Biomedical subjects

H Sugihara

Publications and source records attributed to H Sugihara.

544 records · Page 31Linked to original sources

PubMedDate not supplied

Cerebral angiography and ultrasonic quantitative flow measurement of common carotid artery in patients with cerebral infarction.

Blood flow rate and velocity in the common carotid artery were measured with an ultrasonic quantitative flow measurement (QFM) system and cerebral angiography was performed in 98 patients about four weeks after the onset of cerebral infarction. Angiography revealed complete occlusion in 13 patients (CO group), visible stenosis in 45 patients (S group), and no apparent stenosis in 40 patients (N group). In the CO group, damaged-side blood flow (DF; 4.80 ml/sec) and velocity (DV; 10.5 cm/sec) were significantly lower (P less than 0.01) than intact-side blood flow (7.19 ml/sec) and velocity (14.86 cm/sec). Both DF and DV were significantly lower in group CO than group S (7.55 ml/sec and 15.04 cm/sec) and in group S than group N (9.32 ml/sec and 18.07 cm/sec). Degree of stenosis in the internal carotid and middle cerebral arteries was significantly associated with reduced DF (P less than 0.05). Of the 24 patients with a mean DF of under 6.5 ml/sec, 15 had stenosis of 75% or more; of the 74 patients with a mean DF of 6.5 ml/sec or more, 66 had stenosis of less than 25%. The results indicate that blood flow determined by QFM reflects the degree of occlusion or stenosis in the intracranial trunk arteries and may thus provide a practical, noninvasive method of assessing the severity of cerebrovascular lesions.

Acute Disease↗

PubMedDate not supplied

[Myocardial ischemia and abnormality of cardiac sympathetic nervous function in apical hypertrophic cardiomyopathy].

Exercise 201Tl myocardial scintigraphy of patients with apical hypertrophic cardiomyopathy (AH) often shows transient perfusion defect in the apex. Catecholamine may be related to the pathogenesis of AH, but this is not certain. The relationship between hypertrophy, myocardial ischemia, and cardiac sympathetic nervous function were investigated by comparing 123I-MIBG myocardial SPECT with exercise 201Tl myocardial SPECT especially at the apex which is the hypertrophic region. Seventeen patients with AH, mean age of 53 +/- 11 years old, underwent 123I-MIBG myocardial SPECT and exercise 201Tl myocardial SPECT on separate days. Decreased tracer uptake regions and the severity and extent of the defect were evaluated visually and compared. Myocardial clearance of 123I-MIBG in apical, midventricular, and basal regions was calculated from the bull's eye display. 123I-MIBG SPECT showed a decreased uptake or defect in the apex of all patients. 201Tl SPECT showed a reversible perfusion defect in the apex of 10 patients, an irreversible perfusion defect in the apex in 3, and normal perfusion in 4. Comparing decreased uptake on the exercise 201Tl myocardial image and 123I-MIBG 4-hour delayed image, the severity of the defect was: MIBG > Tl in 12 patients (71%), MIBG = Tl in 5 (29%), and the extent of the defect was: MIBG > Tl in 11 (65%), MIBG = Tl in 6 (35%). Mean clearance of 123I-MIBG in the apical and midventricular regions was significantly higher than that in the basal region (apical 46.2 +/- 7.1%, midventricular 44.4 +/- 7.8%, basal 38.7 +/- 7.7%).(ABSTRACT TRUNCATED AT 250 WORDS)

3-Iodobenzylguanidine↗

PubMedDate not supplied

[Effect of verapamil on myocardial ischemia in patients with hypertrophic cardiomyopathy: evaluation by exercise thallium-201 SPECT].

The effect of verapamil on myocardial ischemia in patients with hypertrophic cardiomyopathy (HCM) was evaluated by exercise myocardial 201Tl SPECT (EX-Tl). EX-Tl was performed before and after 8.1 +/- 6.1 weeks of oral administration of verapamil (240 mg/day) on 20 patients with HCM who showed transient 201Tl perfusion defects under control conditions. SPECT images were divided into nine segments. The 201Tl perfusion defect was visually scored and evaluated for four grades in each segment and the sum total grade was calculated as the defect score. Transient dilation index was calculated as a reflection of subendocardial ischemia. Improvements in defect score were demonstrated in 18 of 20 patients after administration of verapamil. The mean defect score decreased significantly from 5.1 +/- 2.3 to 2.5 +/- 2.4 (p < 0.001). Although 18 of 20 patients showed abnormal transient dilation index under control conditions, 16 showed improvement and 12 were normalized after verapamil therapy. Mean transient dilation index decreased from 1.24 +/- 0.19 to 1.08 +/- 0.10 (p < 0.01). Verapamil improves myocardial ischemia in patients with HCM.

Cardiomyopathy, Hypertrophic↗

PubMedDate not supplied

Superficial spreading type of early gastric lymphomas.

Recent advances in diagnostic techniques have increased the apparent incidence of gastric lymphomas at an early stage. However, the clinical features of the superficial spreading type of early gastric lymphoma are not well-documented. We retrospectively examined the clinicopathologic features of 5 patients with the superficial spreading type of early gastric lymphoma. These tumours were MALTomas which had a characteristically difficult diagnosis and indistinct tumour margins, and a high incidence of lymph node involvement was found. We conclude that satisfactory treatment of this neoplasm requires a wide resection of the stomach with extensive lymph node dissection.

Adult↗