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Biomedical subjects

H Stern

Publications and source records attributed to H Stern.

At least 163 records · Page 9Linked to original sources
PubMed1977

Intrathoracic goitre: a cause of the superior vena cava syndrome.

Benign lesions of the mediastinum rarely produce obstruction of the innominate vessels. Two patients with intrathoracic goitre are described who presented with the superior vena cava syndrome. Venography in each case demonstrated the extent of obstruction and degree of collateral circulation. Early recognition of the association of intrathoracic goitre and superior vena caval obstruction may lead to clinical improvement with surgical treatment.

Aged↗
PubMed1977

Cytomegalovirus infection in the neonate and its prevention.

About 0.5% of infants are infected in utero with cytomegalovirus (CMV). As many as 20% become mentally retarded and a further substantial proportion suffer lesser degrees of brain damage. The need for a vaccine is greater than in the case of rubella. A live, tissue culture-adapted strain of CMV has been shown to produce neutralizing antibody in volunteers without significant side effects or detectable virus excretion. The problems of developing such a vaccine for use in man, namely, attenuation, antigenic differences among virus strains, reactivation of latent infection and oncogenicity, are briefly discussed.

Antibody Formation↗
PubMed1977

The lateral view in radionuclide imaging of the sacrum.

Radionuclide bone images in the anterior and posterior views failed to demonstrate a large metastatic tumor involving the sacrum which was obvious on the lateral view. Evaluation of the sacrum by radionuclide imaging may be incomplete without the lateral projection, particularly when there is a question of false-negative anterior and posterior views or difficulty in interpreting the radionuclide images.

Adult↗
PubMed1977

A simple approach to the diagnosis of bronchopleural fistula.

The authors describe a simple, yet reliable technique for confirmation of a bronchopleural fistula. It is based on detection of radioactivity in the pleural space after the washout phase of the 133Xe ventilation study. This method demonstrated the pathological communication while bronchoscopy, bronchography, and methylene blue testing did not.

Bronchial Fistula↗
PubMed1976

Pulmonary embolism and intracardiac shunt: a unique indication for operation.

Pulmonary embolism with right-to-left intracardiac shunt presents a special problem for the clinician. A review of the literature and 4 personal cases, all diagnosed antemortem, are presented. On the basis of this information certain conclusions are drawn, and we suggest the problem to be a unique indication for the consideration of surgical intervention.

Adult↗
PubMed1975

Presynaptic events in meiocytes of Lilium longiflorum and their relation to crossing-over: a preselection hypothesis.

We are proposing a "Preselection Hypothesis" to account for the regulation of crossing-over in eukaryotic organisms. The hypothesis characterized meiosis in terms of three major physiological stages: (1) a presynaptic stage when pairs of homologous DNA stretches are selected so as to become trapped within the synaptinemal complex during synapsis, (2) an alignment of homologous chromosomes and stabilization of paired bivalents via the synaptinemal complex, and (3) a scission and rejoining of DNA stretches leading to the formation of chiasmata and crossovers. The hypothesis centers on the first stage and is based on evidence for the occurrence of significant cytological and biochemical changes prior to synapsis. The major feature of the hypothesis is that crossing-over occurs only in trapped DNA stretches. Thus, potential crossing-over sites, though not crossing-over itself, are determined well before chromosomes pair. Since, to a large degree, crossovers are distributed randomly along the length of each chromosome, the preselection process must result in a random assortment of trapped DNA stretches, the assortment differing from one meiocyte to another.

Chromosomes↗
PubMed1975

Lung cancer.

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Carcinoma, Small Cell↗