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H T Waaler

Publications and source records attributed to H T Waaler.

62 records · Page 4Linked to original sources

Use of an epidemiological model for estimating the effectiveness of tuberculosis control measures. Sensitivity of the effectiveness of tuberculosis control measures to the social time preference.

Different combinations of coverage levels of BCG vaccination and of case-finding and treatment may achieve the same problem reduction in epidemiological terms. But the same problem reduction, in man-years of tuberculosis, may be valued differently in social terms.A social-time-preference parameter, of the form 1/(1+r)(t), is relevant to this evaluation and the level of r is critical for policy decision. The present paper studies the sensitivity of the effectiveness of BCG vaccination and of case-finding and treatment to the level of r, and the epidemiological mechanism underlying such sensitivity. A high value of r can be visualized as corresponding to a close planning horizon, a lower value of r to a more distant one. At any level of epidemiological effectiveness, a planner with a high value of r would favour case-finding and treatment, and a planner with a low value of r would tend to emphasize BCG vaccination. This influence of the social-time-preference parameter on the planner's decision is found to depend on the discounting effect of the parameter on the one hand, and on the different age- and time-patterns of the preventive effect of the major control measures, on the other.

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The use of an epidemiological model for estimating the effectiveness of tuberculosis control measures. Sensitivity of the effectiveness of tuberculosis control measures to the coverage of the population.

Given an adequate definition of the disease problem in epidemiological terms, it is possible to measure the epidemiological effectiveness of control measures in terms of problem reduction. This is to be distinguished from the clinical efficacy of the same measures. The practical difficulty in assessing the epidemiological effectiveness of control measures experimentally can be overcome by the construction of simulation models and the use of computers, whereby the problem reduction associated with various control strategies can be estimated numerically.By varying the levels of certain parameters of the model systematically, the sensitivity of the effectiveness of control measures to the epidemiological, operational, clinical and social parameters of a situation can be assessed. A series of articles analysing this relationship is under preparation. This first article analyses the sensitivity of the effectiveness of BCG vaccination and of the chemotherapy of tuberculosis to changes in the coverage of the eligible population groups. A previously formulated postulate stating that the marginal effectiveness of these measures decreases as their coverage increases is validated by this first series of simulations. The significance of this finding for planning national tuberculosis control strategies is discussed, as well as possible bias in the method applied.

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