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Biomedical subjects

H Sterz

Publications and source records attributed to H Sterz.

At least 37 records · Page 2Linked to original sources
PubMed1984

[Chronic circulatory disorders].

For all parts of the body the clinical picture of obstructive vascular disease is decisive. Invasive diagnostic techniques are only advisable if surgical treatment is considered. Angiography reveals only the site of the obstruction and the run-off-situation in operable cases. In cerebral and in coronary surgery operations can only be recommended if the tissue behind the obstruction is still alive; whether necrotic brain nor dead myocardium can be reanimated by revascularisation. Cerebral and coronary vascular surgery have therefore more prophylactic intentions. In peripheral arterial obstructions an operation should save the leg but not treat intermittent claudication.

Angioplasty, Balloon↗
PubMed1984

Ro 15-1570, a new sulfur-containing retinoid devoid of bone toxicity in rats.

Repeated ingestion of high doses of retinoids cause the so-called hypervitaminosis A syndrome. In rats the main symptoms are weight loss, alopecia, erythema, desquamation of the skin, and alterations of the skeletal system, including bone fractures. In the present study, three retinoids (Ro 15-1570, arotinoid ethylsulfone, 6 mg/kg; retinoic acid, 100 mg/kg and etretinate, 50 mg/kg) were administered orally to rats for 1 and 2 weeks, respectively, to six male and six female rats/group. All the above changes were induced by all three retinoids, with the exception that the arotinoid ethylsulfone Ro 15-1570 did not cause bone alterations. The absence of toxic effects on the bones by Ro 15-1570 was confirmed by X-ray-film examinations, densitometry of the X-rayed femora and tibiae, examination of the thickness of the femoral and tibial compacta in histological slides plus the determination of the femoral ash weight and its main inorganic constituents (calcium, magnesium, sodium, and potassium). The present demonstration that the arotinoid ethylsulfone Ro 15-1570 was devoid of bone toxicity constitutes major progress in the pharmacologic development of retinoids with a better balance between therapeutic and adverse effects.

Animals↗
PubMed1980

[Unusual cause of an arteriovenous coronary fistula (author's transl)].

Shortly after a febrile "flu" a systolo-diastolic murmur was heard in a 25-year-old female. Clinically a ruptured sinus-Valsalva aneurysm was assumed. Coronary angiography revealed a fistula between the right coronary artery and the right atrium. A density on X-ray along a rib led to a biopsy and the specimen showed an angiosarcoma. Very fast growing and spreading into the lungs, liver and many bones caused death 6 months after onset. Autopsy showed many metastases from an angiosarcoma and a fistula between the right coronary artery and the right atrium due to sarcomatous masses.

Adult↗
PubMed1978

[Transesophageal rapid stimulation of the left atrium in atrial tachycardias (author's transl)].

A new method to interrupt atrial tachycardias is reported. With an esophageal double-electrode the left atrium is stimulated with an external pacemaker at rates of 400 per minute and with 10 to 20 mAmp; The rhythm-disturbances treated in this way were: atrial tachycardias with constant or inconstant blocks and paroxysmal supraventricular tachycardias. 7 of 9 cases reported showed positive results, i.e. electrically induced atrial fibrillation and sinusrhythm immediately or within the first hour after stopping the pacer (6) or atrial fibrillation after disconnection from the pacer at a lower heart-rate than before (1). In 2 cases the technique was applied without success. The transoesophageal rapid left atrial stimulation (oeRLAS) is painless, can be applied without sterile measures and even without X-ray-control just by observing the oesophageal Ecg. Digitalisation is unimportant. The technique described may prove useful in cases of atrial tachycardias esp; in intensive care units.

Atrial Flutter↗
PubMed1977

[Percutaneous implantation of permanent pacemakers (author's transl)].

2 methods for the implantation of permanent pacemakers with percutaneous puncture of the subclavian vein are described. The first one was used in 44 patients with the aid of an introducing catheter-set Desilets-Hoffman consisting of guide-wire, inner Teflon dummy catheter and outer thin-walled sheath; through this a shoulder-less electrode catheter no. 8 could be inserted for permanent pacing. The other technique was applied to 20 patients and used thinner special electrodes no. 6F, which could be introduced directly through a plastic cannula inserted with a puncture-needle. The advantages are: diminished risk of infections, local anesthesia instead of general anesthesia, applicability by the cardiologist in the catheterization-laboratory or under a simple fluoroscopy-unit, short stay of patients in the hospital without transfers to other departments, few personnel (1 scrubbed doctor, 1 non-scrubbed nurse), recognition of venous anomalies (singular left superior caval vein) without useless incisions for the patient. Complications such as pneumothorax, puncture of the subclavian artery, and dislocations of the electrodes have also been encountered.

Anesthesia, Local↗