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Biomedical subjects

H Taguchi

Publications and source records attributed to H Taguchi.

At least 397 records · Page 22Linked to original sources
PubMed1987

"Giant pneumoaneurysm" after combined internal carotid artery occlusion and extracranial-intracranial anastomosis.

A patient with a giant aneurysm of the internal carotid artery (ICA) was treated by combined ICA occlusion in the neck and superficial temporal artery to middle cerebral artery anastomosis. Six months after complete closure of the ICA, the patient had episodes of nasal discharge mixed with dark red, old blood. Computed tomographic scan demonstrated that the lumen of the giant aneurysm was filled with a large amount of air, which communicated with the nasal cavity. Not finding a similar case in the literature, we named this entity "giant pneumoaneurysm." After direct operation, the giant pneumoaneurysm collapsed. This unusual complication may be due to a decrease of blood supply to the aneurysmal wall through the vasa vasorum.

Adult↗
PubMed1987

[Sex-related alterations in the functional development of the thermoregulatory system of rats exposed to tricyclic antidepressants at an early age].

Five mg/kg of imipramine (IMI) or desipramine (DMI) was injected s.c. to Wistar-Imamichi male and female rats daily from 7 approximately 19 days of age. Control pups received saline. The body temperature of IMI-females showed a significant rise at 7, 8 and 12 weeks of age. Thermic responses to thyrotropin-releasing hormone (TRH, 10 mg/kg, i.p.) at 5 weeks of prepubertal age showed no marked changes. At 9 weeks of age, IMI-males showed a significant hyperthermia 15 approximately 30 min after TRH. Control and IMI-males were castrated at 9 weeks of age. At 11 weeks of age, castrated IMI-males showed a significant decrease in the TRH-induced hyperthermia compared to sham-operated or intact IMI-males. These castrated male rats were treated with a single dose of 20 mg/kg of testosterone enanthate (s.c.) at 11 weeks of age. There was no significant difference in the TRH-induced hyperthermia between the groups when tested at 13 weeks of age. Results suggest that the exposure of the infantile rats to imipramine induces sex-related functional alterations in the thermoregulatory system after puberty and that sex hormones may play a modulatory role for these changes.

Aging↗
PubMed1987

Imipramine administered during an infantile period modifies sex difference in L-5-hydroxytryptophan-induced head shakes in rats.

Five mg/kg imipramine or desipramine was injected to infantile rats. L-5-Hydroxytryptophan-induced head shakes were assessed when rats were mature. The saline- and desipramine-treated adult male rats exhibited more sustained response to L-5-HTP than females. The time course of the head shake frequency in the imipramine-treated male and female rats showed a pattern between control males and females, resulting in no significant sex difference. The results suggest that infantile exposure to imipramine induces an alteration of the serotonergic neurons of the brain.

5-Hydroxytryptophan↗
PubMed1987

Relationship between serum thyroxine concentration and dialyzable triiodothyronine fraction in patients with hyper- and hypothyroidism.

The interrelationship between the dialyzable triiodothyronine (T3) fraction (DFT3), T3, and thyroxine (T4) was examined in various groups of patients with hyper- and hypothyroidism. Partial correlational analysis showed that DFT3 correlated significantly with T4 (r = 0.383, N = 114, P less than 0.001), but not with T3 (r = 0.132). DFT3 exceeded the normal range when T4 was supranormal. The relation between T3 and free T3 (FT3) was quadratic (R2 = 0.944, N = 112, P less than 0.001). When the patients were divided into two groups according to T4 levels, the regression line between T3 and FT3 in patients with supranormal T4 was more than twice as steep as that obtained in patients with normal or subnormal T4 levels. In addition, the DFT3 and FT3 values were higher in patients with hyperthyroidism and both elevated T4 and T3 than in patients with hyperthyroidism and only elevated T3. The results indicate that T4 is a major factor influencing the DFT3 value, except when the T4-binding globulin concentrations vary markedly, and that the T4 level should be taken into account for a clinical evaluation of the FT3 concentration in hyper- and hypothyroidism.

Adult↗
PubMed1987

Mother-to-offspring transmission of human T cell leukemia virus type I in rabbits.

We studied the mode of natural transmission of human T-cell leukemia virus type I (HTLV-I) in rabbits. Four virus-infected rabbits (2 males and 2 females) were individually mated with 4 noninfected rabbits. Two virus-infected females mated with noninfected males gave birth to 7 offspring, and 2 noninfected females mated with infected males delivered 5 offspring. Four of the seven offspring born to the virus-infected mothers seroconverted for HTLV-I when aged 6 to 13 weeks with antibody titers of 1:40 to 1:160. None of the five offspring born to the noninfected mothers became seropositive during the observation period of 6 months, however. Peripheral lymphocytes were cultured with T cell growth factor, and HTLV-I-carrying lymphoid cell lines were established from the four seroconverted rabbits. All four cell lines were of T cells positive for Ia antigens. In addition, none of five newborn rabbits killed immediately after birth to a virus-infected rabbit was infected with HTLV-I. These findings provide an experimental support for the milkborne transmission of HTLV-I from mother to child in humans and indicate that the virus is tropic for T cells in rabbits as well.

Animals↗
PubMed1987

Gastric lymphoma associated with human T-cell leukemia virus type I.

