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Biomedical subjects

H Sugimura

Publications and source records attributed to H Sugimura.

197 records · Page 11Linked to original sources
PubMedDate not supplied

MRI of ossification of ligamentum flavum.

Magnetic resonance imaging of 28 patients with radiological and/or histopathologically proved ossification of the ligamentum flavum (OLF) was reviewed. The locations of OLF were cervical (n = 4), thoracic (n = 22), and lumbar (n = 2). On T1- and T2-weighted images, OLF demonstrated low signal intensity. Areas of high or intermediate signal intensity within the OLF on T1-weighted images were observed in three cases and were interpreted to be due to fat infiltration. In six cases, high intensity areas in the spinal cord caused by compressing OLF were demonstrated on T2-weighted images. Gadolinium-diethylenetriamine pentaacetic acid, which was used in four cases, showed cord enhancement at the level of compression by OLF in three cases.

Aged↗
PubMedDate not supplied

Optimal timing for delineation of hepatocellular carcinoma in dynamic CT.

OBJECTIVE: The aim of our study was to ascertain the optimal timing and scanning method for detecting hepatocellular carcinoma (HCC) as a high density mass during the early phase of dynamic hepatic CT and to confirm its clinical effectiveness. MATERIALS AND METHODS: We studied retrospectively 39 patients with clinically diagnosed HCC who underwent dynamic hepatic CT. RESULTS: All nine lesions that were scanned within 60 s after initiating injections were detected as high density masses. However, 15 of 21 lesions (71%) that were scanned > 70 s after initiating injections could not be detected as high density masses. Using helical scanning, which permitted scanning the entire liver within 60 s after initiating injections, 27 of 31 lesions (87%) were detected as high density masses. CONCLUSION: We concluded that most HCCs can be detected as high density masses during the early phase of dynamic CT using helical scanning.

Adult↗
PubMedDate not supplied

Bilateral breast tumors, malignant phyllodes tumor and invasive lobular carcinoma in a 46,XX/46,XY mosaic female with family history of breast cancer.

Bilateral breast tumors, a malignant phyllodes tumor in the right breast and an invasive lobular carcinoma in the left breast, occurred in a 47-year-old woman with 46XX/46XY mosaic karyotype in her peripheral blood lymphocytes and intersex external genitalia. Postmortem examination revealed bilateral ovotestis. Three of the patient's sisters also had breast cancer. In situ hybridization with a Y-specific probe revealed Y-chromosome-specific signal in both tumors, suggesting that the clonal origin of tumors in this patient was Y-containing cells. Androgen-receptor polymorphism also revealed a monoallelic X chromosome pattern in the recurrent phyllodes tumor tissue taken at autopsy, in addition to loss of heterozygosity demonstrated at locus TP53. The slippage of the CA repeats in the tumor was also shown at the loci of D5S82 and D11S527. The mechanistic basis for the occurrence of bilateral malignant tumors of the breast, XX/XY mosaicism, and familial clustering of breast cancer is still unknown. The present study, however, suggests that the sex chromosome abnormality may have modified the cancer phenotype in a manner similar to breast cancer in Klinefelter's syndrome (though phenotypically male) and the Y chromosome may have promoted cell growth.

Breast Neoplasms↗
PubMedDate not supplied

Nasolacrimal drainage system cyst in an adult.

A cyst of the nasolacrimal drainage system (NLDS) is rare in an adult. We report a case in a 29-year-old man of a mucous retention cyst of the NLDS, which appeared 2 years after the patient developed dacryocystitis coincident with an aggravation of chronic sinusitis. The lesion was successfully managed by removing the bony wall of the NLDS at the interface with the ethmoid and nasal cavity, as well as the membranous closure of the ostium of the common canaliculus. We speculate that the cyst development might have been initiated by inflammatory change such as mucosal adhesion in the NLDS resulting from the spread of secondary infection from the sinonasal tract.

Adult↗
PubMedDate not supplied

Relationship of p53 and Helicobacter pylori to clinicopathological features of human remnant stomach cancer after gastric surgery for primary gastric cancer.

The purpose of this study was to evaluate the biological features of gastric cancer of the remnant stomach (RSC). Twenty-one patients underwent resection of the remnant stomach for RSC and were divided into two groups: the RSCB group consisted of 11 patients who underwent distal gastrectomy for benign disease and the RSCM group consisted of 10 patients who underwent gastrectomy for primary gastric cancer. The interval between primary surgery and the appearance of gastric cancer in the remnant stomach was significantly shorter in the RSCM group than in the RSCB group. Invasion of adjacent organs was more frequent in the RSCM group than in the RSCB group and the Ki-67 labeling index of the tumors was significantly higher in the former group. Furthermore, p53 overexpression by tumors was almost twice as common in the RSCM group as in the RSCB group. Although there was no significant difference of the H. pylori positivity between the two groups, the rate for both groups was higher than reported in previous studies. Mutation of p53 may play an important role in the high proliferative activity of tumors in the RSCM group and H. pylori infection may be closely related to carcinogenesis in patients with RSC.

