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Biomedical subjects

H Sonobe

Publications and source records attributed to H Sonobe.

At least 145 records · Page 8Linked to original sources
PubMed1988

Postoperative starch granuloma revealed as femoral herniation. A case report.

A rare case of postoperative starch granuloma in a 55-year-old woman, revealed as femoral herniation, is reported. A small, finger-tip-sized tumor showing femoral herniation was noticed 3 weeks after cholecystectomy for cholelithiasis, and no content in the hernia sac was noticed. Histologically, the granuloma situated in the wall of the hernia sac was diagnosed as a starch granuloma consisting of starch granules, which were clearly revealed by polarized light microscopy. These granules were detected in the cytoplasm of macrophages including multinucleated types, some showing a positive immune reaction with antibodies to the alpha-subunit of S-100 protein, vimentin and lysozyme. Starch granules from surgical gloves showed identical features by polarized light microscopy, thus proving the histogenesis of this granuloma. This is the first reported case in the Japanese literature of starch granuloma manifested as femoral herniation.

Cholecystectomy↗
PubMed1988

[A case of juvenile polyp in an elderly person with hepatocellular carcinoma].

A rare case of a juvenile polyp in association with a hepatocellular carcinoma in a 57-year-old male is reported. Both diseases were discovered after admission to hospital because of chronic active hepatitis. A liver biopsy revealed the presence of a trabecular type of differentiated carcinoma. Then, upon colonic fiberscopy, a solitary small pedunculated polyp was detected in the rectosigmoid region. Histologically, the lesion was found to be a typical juvenile one, and composed of cystic dilatations of some glands, including somewhat hyperplastic glands and a wide stroma consisting of chronic inflammatory granulation. The possible histogenesis of this observed polyp in an elderly person also is discussed.

Carcinoma, Hepatocellular↗
PubMed1988

S-100 beta positive T cell leukemia.

We reported a peculiar case with T cell leukemia. The patient was a 34-year-old woman showing extensive splenomegaly and marked leukemic cell proliferation and running a rapid fatal clinical course. The leukemic cells were morphologically ordinary lymphocytes showing suppressor/cytotoxic(s/c) T cell phenotypes and containing S-100b protein. Southern blot analysis revealed rearrangement of the beta chain genes of the T cell receptor (TcR) of the leukemic cells. Because these phenotypic and morphologic features were identical with those of S-100 beta+T lymphocytes (S-100 beta +TL) in normal human peripheral blood, we regarded this case as S-100 beta +T cell leukemia. We discussed clinicopathological features of S-100 beta +T cell leukemia/lymphoma by assessing similar cases reported so far. S-100 beta +T cell leukemia/lymphoma is a new type of s/c T lymphocytic leukemia/lymphoma with aggressive features.

Adult↗
PubMed1988

[Lipoleiomyoma of the uterus--report of a case].

A case of lipoleiomyoma, measuring 4 x 4.5 x 5 cm, in the uterine corpus is reported in a 64-year-old multiparous woman. Histologically, the tumor was mostly composed of mature fatty tissue intermingled with small amount of fibrous and smooth muscle components in an irregularly reticular or clustered pattern. Immunohistochemically fibroblast-like cells around the perivascular areas of the fibrous components were positive in various numbers for S-100 protein, desmin, vimentin, neuron specific enolase, alpha 1-antichymotrypsin and Factor VIII. These results indicated the possibility that the present lipoleiomyoma was derived from multipotential undifferentiated mesenchymal cells, resembling fibroblast-like cells.

Female↗
PubMed1988

[Perianal skin metastasis in a case of lung cancer].

A case of lung cancer in a 78-year-old man who subsequently developed a perianal skin metastasis is herein reported. The metastatic lesion was the fist clinical metastatic sign noticed. Although irradiation therapy reduced the size of the lung tumor, the tumor soon regrew and the patient died of massive hemorrhaging from the perianal mass. An autopsy revealed that the primary tumor and all metastases were, histologically, a mucoepidermoid carcinoma. A metastasis of a lung cancer to the perianal region is extremely rare, only one case involving an anaplastic carcinoma having been previously reported.

Aged↗
PubMed1987

The distribution of alpha and beta subunits of S-100 protein in malignant schwannomas arising from neurofibromatosis of von Recklinghausen's disease.

