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Biomedical subjects

H T Ford

Publications and source records attributed to H T Ford.

97 records · Page 6Linked to original sources
PubMed1977

Biochemical markers in human breast cancer.

Nineteen biochemical parameters, most of which have been individually advocated as tumour-index-substances for breast cancer, were measured in 51 patients with breast disease, 42 of whom had active breast cancer. Seven of these parameters were raised in more than half of the 17 patients of the series with overt metastases; these were serum ferritin (88%), C-reactive protein (87%), carcinoembryonic antigen (81%), acid glycoprotein (75%), total alkaline phosphatase (64%), sialyl transferase (56%), andthe urinary hydroxyproline/creatinine ratio (73%). The incidence of biochemical abnormalities in patients in this group compared favourably with the results of physical methods of detecting metastases. 7 of 16 further patients without evidence of distant metastases, but who had a poor prognosis as judged by histology of the primary tumour and axillary lymph-nodes, had abnormalities of at least one of the seven parameters. 3 of these patients have relapsed within a year of mastectomy. The results suggest that these biochemical tests could assist in monitoring metastatic disease and could indicate at the time of mastectomy, patients who might benefit from immediate systemic therapy in addition to local treatment of their breast carcinomas.

Adenofibroma↗
PubMed1975

The results of radiotherapy for Hodgkins' disease.

The results of radiation therapy in 212 patients with stages I and II Hodgkin's disease treated between 1963 and 1973 show that approximately 60% remain disease-free following treatment. Multiple node involvement in stage II, particularly associated with infraclavicular node disease, is identified as a group where the relapse rate is high. This presentation is associated particularly with NS. In a group of 78 patients treated with radiotherapy following staging laparotomy and splenectomy approximately 80% remain in complete remission. The preliminary results of treatment in PS IIIa patients are substantially the same as those for PS I and II; the results of treatment for NS and MC disease are similar. The significance of involvement of the spleen is discussed. Although it is probable that Hodgkin's disease spreads to the spleen through the blood stream it is suggested that splenic involvement does not necessarily indicate that the involvement of other extralymphatic structures such as liver and marrow has occurred. However, when the nodes in the porta hepatis are involved splenic Hodgkin's disease may well be associated with an increased risk of occult hepatic infiltration.

Female↗
PubMedDate not supplied

The physiologic effects of eight weeks of aerobic dance with and without hand-held weights.

There are few reports concerning the physiologic alterations that occur following a specified period of aerobic dance. Further, no data exist to describe the physiologic changes or potential risk associated with using hand-held weights during aerobic dance. The purpose of this study was to determine the changes in maximum oxygen uptake (VO2max) and body composition following 8 weeks of aerobic dance using hand-held weights (Heavyhands, AMF, Jefferson, IA). Twenty-eight college females volunteered for the study. All subjects were given a preoxygen and postoxygen uptake (VO2 max) treadmill test. Body composition was measured by taking the sum of five skinfold sites and determining the percent change following training. Subjects were randomly assigned to a hand-held weight or nonhand-held weight group. No significant differences (P less than 0.05) existed between groups for VO2 max and body composition after 8 weeks of training. However, a significant improvement (P less than 0.05) in VO2 max was found within the hand-held weight (37.7 to 42.6) and in the nonhand-held weight group (36.5 to 41.9). Complaints from subjects included transient aches and pains in the shoulder area during the first 3 weeks as a result of hand-held weight use. These findings suggest that hand-held weights may be used safely but do not increase the work load sufficiently above that of aerobic dance alone to significantly modify VO2 max or body composition.

Adult↗
PubMedDate not supplied

Danazol treatment of advanced breast cancer.

Danazol, an effective agent in the treatment of benign breast disease, has been administrated to 41 patients with advanced breast cancer. These patients were treated with danazol for periods ranging from 1 to 40 weeks and responses were seen in seven of 41 (17%) patients. No responses were seen in the four premenopausal patients treated. Side effects were seen in nine of 41 (22%) patients, but in most patients these stopped when the dose of danazol was reduced. This preliminary study indicates that danazol may be an effective form of hormone treatment in patients with advanced breast cancer.

Adult↗