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Biomedical subjects

H Tagami

Publications and source records attributed to H Tagami.

At least 433 records · Page 24Linked to original sources
PubMed1982

The speckled epidermal nuclear immunofluorescence of mixed connective tissue disease seems to develop as an in vitro phenomenon.

The pathogenesis of speckled epidermal nuclear immunofluorescence in patients with mixed connective tissue disease (MCTD) was studied by reproducing this reaction in guinea-pigs, using serum samples containing high titre antibody to ribonucleoprotein (RNP). Immunofluorescence studies on specimens obtained from guinea-pig skin into which serum samples containing high titre RNP antibody had been injected intradermally, revealed positive epidermal nuclear staining for IgG. This speckled immunofluorescence was demonstrable immediately after injection and remained so for 24 or 48 h. The pattern of fluorescence was similar in all cases, and there was no penetration of RNP antibody through the cell membrane. The epidermal nuclear fluorescence was not detected with sera at a dilution of 1:100 or more. These results provide strong evidence that the epidermal nuclear immunofluorescence observed in patients with high titre antibody to RNP develops as an in vitro phenomenon.

Animals↗
PubMed1982

Cartilaginous nevus on the glabella.

Cartilaginous nevus usually occurs in front of the auricle as an accessory auricle and much less frequently on the cheek or anterior part of the neck. We report a case of cartilaginous nevus found on an unusual location, The glabella of the face, in an otherwise normal newborn girl. We think that it was a remnant of the branchial cartilage derived from the first pharyngeal arch of embryonic life.

Facial Neoplasms↗
PubMed1982

Treatment of pustulosis palmaris et plantaris with oral doses of colchicine.

The effect of oral doses of colchicine on pustule formation was studied in 32 patients with pustulosis palmaris et plantaris without associated psoriasis. Oral administration of colchicine, 1 to 2 mg daily, was started during periods of disease exacerbation, and the dosage was gradually decreased to 0.5 to 1 mg daily in responsive patients. Thirteen patients showed complete clearing of pustulation, and 14 patients showed a remarkable reduction in pustule formation after two to eight weeks of treatment. One patient did not respond and four discontinued treatment because of nausea or diarrhea. During a three-month follow-up evaluation after treatment was stopped, relapse occurred in eight cases. Colchicine appears to be effective in the suppression of acute exacerbations of pustulosis palmaris et plantaris.

Administration, Oral↗
PubMed1982

Lymphadenoid structure induced by gold hypersensitivity.

An allergic sensitivity to gold earrings produced a lymphadenoid reaction with germinal centers in the dermis of the pierced earlobes of a 21-year-old woman, However, a patch test for 1% gold sodium thiomalate gave a long-lasting, clinically and histologically eczematous response. Electron microscopic and cytochemical observations showed that non-T lymphocytes and plasma cells were dominant in the dermal infiltrate of the lesions, whereas lymphocytes with convoluted nuclei (which were probably T cells) and monocytes invaded the epidermis in the patch test site. These findings suggest that continuous exposure of the dermis to gold in a sensitized person may induce a lymphadenoid cellular reaction different from the histologic findings seen after contact with the epidermis.

Adult↗
PubMed1982

Complement levels in human tears.

The single radial immunodiffusion technique was modified to determine tear complement component C3 with small sample volume. The C3 levels in the tears from 18 normal subjects and 42 patients with ocular diseases were determined using this method. In the normal subjects, the mean level of tear C3 was 5.12 mg per 100 ml. The physiological level of tear C3 was estimated to be less than 10 mg per 100 ml from the results in normal subjects and patients with noninflammatory ocular diseases. The cases of severe inflammatory diseases such as antiviral keratoconjunctivitis, herpetic keratitis and acute catarrhal conjunctivitis showed a high level of C3 in the tears. The C3 level was relatively low in the cases of mild inflammatory diseases such as allergic conjunctivitis. These results indicated that protein concentration of C3 in the tear was proportional to the severity of inflammation of the anterior ocular segment.

Complement C3↗
PubMed1981

Ultrastructural studies of spontaneously regressing plane warts. Macrophages attack verruca-epidermal cells.

Plane warts were examined at the earliest phase of spontaneous involution using an electron microscopy. Macrophages outnumbered lymphocytes in invading the epidermis. Lymphocytes exhibited pseudopods on the surface which occasionally reached into the epidermal cells. The cell membranes of both macrophages and epidermal cells frequently disappeared on the contacting surface and on occasion part of the cytoplasm and even the nucleus of macrophages invaded the epidermal cells. The macrophages showed an independent partial loss of their cell membranes with a subsequent outpour of their contents. This ultrastructural feature indicates that in spontaneously regressing plane warts the depressed membrane stability of macrophages as observed in BCG and other-induced tumor cell destruction also occurs in the presence of lymphocytes. Therefore, the spontaneous involution may represent a rejection phenomenon.

Adult↗
PubMed1981

Ultrastructural studies of spontaneously regressing plane warts. Langerhans cells show marked activation.

Ultrastructural changes in Langerhans cells during spontaneous involution of plane warts were examined. In areas with activated macrophages and epidermal cell interaction, Langerhans cells showed signs of enhanced cellular activity with an increased number of Langerhans cell granules, as in contact dermatitis. The fine structure of Langerhans cell granules, however, was unusual in that the vesicular portion was surrounded by a membrane, and this portion frequently occurred independently taking the shape of a loop.

Dermatitis, Contact↗
PubMed1981

Multinucleated epidermal giant cells in inflammatory skin diseases.

The occurrence of multinucleated epidermal giant cells (MEGCs) with more than three clumping nuclei has been considered an episodic and exceptional phenomenon in inflammatory skin diseases. However, we have found them in 97 histologic specimens obtained from inflammatory lesions. They appeared in 88 of 196 biopsy specimens from a group of patients with chronic eczema or prurigo. In pruriginous lesions alone, they were found in 67 (74%) of 90 specimens. On the other hand, MEGCs were found rarely in lichen amyloidosus (2/11), dermatitis herpetiformis (1/6), erythema multiforme (1/11), pustular psoriasis (1/17), lichen planus (1/29), lupus erythematosus (1/30), and pustulosis palmaris et plantaris (1/41), probably representing just a chance occurrence in these dermatoses.

Cell Nucleus↗
PubMed1980

The phenomenon of spontaneous regression of numerous flat warts: immunohistological studies.

The phenomenon of systemic regression of numberous flat warts takes place within one month after the sudden onset of spontaneous inflammation in them. In other types of warts, we have never observed such a dramatic regression. We performed a histological study in a total of 51 cases showing this spontaneous inflammation in their flat warts and found a massive mononuclear cell infiltration in all. In 9 cases, a histological study for basophils was carried out but failed to show them among the infiltrating cells despite the strong histological resemblance to contact allergy. An immunofluorescence technique performed in 16 cases demonstrated no specific deposits of immunoglobulins and complement in such inflamed wart tissues except for those which appear to be only a secondary event to inflammation per se. These immunopathological findings further substantiate the concept that cell-mediated mechanisms rather than humoral immunity play a major role in this phenomenon of sudden regression of numerous flat warts.

Adolescent↗