Adenocarcinoma↗
PubMedDate not supplied

Chemoradiation therapy for squamous cell carcinoma of anal canal cancer: report of a case.

We report a case of anal canal cancer in a 65-year-old woman who had complained of bloody stool. Physical examination revealed a 2.5 cm ulcerated tumor in the anterior wall of the anal canal astride the dentate line. Histological examination of biopsy specimens confirmed the diagnosis of moderately differentiated squamous cell carcinoma. Chemoradiation therapy included whole pelvic irradiation amounting to 4140 cGy followed by conformal boost irradiation of 2000 cGy and 5-fluorouracil div 750 mg/24 hr 3 days, mitomycin C iv 10 mg day 1, and cisplatinum div 50 mg day 2. Six weeks later the tumor had completely regressed, and there was no evidence of recurrence 21 months later. Her anorectal function was retained.

Aged↗
PubMedDate not supplied

Mucoceles of the paranasal sinuses with intracranial extension-postoperative course.

Mucoceles of the paranasal sinuses cause progressive distension of the bony walls and induce compressive symptoms. Although rare, cases of massive intracranial extension have occurred. We believe that an endoscopic transnasal approach is the best choice for such huge mucoceles because it is the least invasive and can provide an adequate surgical field of view for wide marsupialization. However, the results of long-term follow-up after endoscopic transnasal surgery have not been reported. This study was designed to evaluate prospectively the postoperative course of patients with intracranially extended mucocele. In the last 5 years, we have operated on four patients with intracranially extended mucocele. Although postopertive scanning is not recommended routinely after surgery for inflammatory disease, we followed up two patients who consented by using magnetic resonance imaging (MRI) along with endoscopy. Dural descent to the original skull base plane necessitated long periods of follow-up, lasting 18 and 5 months, respectively. On the mucocele wall mucosa, which had been smooth during surgery, polyps and granulations developed after surgical drainage and lasted for a considerable time. Although endoscopic transnasal opening of mucocele is a method of choice, we recommend follow-up of such patients for long periods, at least until the frontal skull base dura returns to its original position.

Aged↗
PubMedDate not supplied

The heme-binding region polymorphism of cytochrome P450IA1 (CypIA1), rather than the RsaI polymorphism of IIE1 (CypIIE1), is associated with lung cancer in Rio de Janeiro.

Ile-Val polymorphism in exon 7 of cytochrome P450IA1 (CypIA1) and RsaI polymorphism of cytochrome P450IIE1 (CypIIE1) were examined in a case-control study of lung cancer in Rio de Janeiro, Brazil. The Val-containing genotype in exon 7 of CypIA1 was found to be associated with lung cancer in this population (odds ratio, 2.26; 95% confidence interval, 1.14-4.47 for 99 cases versus 108 controls of 123 matched pairs), whereas RsaI polymorphism in CypIIE1 was not associated with lung cancer susceptibility. In squamous cell carcinoma, the degree of association of Val-containing genotype was greater in those with fewer pack-years of smoking. The RsaI polymorphism of CypIIE1 has a different distribution from the Japanese pattern and is not associated with lung cancer. When we analyzed the association of Ile-Val polymorphism to MspI polymorphism of CypIA1, the Val/Val homozygote was found only in the subpopulation with the MspI site-present homozygote. The apparent lack of association of CypIA1 MspI polymorphism with lung cancer in this area reported in our previous study and the results of the present study indicate that the "true" responsible site for lung cancer susceptibility should be the Ile-Val polymorphism in the catalytic site of CypIA1.

Brazil↗
PubMedDate not supplied

Lung cancer, race, and a CYP1A1 genetic polymorphism.

The assessment of human cancer risk using molecular epidemiological techniques involves determining the relative contributions of inherited and acquired genetic predispositions, in the context of environmental exposures. Recently described genetic polymorphisms for CYP1A1, a gene involved in the metabolic activation of polycyclic aromatic hydrocarbons, have been associated with lung cancer risk in a Japanese population. We report herein findings from a United States case-control study of lung cancer (56 cases; 48 controls). The polymerase chain reaction followed by an Msp1 restriction enzyme digestion was used to analyze constitutive DNA but no association between the restriction fragment length polymorphism and lung cancer risk was found (odds ratio, 0.7; 95% confidence interval, = 0.3-1.6). Analysis of genotype by cumulative smoking status did not reveal an elevated risk among lesser or greater smokers. The presence of the CYP1A1 Msp1 site-present allele, which was previously found to be associated with Japanese lung cancer risk, was statistically increased in African compared to Caucasian Americans (odds ratio, 2.9; 95% confidence interval, 1.2-2.7). When stratified by race, however, no association between case status and the polymorphism was observed, but the small number of study subjects within each racial group limited the statistical power. Larger studies are required to evaluate the risk of the CYP1A1 Msp1 polymorphism in African Americans.

