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Biomedical subjects

H Suda

Publications and source records attributed to H Suda.

At least 289 records · Page 16Linked to original sources
PubMed1983

[Micrometastasis in the resected lungs of lung cancer patients with special reference to their clinical features].

The microscopic metastases were examined seemingly unaffected areas of the resected lungs in 116 primary lung cancer patients. In 55 patients (47%), micrometastases were found in the areas which looked normal. The investigation on the route and location of micrometastaes revealed that lung metastases were formed mainly through haematogenous and partly through lymphatic route. The high incidence of postoperative intrapulmonary spread in the positive micrometastasis group suggested that most of microscopic deposits would become distinct tumors in time. Thirteen patients have had a second operation for the intrapulmonary metastatic lesions. There was one postoperative death. Nine patients have subsequently died. Three patients are still alive and well without evidence of recurrence.

Adenocarcinoma↗
PubMed1983

White spots of the liver in pigs experimentally infected with Ascaris suum.

To make clear the relationship between Ascaris suum infection and the appearance of white spot lesions on the surface of the liver in pigs, three groups of pigs were inoculated orally with embryonated A. suum eggs and observed clinicopathologically. Group A of three pigs were inoculated 21 times with 100 eggs each of the nematode, group B of three pigs 4 times with 50,000 eggs each for 10 weeks, and group C of two pigs 2 times with 50,000 eggs each at a one-week interval. All the pigs were sacrificed at the same time 1 week after the final inoculation. Such signs of the nematode infection as dyspnea, coughing and fever appeared in all the pigs of groups B and C seven days after inoculation to continue for several days. In addition, peripheral blood eosinophilia was recorded in these animals 7 or 14 days after inoculation. At autopsy, mesh-worked white spots, some compact and others lymphonodular, were observed on the surface of the liver in all the pigs of the three groups. Main white spots were mesh-worked and lymphonodular in the pigs of group A. They were severe and compact in group B. Therefore, they were rough to the touch. In group C mesh-worked white spots fused with one another and covered the surface of the liver. These white spot lesions observed were morphologically very similar to those found in the field conditions. Complement-fixating antibodies reacting to adult A. suum antigen were detected only in sera from the pigs of group B. Moreover, antibodies involved in the intradermal reaction of immediate type were found in the pigs of groups A and B.

Animals↗
PubMed1983

Pathological studies on white spots of the liver in fattening pigs.

Hepatic lesions were found in fattening pigs derived from a farm where swine had been suffering from the multiple occurrence of white spots in the liver. They were examined at a slaughter-house for 18 months. The white spots were classified into three patterns on the basis of the macroscopic appearance; that is a compact, a mesh-worked, and a lymphonodular pattern. Histologically, the following 3 kinds of lesions were seen: (1) Eosinophilic interstitial hepatitis accompanied with intralobular necrosis, arteriolar degeneration, boring focus, granuloma and the existence of Nematoda larvae. (2) Fibrosis accompanied occasionally with infiltration of a few eosinophils and lymphocytes. (3) Lymphofollicular hyperplasia. As to the relationship between macroscopic and histologic patterns, compact white spots were generally produced by eosinophilic interstitial hepatitis. The mesh-worked pattern consisted of eosinophilic interstitial hepatitis or fibrosis, and the lymphonodular pattern of lymphofollicular hyperplasia. The incidence of eosinophilic interstitial hepatitis was relatively high over a period from July to December and rather low over a period from January to June. That of fibrosis was considerably high all the year round. Lymphofollicular hyperplasia showed no distinct seasonal incidence. Intestinal ascarids were frequently detected over a period from August to October. Pigs having CF antibody against Ascaris suum increased in number over a period from August to December. From these results, the cause of the multiple occurrence of white spots in the liver was regarded as A. suum infection.

Animals↗
PubMed1982

[Potentiative effects of angiotensin converting enzyme inhibitors on carrageenan-induced edema in rats].