The immunohistochemical localization of the alpha and beta subunits of S-100 protein in 4 cases of the malignant Schwannomas arising from von Recklinghausen's disease was investigated by the indirect immunoperoxidase method. S-100 alpha-positive cells were few in presumably normal peripheral nerves, moderate in numbers in plexiform neurofibromas and numerous in malignant Schwannomas. In contrast, S-100 beta immunoreactivity, abundantly detected in normal peripheral nerves and plexiform neurofibromas, was completely negative in all of 4 cases of malignant Schwannoma. In addition, double immunostaining method for both subunits revealed their simultaneous existence in cells in the normal nerves and neurofibroma. These results suggest that malignant change of Schwann cells convert their subunit composition of S-100 protein from beta to alpha in these malignant cells. Although the mechanisms for the proportional conversion of the subunits are as yet undetermined, the immunoreactivity of S-100 alpha subunit may be a useful marker for Schwannoma in malignancy.

Adult↗
PubMed1987

Immunocytochemical characterization of S-100 beta-positive human T-lymphocytes by a double immunostaining method.

The antigenic properties of S-100 beta-positive human T-lymphocytes (S-100 beta+ T-cells) were investigated by a double immunostaining technique employing an indirect immunoperoxidase method for cytoplasmic S-100 beta subunit and an immunoalkaline phosphatase method for cell surface antigens detected by various monoclonal antibodies to human lymphocytes. S-100 beta+ T-cells recognized by their diffuse intracytoplasmic immunoperoxidase reaction, also expressed CD2, CD3, CD8 antigens demonstrated by surface blue alkaline phosphatase reactivity, but not CD4, CD1, CD25 (interleukin-2 receptor), or HLA-DR antigens. However, they displayed a blastic change to T-cell mitogens, such as Concanavalin A(Con-A) and PHA, followed by the expression of CD25 and HLA-DR antigens. Under normal conditions, S-100 beta+ T-cells comprised approximately 5-22.8% of CD8+ cells amongst human peripheral blood mononuclear cells.

Animals↗
PubMed1987

Electron microscopic study of mucoepidermoid carcinoma in the pancreas.

An autopsy case of extremely rare mucoepidermoid carcinoma of the pancreas in a 58-year-old male was reported. The main tumor in the pancreatic tail associated with wide-spreading metastases, was histologically composed of squamous cancer cell nests intermingled with mucin-containing cells, but not true glandular structures except for metastatic foci in the liver. Electron microscopic findings of the main tumor revealed roughly three kinds of cancer cells, namely undifferentiated cells, squamous cells, and squamous cells with mucin-containing intracytoplasmic lumina, accompanied by variety of transitional forms. The mucin was similar to that of the intra-or interlobular duct epithelium of pancreas in mucin stains. Immunohistochemically, positive immune reaction of the cancer cells was observed by anti-keratin, -epithelial membrane antigen and -carcinoembryonic antigen sera. These findings suggested that the cancer cells originated from undifferentiated cells of pancreatic duct, which showed multipotency to differentiate predominantly into squamous cells, but also into mucin-producing cells.

Carcinoma↗
PubMed1987

Malignant Brenner tumor with peritoneal metastasis.

A case of malignant Brenner tumor with peritoneal metastasis in a 67-year-old woman was reported. The multilocular cystic tumor of right ovary was 420 g in weight, and their cystic walls were covered with multilayered tumor cells showing papillary pattern very frequently. The tumor was histologically transitional cell carcinoma with occasional glandular structures but no squamous differentiation corresponding to grade 2 or 3 urinary bladder carcinoma. The pattern of benign Brenner tumor was not identified, but there was some area of proliferating Brenner tumor. Immunohistochemically, carcinoembryonic antigen was detected in several tumor cells, especially in the intercellular spaces among them, and cytokeratin was detected only in some tumor cells. Ultrastructurally, the malignant Brenner tumor shared many common features with the benign one and also bladder tumor. Intercellular spaces with microvilli were frequently found and thought to be important for diagnosis. The morphologic criteria of this rare tumor are discussed.

Aged↗
PubMed1987

Multiple carcinoid tumor combined with mucosal carcinoma in the stomach. A case report.

