Biomedical subjects
Publications and source records attributed to H Suenaga.
We report a rare case of primary malignant lymphoma of the esophagus. The 45-year-old patient was followed up radiologically and endoscopically for 3 months prior to operation.
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Plate (or slope) cultures of endomycin-producing Streptomyces endus (KCC S-0213) showed spontaneously developing pocks which increased in number during subculturing. Neither spore formation nor typical aerial hyphae formation was observed in the pocks, whereas formation of substrate hyphase was not inhibited. Almost all of the hyphae were broken or lysed in the pocks, and many phage tail tiplike particles were observed in the pocks. No self-replication activity was associated with the particles. The particles often formed a hexagonal crystal or a large crystal mass. The production of these particles did not occur in the liquid culture or in young or normal plate cultures having no pocks. These results were similar to those obtained from the plaque-making phenomenon, except for active phage production, in thiostrepton-producing Streptomyces azureus (ATCC 14921), which has been described previously.
Slope (or plate) cultures of thiostrepton-producing Streptomyces azureus (ATCC 14921) often showed spontaneously developing plaques. Plaques increased in number during serial subcultures. The production of aerial mycelia and sporulating aerial hyphae was interrupted by the overlapping plaques, whereas the growth of substrate mycelia continued in the plaques. These abnormal (eroded) cultures were easily restored to their normal conditions once they were passed through liquid cultures under shaking conditions. A few phage particles were found in the plaques, together with some headless tails and numerous tail tips which formed a hexagonal crystal or a large crystal mass when viewed in an electron microscope. No lytic phenomenon and no phage production were found in the liquid cultures, although all mycelia and spores harbored phage-producing abilities. It was also found that the propagation of phages was successful in solid culture, but not in liquid culture. The whole phage was named SAt2, which belongs to group B of Bradley's morphological classification. From these results, it is considered that S. azureus is lysogenic with temperate phage SAt2, of which virulent mutants are able to infect the aerial mycelia and sporulating hyphae of their lysogenic host.
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We describe a 51 year-old man with calcified early gastric cancer. The calcification was not displayed by abdominal X-ray, CT, or conventional ultrasound. Only endoscopic ultrasonography displayed the distribution of calcification in vivo. Endoscopic ultrasonography revealed a slightly hypoechoic lesion with a high echoic line, without involvement of the fourth layer. Histopathologically, it was a IIc type early gastric cancer. The depth of cancer invasion was limited to the mucosa and a mucin pool was not observed. Psammomatous calcification was observed in the lumen of the carcinomatous glands. This seems to be the first case reported in which psammoma bodies were observed in early gastric cancer.