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PubMedDate not supplied

Uptake of aluminum and gallium into tissues of the rat: influence of antibody against the transferrin receptor.

Transport of aluminum and gallium from blood into rat tissues following continuous i.v. infusion of metals in different chemical forms has been investigated. Tissue uptake of aluminum and gallium was similar and highly dependent on the chemical species of the metals. Aluminum and gallium accumulated in liver and spleen when infused in the chloride form. Raised citrate markedly enhanced aluminum and gallium uptake into renal cortex and bone; in contrast with gallium-transferrin, citrate increased uptake of 67Ga into renal cortex and bone by 8- and 14-fold respectively. Uptake of 67Ga with citrate into renal cortex was around 3 times smaller than that of aluminum. The antitransferrin receptor antibody OX-26 enhanced 67Ga uptake from gallium citrate into all rat tissues. 67Ga from purified gallium-transferrin was also taken into all tissues in the presence of OX-26, the effect being greatest in renal cortex and bone. No influence of antibody on aluminum transport into rat tissues was, however, observed when aluminum was infused in the citrate form. Therefore, transport of aluminum and gallium into tissues is not similar under all conditions. Transport of each metal occurs into all tissues in the presence of antitransferrin receptor antibody. The potential for such transport is much greater in the case of gallium. Transport of aluminum and gallium citrate complexes appears important especially in the renal cortex and bone.

Aluminum↗

PubMedDate not supplied

Relative exposure of children to lead from dust and drinking water.

The Blackpool, Wyre and Fylde Health Authority, in the North West of England, could be described as a "low-level lead exposure area." Primary sources of lead exposure are atmospheric fallout (both indoors and outdoors) and potable water consumption. Deciduous teeth were collected from children living in this area as were water samples and outdoor dust samples. Both total lead concentrations and 206Pb:207Pb ratios were determined for a defined subset of teeth. Significant differences in the total lead concentrations were found for teeth collected from children resident in different targeted areas (i.e., Blackpool, Fleetwood, and Garstang). No significant differences were found between the total lead concentrations or the 206Pb:207Pb ratios from dust and water samples in these areas. Examination of the 206Pb:207Pb ratios for dust, water, and teeth obtained from each area separately revealed differing patterns of exposure to lead. Determination of 206Pb:207Pb ratios, in addition to total lead concentrations, enabled the differences in sources of exposure to be identified in these communities. The authors conclude that isotopic analyses are an important aspect of community survey work, and these analyses can be helpful in accurately targeting intervention strategies aimed at reducing exposure to lead.

Air Pollutants↗