A 41-year-old woman presented with a gastric lymphoma. A total gastrectomy was performed, and the tumor was found to consist of T cells of the helper/inducer (E+, Leu-1+, Leu-2a-, Leu-3a+) phenotype. The patient was seropositive for T-cell leukemia virus type I, and the tumor cells contained the proviral genome.

Adult↗
PubMed1987

Wide distribution of rat hepatoma asialo GM1 and its different responses to anti-asialo GM1 antibody-mediated in vitro and in situ cell killing.

By means of TLC immunostaining with anti-asialo GM1 antiserum and conventional structural analyses including exoglycosidase treatment, permethylation and negative ion FABMS, asialo GM1 was found to be widely distributed in rat ascites hepatomas, AH130, AH109A, AH44, AH272, AH41C, AH60C, AH414, AH7974, AH66, AH66 alpha F, AH66F and AH13, and Yoshida sarcoma cells. However, reactivity of asialo GM1, when measured by flow cytometry and complement-mediated cytotoxicity assay with anti-asialo GM1 antiserum, was only observed on AH13 and AH66F, and did not necessarily correspond to the concentration of asialo GM1 on the cells, indicating a cryptic or unreactive nature of glycosphingolipids with respect to their antibodies. On the other hand, although rats injected with 10(7) cells of AH66F died within 7 days, treatment of the rats with anti-asialo GM1 antiserum was found to be effective for their cure or for prolonging their survival, indicating an in situ cytotoxic effect of antiserum. For the in situ cytotoxicity, the timing and period of injection and the dose of antiserum were found to be important.

Animals↗
PubMed1987

Establishment of a new human B cell line carrying t(11;14) chromosome abnormality.

A new human cell line, SP-49, was established from the peripheral blood of a patient with leukemic conversion of diffuse lymphoma, medium-sized cell type. SP-49 cells were shown to have intracytoplasmic and surface immunoglobulin and Leu-12 antigen, but were negative for Epstein-Barr virus nuclear antigen. Chromosome analysis demonstrated that SP-49 had t(11;14) chromosome translocation involving 11q13 and 14q32, where oncogene bcl-1 and immunoglobulin heavy chain gene, respectively, were reportedly located.

B-Lymphocytes↗
PubMed1987

[Clinical studies on the recurrence of urolithiasis: (1). Influence of diet on urinary excretion of the stone forming constituents].

Twenty-four hour urinary excretion of the stone forming constituents, calcium, oxalate, uric acid, phosphate and magnesium were assayed either under the restricted diet (190 stone formers and 52 non-stone formers) or under the ambulatory free diet (93 stone formers and 14 non-stone formers). Under the ambulatory free diet, urinary excretion of calcium, uric acid and magnesium in the male stone formers, and urinary excretion of calcium and magnesium in the female stone formers was significantly higher than that under the restricted diet. Under the restricted diet, no difference in urinary excretion of calcium, oxalate, uric acid or phosphate was noted between the stone formers and non-stone formers. However, urinary magnesium excretion of the stone formers under the restricted diet was significantly lower than that of the non-stone formers. Under the free diet, no difference in urinary excretion of calcium, oxalate, uric acid, phosphate or magnesium was observed between the stone formers and non-stone formers. Also, there was no significant difference in urinary excretion of calcium, oxalate, uric acid, phosphate or magnesium between the unilateral urolithiasis patients without previous stone history and that of the bilateral or recurrent stone formers. We conclude that urinary excretion of calcium, oxalate, uric acid, phosphate and magnesium have no major role in the stone producing mechanism. However, reduction of urinary excretion of calcium, oxalate, uric acid and phosphate and augmentation of urinary excretion of magnesium are mandatory in preventing stone recurrence until a better understanding of the cause of urolithiasis is obtained.

Calcium↗
PubMed1987

[Clinical studies on recurrence of urolithiasis. (2) Hypercalciuria and recurrence of urolithiasis].

According to the dynamics of the urinary calcium excretion mechanism, we have classified the patients with urolithiasis into 4 groups, namely group I (normocalciuria; urinary calcium excretion of 270 mg/day or less for male patients and 210 mg/day or less for female patients), group II (absorptive hypercalciuria; hypercalciuric with urinary calcium excretion of 200 mg/day or less under the low calcium diet), group III (renal hypercalciuria; hypercalciuric with urinary calcium excretion exceeds 200 mg/day even under a low calcium diet), and group IV (hyperparathyroidism; hypercalciuric patients as in group III with high serum calcium). Of the 97 stone formers, 77 were classified into group I, 9 into group II, 8 into group III and 3 into group IV. Both under the restricted diet and under the ambulatory free diet, urinary calcium excretion of groups II, III and IV was significantly higher than that of the group I patients. It was noteworthy, however, that some of the patients in group I excreted much calcium without restriction of their diet. Although no difference in excretion of oxalate, magnesium and phosphate was observed between the 4 groups, the patients in groups II, and III excreted more uric acid into their urine than group I patients. As for stone recurrence rate, no difference was noted between group I and group II, III or IV. Based on these findings, we conclude that hypercalciuria has no significant role in the stone forming mechanism. However, lowering of urinary calcium and other stone forming constituents is mandatory in preventing stone recurrence until the mechanism of stone formation is elucidated more precisely.

Calcium↗