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Biomedical subjects

H Stormorken

Publications and source records attributed to H Stormorken.

At least 55 records · Page 3Linked to original sources
PubMed1989

[Progress in the treatment of mild hemophilia. Liberation of factor VIII from the vascular endothelium with 1-desamino-8-D-arginine vasopressin].

Sufficient increase in plasma of factor VIII activities with a view to carrying out surgery in mild and moderate Haemophilia A and von Willebrand's disease was achieved by intravenous infusion of 1-desamino-8-D-arginine vasopressin (DDAVP). 15 patients were treated with success and three patients had to be transfused with factor VIII concentrates to control postoperative hemorrhage. DDAVP therapy makes transfusion unnecessary in selected patients. This is an important therapeutic advance as long as the use of blood products does involve danger of infecting the recipient. Another advantage is that DDAVP therapy is much cheaper than factor VIII concentrate.

Adolescent↗
PubMed1988

Effects of contrast media on the hemostatic and thrombotic mechanisms.

The hemostatic and thrombotic mechanisms represent complex biologic systems. When a vessel is severed, a platelet plug begins to form, followed by activation of the coagulation mechanism to form thrombin, which converts fibrinogen to fibrin. The formation of thrombin also requires platelet coagulant activities, which help keep fibrin formation localized at the site of vessel wall damage. The thrombo-hemorrhagic balance represents a complicated homeostatic biologic system; this system has many control mechanisms, but its balance is rather fragile. Our studies show that the new nonionic contrast media induce far fewer changes in the thrombo-hemorrhagic balance than the ionic media.

Blood Coagulation↗
PubMed1988

Lupus anticoagulant: a unique case with lupus anticoagulant and habitual abortion together with antifactor II antibody and bleeding tendency.

Lupus anticoagulants (LA) are associated with various forms of thrombotic events. Of particular interest to obstetrics is the association with placental infarcts and habitual abortion. In the case described a near full-term viable infant was delivered subsequent to four early miscarriages. However, the mother had then developed an antifactor II antibody leading to grave hypoprothrombinemia with bleeding tendency, indicating efficient autoanticoagulation. This natural experiment indicates that these patients should receive anticoagulation during pregnancy, possibly in combination with steroids to depress the LA level.

Abortion, Habitual↗
PubMed1987

Dissociation of the aggregating effect and the inhibitory effect upon cyclic adenosine monophosphate accumulation by adrenaline and adenosine diphosphate in human platelets.

Recent evidence indicates that adrenaline and adenosine diphosphate each have separate stimulus-response pathways for induction of aggregation and inhibition of cAMP accumulation. We have used a natural model to test the validity of this evidence, i.e. patients from two kindreds with an inherited bleeding disorder due to absent aggregation to adrenaline and no secondary wave response to large concentrations of adenosine diphosphate. Our studies showed that the inhibitory effect of adrenaline and adenosine diphosphate on PGE1-induced increase of cAMP in the patients was not different from that of the controls both for adrenaline and adenosine diphosphate. These results therefore support the present evidence that both adrenaline and adenosine diphosphate apply separate pathways in these two platelet functions.

Adenosine Diphosphate↗
PubMed1987

The hemostatic mechanism: the role of platelets in physiology and bleeding states.

The most recent information about platelets and their role in hemostasis is presented. The intimate cooperation between platelets, coagulation, and the vessel wall (the thrombohemorrhagic balance) is outlined. Clinical correlates (congenital and acquired bleeding states) to the various physiological stages and the possible effects on hemostasis of the unique acidic environment of the stomach are briefly discussed.

Blood Coagulation↗
PubMed1987

Pharmacologic effects of iopentol after intravenous injection in healthy volunteers. Preliminary report.

The effects of the first injections in humans of iopentol, a new non-ionic contrast medium, are briefly reported. Detailed descriptions will be published elsewhere. Iopentol was well tolerated when injected intravenously into 24 healthy male volunteers in doses of 300 to 1,200 mg I/kg body weight and was excreted almost entirely in the urine in unchanged form. The results indicate that iopentol may be used in clinical trials in patients.

Adult↗
PubMed1987

Effect of iopentol on coagulation and platelet function in vitro and in vivo.

The effect on hemostatic parameters of two non-ionic contrast media, iopentol and iohexol in concentrations of 350 mg I/ml, were tested in vitro. The new medium iopentol had similar effects to those of iohexol, both with respect to the intrinsic coagulation system and platelet aggregation. As part of a human pharmacologic study the effects of iopentol on hemostatic parameters were tested in 8 volunteers in vivo. Iopentol induced a slightly decreased coagulability and aggregability in venous blood. It was concluded that the effects were of very little consequence for hemostasis as a whole.

Blood Coagulation↗
PubMed1986

Visualization of von Willebrand factor multimers by enzyme-conjugated secondary antibodies.

A method for visualization of the multimeric forms of von Willebrand Factor (vWF) in plasma and platelets is described. The method is based upon: 1) Separation of the vWF multimers by SDS-agarose electrophoresis, 2) Subsequent blotting of the vWF multimers onto nitrocellulose, 3) Immunolocalization and visualization of the vWF pattern by the sequential incubation of the blot with primary vWF antiserum, peroxidase- or beta-galactosidase-conjugated secondary antibodies and a relevant chromogenic substrate.

Antibodies↗
PubMed1986

Effect of various contrast media on coagulation, fibrinolysis, and platelet function. An in vitro and in vivo study.

An in vitro and in vivo study of the effect of ionic and nonionic contrast media (CM) on coagulation and platelet function is reported. The methods employed were tests for extrinsic and intrinsic coagulation together with a fibrinolytic parameter and aggregation using ADP and collagen as inducers. The in vivo study utilized patients undergoing routine cerebral angiography. The in vitro results showed a modest influence of the nonionic CM in contrast to the ionic. The marked inhibitory effect of the latter was mainly caused by inherent toxicity, osmolality/ionic strength being of minor importance. The in vivo results showed a negligible influence of CM on systemic hemostatic parameters, but catheter-derived samples indicated desirability of premedication with ASA or heparin. The nonionic CM caused less discomfort than the ionic CM.

Blood Coagulation↗
PubMed1986

Increased binding to ADP-stimulated platelets and aggregation effect of the dysfibrinogen Oslo I as compared with normal fibrinogen.

Interactions of the dysfibrinogen Oslo I with platelets were investigated. This fibrinogen is a B beta-chain variant with faster than normal fibrin monomer polymerization. Fibrinogen Oslo I acted more efficiently in ADP-induced platelet aggregation, and bound to gel-filtered platelets with a higher affinity constant than did normal fibrinogen. At all concentrations more fibrinogen molecules became bound per platelet with the dysfibrinogen than with normal fibrinogen, both when the fibrinogens were tested separately or as a mixture using 125I or 131I to label the two types. At high concentrations this was probably due to ligand polymerization of the dysfibrinogen. These observations indicate that the increased cofactor function in platelet aggregation may be related to the increased affinity of the dysfibrinogen for the platelets.

Adenosine Diphosphate↗