Asthma↗
PubMedDate not supplied

Repositioning of a displaced catheter for percutaneous hepatic arterial infusion chemotherapy.

This is a report of a patient with hepatocellular carcinoma whose hepatic arterial catheter, which was introduced via a subclavian arterial branch, migrated into his right gastric artery. The catheter was successfully maneuvered to a suitable position without any further invasive procedure. The importance of preparatory embolization of the right gastric artery is underscored.

Carcinoma, Hepatocellular↗
PubMedDate not supplied

Meningeal hemangiopericytoma metastatic to the heart.

We report for the first time the metastasis of intracranial hemangiopericytoma to the heart. In evaluating cardiac conditions, MRI provided useful information regarding the location and features of paracardiac tumors.

Female↗
PubMedDate not supplied

Motion related artifacts in spin-echo MR imaging: effects of sequence parameters on image quality at 1.5 Tesla.

PURPOSE: The purpose of this study was to evaluate the effects of selected parameters in a conventional spin-echo MRI sequence on image quality in a phantom undergoing periodic motion. METHODS: Images of a composite oil/copper sulfate phantom moving in a 1.5 Tesla magnet were acquired. The CuSO4 ghost signal-to-noise ratio (SNR) and distances between corresponding points on the phantom image and adjacent ghosts were evaluated. RESULTS: Increasing time to repeat (TR) and number of acquisitions (NAq) improved image quality. Ghost SNR was near unity at TR = 500 msec and at NAq around 4. Increasing TR and NAq resulted in increased distance between images. The effects of field of view (FOV) and matrix size on image quality were relatively less significant. CONCLUSION: Increasing NAq appeared to have a comparatively greater effect on ghost SNR and image quality under our experimental conditions. However, the effect of increasing NAq on image quality appeared to be definite since a saturation point was reached after a particular NAq. Increasing NAq above this point resulted in a relatively smaller improvement in image quality.

Artifacts↗
PubMedDate not supplied

Pituitary prolactinoma mimicking tumor originating from the sphenoid sinus or clivus.

We report a case of a pituitary prolactinoma mimicking a sphenoid sinus or clival tumor. On magnetic resonance (MR) images, a soft tissue mass located inferior to the apparently normal pituitary gland, and occupied the posterior third of the sphenoid sinus and eroded the upper portion of the clivus. It had iso- to low intensity on the T1-weighted image, and slightly high intensity on the T2-weighted image. Careful observation revealed that the floor of the sella turcica was not identified and there was sulcus formation between the tumor and clivus, probably suggesting extraclival tumor, pituitary tumor. Transsphenoidal tumor resection and histopathological study revealed that it was a prolactinoma.

Cranial Fossa, Posterior↗
PubMedDate not supplied

Adult cystic Wilms' tumor (nephroblastoma): radiologic features with pathologic correlation.

Wilms' tumor is an uncommon disease in adults. Wilms' tumor typically presents as a large complex mass with cystic component and varying degrees of vascularity. The previously reported radiologic findings have reflected this complex appearance. We present a case of cystic Wilms' tumor in an adult patient. The tumor presented as a large, rapidly growing, hypovascular, multicystic mass with minimal solid component which showed as septation on ultrasound, contrast enhanced CT, and MR studies. The preoperative findings were suggestive of multilocular cystic nephroma. We suggest that Wilms' tumor should be included in the differential diagnosis of a patient who presents with a large, rapidly growing, multicystic renal mass.

Adult↗
PubMedDate not supplied

Lipiodolized gelatin sponge: a simple method to make gelatin sponge radiopaque.

Gelatin sponge particles were rendered radiopaque by soaking them in small amounts of iodized oil (LP-GS). They were evaluated for their usefulness in transarterial embolization (TAE). The LP-GS particles were well visualized fluoroscopically during TAE. The duration of the opacity of LP-GS exceeded 24 hours both in vitro and in vivo. LP-GS are useful, and are an easily obtainable, radiopaque, embolic material.

Contrast Media↗
PubMedDate not supplied

Percutaneous transluminal renal angioplasty of arterial divarication: application of kissing balloon technique.

We present a patient with renal artery stenoses due to fibromuscular dysplasia involving the point of arterial bifurcation that we could successfully dilate with percutaneous transluminal angioplasty. We used the kissing balloon technique to prevent possible complications of percutaneous transluminal renal angioplasty (PTRA), including occlusion of the other branch while dilating one branch. The kissing balloon technique worked well for PTRA of the arterial bifurcation.

Adolescent↗