inferior branches from Wirsung's duct drained the anterior area and the posterior area. Middle capitular branches were detected only in normal B, normal C, and loop type. CONCLUSIONS: ERP-CT is a useful procedure that provided three-dimensional morphology of the capitular branch of the pancreas head.
Cholangiopancreatography, Endoscopic Retrograde↗
Photodynamic therapy based on combined use of 5-aminolevulinic acid with a pheophorbide-a derivative for murine tumors.
BACKGROUND: 5-Aminolevulinic acid (5-ALA)-based photodynamic therapy (PDT) appears to be a promising cancer treatment modality. Here, we investigated whether enhancement of 5-ALA-PDT by combining another photosensitizer, a pheophorbide-a derivative (PH-1126), is an option. MATERIALS AND METHODS: PH-1126 (2.5, 5 or 10 mg/kg.bw) and 5-ALA (168 mg/kg.bw) were injected i.p. into C3H/HeN mice bearing squamous cell carcinoma (SCC) or BALB/c nude mice bearing L5178Y lymphoma. Afterwards, these mice received laser irradiations (630 nm for 5-ALA and 650 nm for PH-1126) with a total dose of 88 J/cm2. The results showed that PDT with 5-ALA plus PH-1126 at a low dose (2.5 mg/kg.bw) were well tolerated by both animal models, with resultant synergistically enhanced inhibition of tumor growth and/or survival advantage for the treated animals. CONCLUSION: This study demonstrated the usefulness of the combination of a low dose PH-1126 with 5-ALA for PDT of experimental tumors in vivo.
Aminolevulinic Acid↗
Cyanocobalamin absorption abnormality in alcoholics is improved by oral supplementation with a fermented papaya-derived antioxidant.
BACKGROUND/AIMS: Thirty alcoholic patients and 24 teetotaler dyspeptic patients were considered and underwent baseline blood chemical evaluation and the Schilling test. METHODOLOGY: During gastroscopy, biopsy samples were taken to assay: routine histology, malonyldialdehyde, vitamin E and glutathione concentration and for testing vitamin B12-Intrinsic Factor binding. Examinations were repeated after 1-week supplementation with Bionormalizer. RESULTS: Plasma malonyldialdehyde level and lipid hydroperoxides concentration as well as either malonyldialdehyde and xanthine oxidase concentration in the gastric mucosa in alcoholics were significantly higher than in controls and despite unchanged alcohol consumption, significantly decreased after Bionormalizer supplementation. Gastric mucosal glutathione was markedly depressed in alcoholics and partly recovered after Bionormalizer supplementation. Although the alcoholics showed a normal intrinsic factor secretion in the gastric juice, they exhibited a markedly depressed intrinsic factor-cobalamin binding on the "ex vivo" study. Moreover, nearly 23% of them had an abnormal Schilling test. Both these impairments reverted to normal after Bio-normalizer supplementation. CONCLUSIONS: It can be postulated that the antioxidative action played by Bionormalizer, possibly due to its availability substrates for glutathione synthesis as well as to its effects on local oxidative burst from neutrophil, is able to recover a normal cobalamin absorption.
Administration, Oral↗
Hepatic arterial infusion of 5-fluorouracil for liver metastases from pancreatic carcinoma: results from a pilot study.
BACKGROUND/AIMS: Liver metastasis is a common progression of pancreatic carcinoma, but an effective chemotherapy has not been established. The purpose of this study was to examine the efficacy and safety of a hepatic arterial infusion of 5-FU in patients with liver metastasis from pancreatic carcinoma. METHODOLOGY: Thirteen patients were enrolled in a pilot study of a hepatic arterial infusion of 5-FU therapy. They received 5-FU for 5 days at a dose of 500 mg/m2/day by continuous hepatic arterial infusion every 4 weeks. RESULTS: One patient showed a partial response, while 6 showed no change. Of these 6 patients, 2 showed a minor response. The overall response rate was 8% (95% confidence interval: 0-22%). Nausea and vomiting were the most common types of toxicity. Three patients (23%) had hepatic arterial occlusion. There were no life-threatening toxicities or complications. The overall median survival time was 15.9 weeks. CONCLUSIONS: Hepatic arterial infusion of 5-FU in patients with liver metastasis from pancreatic carcinoma is tolerable but is minimally effective at this dose and schedule. The schedule of administration should be modified.