Carrageenan-induced edema of rat paw was greatly potentiated by orally or locally administered angiotensin converting enzyme (CE, identical with kininase II) inhibitor, (4R)-3-[(2S)-3-mercapto-2-methylpropanoyl]-4-thiazolidinecarboxylic acid (YS980). The potentiative effect of YS980 was observed by the administration not only prior to but also 3 hr after the carrageenan injection. The vascular permeability test showed the same potentiative effect of YS980 in the inflamed tissue of carrageenan edema. Bradykinin potentiating peptide-B (BPP-B) and 1,10-phenanthroline also potentiated the edema and the effects of these compounds were in order of YS980 greater than BPP-B greater than 1,10-phenanthroline. The order was in accordance with that of inhibitory potencies against kininase II activity of rat serum in vitro. However, the activity of kininase I was not affected by YS980 and BPP-B. In addition, among various experimental models of acute paw edema, the potentiative effects of YS980 were restricted to the inflammations mediated by kinins such as carrageenan, cellulose sulfate, kaolin and bradykinin-induced edema. These results suggest that the potentiative effect of YS980 on carrageenan edema is mainly based on its inhibitory effect on kininase II in the inflamed site.

3-Mercaptopropionic Acid↗
PubMed1981

A new potent inhibitor of converting enzyme: (2R,4R)-2-(2-hydroxyphenyl)-3-(3-mercaptopropionyl)-4-thiazolidinecarboxylic acid(SA446).

(2R, 4R)-2-(2-Hydroxyphenyl)-3-(3-mercaptopropionyl)-4-thiazolidinecarboxylic acid (SA446) is a novel potent converting enzyme inhibitor having a sulfhydryl group in the molecule. SA446 inhibited the activity of semi-purified rabbit lung converting enzyme (IC50 = 6 nM). The contractile response of isolated guinea pig ileum to angiotensin I (AI) was markedly inhibited by SA446 (IC50 = 28 nM). On the other hand, SA446 augmented the contraction to bradykinin (BK) (AC50 = 0.7 nM), but did not affect the contraction caused by angiotensin II (AII), acetylcholine and histamine. These in vitro potencies of SA446 were 4 to 5 times larger than those of captopril. SA446 inhibited the pressor response to AI in rats (ID50 = 0.06 mg/kg, i.v., 0.48 mg/kg, p.o.) and dogs (ID50 = 0.01 mg/kg, i.v.). SA446 augmented the depressor response to BK (AD50 = 0.009 mg/kg, i.v.), but did not affect the pressor responses to AII and norepinephrine in rats. These in vivo activities of SA446 in dogs were more potent than those of captopril, but the reverse was seen in rats. Oral administration of SA446 had a hypotensive effect on two-kidney, one-clip renal hypertensive rats and spontaneously hypertensive rats, at doses over 3 and 10 mg/kg, respectively. However, the blood pressure of normotensive and DOCA-salt hypertensive rats was not affected by SA446, in doses up to 100 mg/kg. These results indicate that oral SA446 is a potent active inhibitor of converting enzyme and may be classed as an antihypertensive agent.

3-Mercaptopropionic Acid↗
PubMed1980

Purification and properties of N-formylmethionine aminopeptidase from rat liver.

A specific enzyme for the liberation of N-terminal N-formylmethionine from N-formylmethionyl peptides was purified 4750-fold from rat liver by successive applications of (NH4)SO4 precipitation, DEAE-cellulose, N-formylbestatin-AH-Sepharose 4B and AH-Sepharose 4B chromatography followed by Sepharose CL-6B gel filtration. The molecular weight was determined by gel filtration on Sepharose CL-6B as 290 000 +/- 5000. This was suggested to be a tetramer consisting of a subunit which was shown by sodium dodecyl sulphate (SDS)-polyacrylamide gel electrophoresis to have a 72 000 +/- 2000 molecular weight. The optimum pH of the enzyme was 7.8. Cd2+ and Hg2+ were highly toxic to the enzyme. Michaelis constants of N-formylmethionyl leucine and N-formylmethionine beta-naphthylamide were 0.03 and 0.2 mM, respectively.

Aminopeptidases↗
PubMed1980

Antianaphylactic effects of dipivalyl epinephrine and related compounds in rat conjunctiva.

Topically applied dipivalyl epinephrine (DPE) and related compounds have been found to inhibit passive anaphylactic reaction in rat conjunctiva. The order of activity is as follows: isoproterenol greater than DPE greater than epinephrine greater than norepinephrine. The antianaphylactic effect of DPE was antagonized by propranolol but was not affected by phentolamine. The effects of epinephrine, norepinephrine, and isoproterenol were also antagonized by propranolol but potentiated by pentolamine. From these findings, it was suggested that DPE not only exerts its antianaphylactic action through activation of beta-adrenergic receptor but also itself has a little different action from epinephrine.

Anaphylaxis↗