Gastric acid secretion, as well as gastrin and pancreatic peptide release into the bloodstream before and after TV or HSV were observed in 28 patients following modified sham feeding (MSF) and pentagastrin tests. Prior to surgery the majority of patients showed stimulation of gastric acid secretion and hormone release into the bloodstream as the result of the employed tests. The MSF-induced acid output (SAO) and pentagastrin-induced acid output (PAOpg) values were mainly observed immediately following the stimulus. In the majority of patients MSF triggered an increase in blood gastrin and PP concentrations. Nevertheless, the peak concentration values for the two hormones occurred at different time intervals following the stimulus. For gastrin the peak values appeared later than SAO, whereas for PP they occurred either in the course of or immediately after MSF. Irrespectively of, the type of surgical procedure used and the completeness of vagotomy, the values of BAO, PAO, SAO and PAOpg were significantly lower following the procedure. Blood hormone concentration, however, showed greater variations. The test stimulated gastrin release showed the peak values were greater after, than prior to, the surgery, whereas PP release was markedly inhibited. No correlation was found between gastric acid secretion, blood serum gastrin and PP levels.

Adolescent↗

PubMedDate not supplied

Free amino acids in basal and vagally stimulated gastric secretion.

The concentrations of the individual free amino acids were determined in one hour fraction of basal secretion and peak hydrogen ion secretion following stimulation with 2-deoxy-D-glucose (2-DG) (group I) or insulin (group II). Group I consisted of 9 patients with duodenal ulcer having hypersecretion of gastric acid as determined by histamine test; 7 patients with duodenal ulcer who underwent truncal vagotomy and had insulin test performed two weeks after the operation formed group II. The total concentration of free amino acids was similar in basal and in stimulated gastric juice in both groups. Also the concentrations of the individual amino acids did not change significantly after stimulation. There was, however, a significant increase following stimulation in the output of amino acids both in group I and in group II. This increase was parallel to that in the volume of gastric juice, which suggests that a definite amount of free amino acids is always present in the gastric juice, and that the secretion of these acids is not under vagal control.

Amino Acids↗

PubMedDate not supplied

The effect of gluten-free diet supplemented with Humana-MCT on the level of lipid fractions in blood serum of infants with coeliac disease.

The concentrations of free fatty acids (FFA), triglycerides (TG), free cholesterol (FC) and estrified cholesterol (EC) as well as the fatty acid composition of TG and EC fractions have been determined in blood serum of 16 infants with coeliac disease. The determinations were carried out three times: after admission and diagnosis but before the initiation of any treatment, after two and after four weeks of a glutene-free diet supplemented with Humana-MCT formula. Before treatment all the infants had weight deficite between 20% and 40%. After two weeks of diet treatment, the concentrations of blood serum FFA and TG decreased as compared to those before the treatment. The highest values of EC were found during the third determination. The composition of fatty acids in TG and EC fractions did not change appreciably in the consecutive determinations. The absence of medium chain-length fatty acids in the studied lipid fractions despite steady supply in the diet suggests efficient metabolization of these acids in the liver. A considerable deficite of linoleic acid appearing in the infants studied before the treatment was not fully compensated during the four weeks of diet treatment.

Celiac Disease↗

PubMedDate not supplied

[Glucose and galactose tolerance tests in children with nephrotic syndrome. Blood sugar and level of plasma free fatty acids].

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Adolescent↗

PubMedDate not supplied

Gastric acid secretion and the changes of blood gastrin, glucose and insulin levels following 2-deoxy-D-glucose administration in hypersecretory and normosecretory duodenal ulcer patients.

Changes in gastric acid output, as well as the concentration of serum gastrin, blood glucose and serum insulin were measured in hypersecretory and normosecretory duodenal ulcer patients following 2-deoxy-D-glucose (2-DG) administration. The stimulation of gastric acid secretion caused by 2-DG was accompanied by a rise in serum gastrin and blood glucose concentrations. The values of serum gastrin measured during the test were significantly higher in hypersecretors. Despite high glucose level, there was no significant increase in serum insulin concentration both in hypersecretors and in normosecretors.

Adolescent↗

PubMedDate not supplied

Free amino acids of human gastric juice.

The concentration of free amino acids was determined with an amino acid analyzer in the basal and peak secretion fractions of gastric juice obtained from 20 duodenal ulcer patients. 20 amino acids were identified in both fractions, with 5 amino acids, i.e. histidine, glycine, phenylalanine, leucine, and glutamic acid constituting over 50 per cent of the total amino acid concentration. The total concentration of free amino acids in gastric juice, similar in both fractions was lower than in blood serum. The total output of free amino acids was significantly higher in the peak fraction as compared with the basal fraction. The analysis of the results obtained suggests that besides the direct contribution of blood plasma amino acid pool there are two other sources of gastric juice amino acids: secretion from the cells of gastric mucosa and intragastric hydrolysis of proteins and peptides present in gastric juice by concomitantly secreted gastric proteases. No correlation was found between the values of output and concentration of gastric juice amino acids and the correspondent values obtained for hydrogen ion secretion.

Adolescent↗

PubMedDate not supplied

Hydrolysis of milk triglycerides by human gastric lipase.

The concentrations of myristic, palmitic, palmitoleic, stearic and oleic acids were determined in the products of hydrolysis of lipids of cow milk incubated with human gastric juice using thin-layer chromatography for the separation of lipid fractions, and gas liquid chromatography for the determination of fatty acids. It was found that the percentage ratio of the above fatty acids in hydrolysis products was similar to that in milk triglycerides. It was concluded that triglycerides containing higher fatty acids present in milk are hydrolysed by the lipase appearing in human gastric juice, the rate of hydrolysis of the individual acids being roughly proportional to the concentration of these acids in triglyceride substrate.

Animals↗

PubMedDate not supplied

Effect of pentagastrin on in vitro growth of mucosal cells from human stomach and duodenum.

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Cells, Cultured↗