Adenocarcinoma↗
Improvement of hemorheological abnormalities in alcoholics by an oral antioxidant.
BACKGROUND/AIMS: It has been shown that alcohol impairs erythrocyte (red blood cell) membrane fluidity and lipid composition. The aim of this study was to test the effect of a novel acid-resistant antioxidant on the hemorrheology in alcoholics. METHODOLOGY: Thirty alcoholics (25 males, 5 females; mean age: 42 years; range: 31-54; 150 g ethanol/day for 3-5 years) were enrolled into the study. Patients were randomly and double-blindly allocated into 2 groups which were given, for a 2 week period, 18 g/day of Bionormalizer (obtained from biofermentation of carica papaya, pennisetum purpureum, sechium edule, Osato Res. Foundation, Gifu, Japan) dissolved in 5 mL of water at bedtime and 3 hours prior to examination. Placebo consisted of flavored sugar. Healthy teetotalers served as control. On the examination day, blood samples were taken for testing: routine tests, plasma glutathione, ascorbic acid, selenium, plasma lipid hydroperoxides and alpha-tocopherol. Erythrocytes were separated and tested for red blood cell malonyldialdehyde and glutathione content. The hemorheological studies were as follows: blood and plasma viscosity, whole blood filterability, red blood cell membrane fluidity by electron spin resonance, red blood cell aggregation index by photometric rheoscopy and red blood cell deformability by ektacytometry. RESULTS: As compared to healthy controls, alcoholics on placebo treatment showed no change of plasma viscosity but a significantly higher red blood cell malonyldialdehyde, blood viscosity (P < 0.05) and lower plasma glutathione, whole blood filterability and red blood cell fluidity (P < 0.01). No relationship appeared between biochemical tests and red blood cell membrane fluidity. Bionormalizer group showed a significant recovery to control values of either blood viscosity and whole blood filterability (P < 0.01) and a partial, although significant, improvement of red blood cell membrane fluidity, red blood cell malonyldialdehyde and plasma glutathione (P < 0.05). As compared to healthy control, red blood cell aggregation decreased in alcoholics (P < 0.05) and was not affected by Bionormalizer. However, Bionormalizer significantly improved the reduced red blood cell deformability (P < 0.05 vs. alcoholics) and this parameter correlated with red blood cell malonyldialdehyde (r: 0.62. P < 0.05). CONCLUSIONS: These preliminary data suggest that an effective antioxidant supplementation is able to improve the hemorrheology in alcoholics either by directly affecting the ethanol-related lipoperoxidation and xanthine oxidase system activation and/or by modifying red blood cell membrane characteristics.
Adult↗
Adenovirus-mediated p16 gene transfer changes the sensitivity to taxanes and Vinca alkaloids of human ovarian cancer cells.
BACKGROUND: Deletions and point mutations of the p16 gene are detectable in more than 50% of ovarian cancer cells. In this study, we examined the effect of p16 gene transduction on the growth of ovarian cancer cells and on the effect of anti-cancer agents. MATERIALS AND METHODS: p16-null human ovarian cancer cell lines, SKOV-3 and OVCAR-5, were used in this study. We transduced the full-length human p16 gene using recombinant adenovirus (AxCA-hp16). RESULTS: The spontaneous growth of these cells was significantly inhibited by hp16 transduction. MTT assay revealed that AxCA-hp16 infection induced chemoresistance in both cell lines. Flow cytometric analysis revealed that only hp16 -transduced SKOV-3, were arrested at the G1-phase for 3 days whereas those infected with AxCA-mock and OVCAR-5 infected with both recombinant viruses did not. Western blot analysis showed increased microtubule-associated proteins 4 (MAP4) in both cell lines. CONCLUSION: These results suggest that in SKOV-3 cells, G1-arrest induced by p16-transduction prevents paclitaxel- and vindesine-induced cell death, and in OVCAR-5 cells, the other unknown mechanisms play a role of chemoresistance.
Adenoviridae↗