A case of gastric multiple carcinoid tumor combined with mucosal carcinoma in a 63-year-old female is reported. The carcinoid tumors, larger than 0.5 mm in diameter, and endocrine cell micronests, smaller than 0.5 mm in diameter, were mostly located in areas of chronic atrophic gastritis. Their distribution was coincident with that of multiple carcinoid tumor in type A gastritis. The majority of the tumor cells were positive for human chorionic gonadotropin (HCG) and Leu 7 by immunohistochemistry and contained various numbers of intracytoplasmic secretory granules as revealed by electron microscopy. Two mucosal carcinoma foci did not show endocrine characteristics. These carcinoid tumors were thought to have originated in HCG-producing argyrophil cells which had been stimulated by hypergastrinemia accompanying chronic atrophic gastritis. The mucosal carcinomas were regarded as incidental.

Carcinoid Tumor↗
PubMed1987

Combined hepatocellular and cholangiocarcinoma arising in a cirrhotic liver. Report of an autopsy case.

A rare case of combined hepatocellular and cholangiocarcinoma arising in a 56-year-old female is reported. The autopsy disclosed the presence of two different kinds of tumors in the right lobe of the liver, which showed advanced cirrhosis; a massive rubbery, ill-defined and whitish-yellow cholangiocarcinoma and a nodular soft, encapsulated and dark green hepatocellular carcinoma. They were adjacent to each other, but showed no intermingling. Only the massive cholangiocarcinoma had invaded the portal vein and showed several intrahepatic metastatic foci and hepatic, pancreaticoduodenal and perigastric lymph node metastases. Immunohistochemically, carbohydrate antigen 19-9 was strongly positive only for the cholangiocarcinoma component, explaining the high titer of this antigen in the serum on admission. On the basis of these findings, the possible morphogenesis of the tumor observed in the cirrhotic liver is discussed.

Adenoma, Bile Duct↗
PubMed1987

Metaplastic bone formation in a hyperplastic polyp of the stomach: a case report.

Metaplastic bony tissue along with hyperplastic mucosal epithelium showing no atypism was detected in biopsy materials from a Yamada type I gastric polyp. The tissue was metaplastic woven bone associated with calcification. Histogenesis of the bone formation is as yet unknown. This is the first reported case of the presence of metaplastic bone accompanied by hyperplastic gastric mucosa so far.

Aged↗
PubMed1987

[An autopsy case of triple primary cancers consisting of glioblastoma multiforme of the pons, colon cancer and rectal carcinoid--a statistical analysis of cases of brain tumor combined with other primary cancers in Japan autopsy annuals].

An autopsy case of glioblastoma multiforms of the pons with a colon cancer, a rectal carcinoid, a renal adenoma and three gastric leiomyomas in a 81-year-old-woman is reported with a statistical analysis on multiple primary cancers associated with primary brain tumors as reported in the Japan autopsy annuals. Out of 329, 705 autopsy cases from 1975 to 1984 in the Japan autopsy registry, double cancers and triple cancers that included a primary brain tumor amounted to 123 cases (0.037%) and 12 cases (0.0036%), respectively. Other sites for primary cancers were the thyroid (23%), the stomach (15%), the lungs (12%), and the colon (10%) in that order of frequency.

Adenoma↗
PubMed1987

S-100 beta positive human T lymphocytes: their characteristics and behavior under normal and pathologic conditions.

The characteristics of human S-100 beta-positive T lymphocytes (S-100 beta+ T cells) and their fluctuation in peripheral blood under normal and various pathologic conditions were investigated. S-100 beta+ T cells were small lymphocytes with no particular subcellular structures and showed a proliferative response to mitogens. They were present mainly in peripheral blood under normal conditions but accumulated in T zones of lymph nodes with nonspecific T-zone hyperplasia, where numerous interdigitating reticulum cells existed. In healthy adults approximately 1% to 4% (mean 3.4%) of peripheral blood mononuclear cells were S-100 beta+ T cells. The proportion of S-100 beta+ T cells in peripheral blood tended to significantly decrease (less than 0.5%) in patients with neoplastic diseases; this tendency was apparently related to tumor progression.

Adult↗
PubMed1987

[Squamous cell carcinoma and adenosquamous cell carcinoma of the thyroid gland].

Two cases of a squamous cell carcinoma and an adenosquamous cell carcinoma of the thyroid gland are presented. Both cases have survived without recurrence for 18 months and 31 months respectively, although these cases have an unfavorable prognosis. A review of the Japanese literature reveals that these two tumors differ significantly in their clinical features. In cases involving a squamous cell carcinoma the ratio of female to male patients is lower, the duration of the illness before treatment is shorter, and the prognosis is poorer than those with an adenosquamous cell carcinoma. These features suggest that the carcinomas have a different histogenesis.

Adenocarcinoma↗