A proportional hazards analysis of bone sarcoma rates in German 224radium patients.
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Biomedical subjects
Publications and source records attributed to H Spiess.
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In a patient with Hyper-IgE-syndrome multiple liver abscesses developed in spite of prophylactic treatment with trimethoprim and sulfamethoxazol. Ultrasound confirmed the clinical diagnosis and percutaneous needle aspiration under ultrasonographic guidance and culture of the aspirated pus allowed specific antibiotic treatment by oral chloramphenicol alone without surgical drainage. The isolated Staph.aureus strain was resistant to trimethoprim and sulfamethoxazol.
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Diphtheria and tetanus antibodies were determined in a random sample of 635 test persons of 1 to 25 years of age via the passive haemagglutination test. Using sera and immunoglobulins standardized for protective capacity, titres were expressed as international units (IU). Titres greater than or equal to 0.01 IU/ml diphtheria antitoxin were detected in 96% of children (1-17 years, n = 70), in 79% of adults aged 18-22 (n = 397), in 68% of adults aged 23-25 (n = 168); tetanus antitoxin was found in 96% of children and 90% of adults. 9% of the males between 18 and 22 years of age had no detectable tetanus antibodies before of the same age had no tetanus antibodies. Safe protection (greater than or equal to 0.1 IU/ml) against diphtheria may be expected in 56% of children and in 35% of adults only, against tetanus in 86% and 75%, respectively. 25% of all test persons had excessive tetanus titres (greater than or equal to 10 IU/ml).
CT findings in two related males suffering from the classical X-linked recessive form of Pelizaeus-Merzbacher disease (PMD) are described. CT revealed marked cerebellar atrophy and focal areas of demyelination of cerebral white matter in a 25-year-old patient. This agrees with known neuropathological changes. However, CT was normal in the 14-year-old nephew, although his neurological symptoms were nearly as severe as his uncle's. Judging from this observation and from the scant information in the literature it seems that CT in classical PMD is normal in the first decade and is therefore not helpful in confirming the diagnosis of PMD at an early stage.
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There is no doubt that vaccinations against smallpox, poliomyelitis, measles, German measles and mumps have proved their value. The pocks seem to have been actually eliminated by the WHO eradication program. A vaccination law would seem to be no longer necessary. Poliomyelitis vaccination and those for German measles, measles and mumps should be publicized. Also every child should be given an effective tetanus vaccination three times in the first or second year of life with a booster vaccination at the age of 10 or 12 at the latest. A liquid vaccine (TD) would be desirable as a booster for adults. Up to the 4 year TD and Polio booster vaccinations are recommanded.
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Exostoses are benign cartilaginous tumors of bone. They can occur naturally or be induced by radiation therapy during the time of skeletal growth. We have observed exostoses in 28 of 218 children given repeated injections of radioactive bone-seeking 224Ra. The younger the age at irradiation, the higher the incidence of exostoses. Boys are more susceptible than girls. To our knowledge, none of these radiation-induced exostoses have become malignant, although 36 of these children have developed bone sarcomas elsewhere in the skeleton.
Computerized tomography does not give as fine an information as echography in the presence of intraocular changes, such as retinal detachments, organized vitreous hemorrhages or the differentiation of a choroidal prominence. Complementary computerized tomography, however, can be helpful in the presence of unclear echographic results in opaque media. Furthermore, an analysis of the value of computerized tomography and echography for the evaluation of orbital lesions is presented based mainly on the results of the preoperative tissue diagnosis in 31 histological proven lesions. The results show that a complementary CT-scan is not necessary in orbital lesions of the anterior third when a clear echographic tissue diagnosis exists. In lesions of the middle third of the orbit, echography and CT complement each other. For lesions situated within the orbital apex or for those which are in connection with adjacent structures, such as the intracranial space or the periorbital region, computerized tomography is superior and of a greater help than standardized A-scan echography aided by contact B-scan.
272 cases with visual field defects were examined by CT and analysed. 78 patients showed a chiasmatic lesion, 45 patients a lesion of the optic tract or the lateral geniculate body and 136 patients a lesion of the optic radiation or the occipital cortex. 96% of the CT pictures were topographically corresponding to the known optic field defect. In more then 75% of the operated patients the nature of the CT lesion was confirmed. 10 cases were negative in CT and 3 false positive. Because of the high rate of exact topographic diagnosis CT should be the initial investigation in visual field defects. But the nature of a lesion has to be diagnosed with caution, taking into account the entire clinical picture.