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Biomedical subjects

H Sone

Publications and source records attributed to H Sone.

At least 145 records · Page 8Linked to original sources
PubMed1984

[Induction of tumor necrosis factor (TNF) by OK-432].

The induction of tumor necrosis factor (TNF) by OK-432 was investigated. The results were as follows: Serum from OK-432 injected into NZW rabbits treated with LPS was cytotoxic to tumor cells in vitro. With respect to the target cell spectrum this factor was cytotoxic to L929, Lewis, M7609 and K562, but not to Chang liver cells, HMV cells or HeLa cells. The cytotoxic activity of this factor was found to be M.W. 48,000 on H.P.L.C., and the pI was revealed to be 5.4 by isoelectric focusing. These results were consistent with previously reported findings on TNF.

Animals↗
PubMed1983

Inhibitory action of 2-(1-,2-benzisoxazol-3-yl)-3-[2-(2-piperidinoethoxy) phenyl]acrylonitrile (SX-284) on acetylcholine release from vagus nerve in guinea pig ileum.

Newly synthesized compound, 2-(1-,2-benzisoxazol-3-yl)-3-[2-(2-piperidinoethoxy)phenyl]acrylonitrile (SX-284) inhibited electrically evoked acetylcholine release from the stores in the myenteric plexus-longitudinal strips of guinea pig ileum which was labelled with [3H]-choline but not the evoked release of tracer from rat vas deferens after labelling with [3H]-norepinephrine. These results support our previous findings that SX-284 specifically inhibit acetylcholine release from the vagus nerve in the gastrointestinal canal.

Acetylcholine↗
PubMed1982

A possible mechanism of a new antispasmodic drug, 2-(1,2-benzisoxazol-3-yl)-3-[2-(2-piperidinoethoxy) phenyl]acrylonitrile (SX-284).

A newly synthesized drug, SX-284, depressed the twitch response of the ileum from guinea pig to electrical stimulation at 0.1 Hz. SX-284 proved to be almost as active as atropine on electrically stimulated ileum. The responses of guinea pig ileum to nicotine and serotonin were also inhibited by SX-284. However, SX-284 did not influence the release of transmitters from the motor, sympathetic, nonadrenergic inhibitory, noncholinergic excitatory nerves, and responses of various smooth muscles mediated through drug receptors, and at these doses, SX-284 inhibited the release of acetylcholine from the vagus nerve. These facts indicate that SX-284 specifically inhibits the acetylcholine release from the vagus nerve. Furthermore, spontaneous movement of the guinea pig ileum was dose-dependently depressed by SX-284. The potency ratio for SX-284 relative to atropine was 1.7.

Animals↗
PubMed1981

Cytologic characteristics of oat-cell carcinoma of the lung in relation to the effect of chemotherapy.

The cytologic study of the effect of chemotherapy was performed in oat-cell carcinoma of the lung. Cellular characteristics of tumor cells obtained by brushing via bronchoscopy were compared between responders (13 patients in complete and partial regressions) and nonresponders (13 patients with no response) treated with cyclophosphamide. The tumor cells in the responders more frequently showed finely granular chromatin evenly distributed throughout the nuclei. The tumor cells in nonresponders showed predominantly either deeply stained nuclei with coarsely granular chromatin distributed evenly or pale nuclei with unevenly distributed chromatin. These findings were also applied in the evaluation of the effect of combination chemotherapy. The nuclear chromatin pattern from oat-cell carcinoma of the lung may be an indicator to predict the degree of response to chemotherapy.

Aged↗
PubMed1979

[On renal excretion of sodium 4-iodo-5-methylpyrazole-3-carboxylate-131I (author's transl)].

Sodium 4-iodo-5-methylpyrazole-3-carboxylate-131I(IMPC-131I) was synthesized by isotope exchange with Na 131I in the molten state to evaluate its potential usefulness as a renal function and/or imaging agent. Tissue distribution and clearance characteristics of IMPC-131I are described. Tissue distribution experiments in rats indicated a very high renal concentration of radioactivity following intravenous administration. At 5 min the kidney took up 27.8% of the injected dose (16.1% dose per gram) and the total activity in the kidney still accounted for 9.8% of the injected dose at 30 min, with only 1.2% localizing in the liver. The ratios for kidney-to-liver in the concentration of IMPC-131I were always higher than those of hippuran -131I throughout the period of the experiment. Within 24 hr, 78.6% of the injected dose were excreted in the urine. The autoradiographic and the scannographic studies were also performed. The present results suggest that IMPC-131I has potential as a new agent for both funciton and imaging studies of the kidney.

Animals↗
PubMed1978

Studies on drug metabolism by use of isotopes. 23. Metabolic study of 1-butyryl-4-cinnamylpiperazine in the rat during development of tolerance by using two kinds of deuterium-labeled forms.

Mass fragmentographic determination of the plasma, brain, and liver levels of 1-butyryl-4-cinnamylpiperazine (I) and its metabolites in tolerant and nontolerant rats was carried out by using two kinds of deuterium-labeled compounds. 1-Butyryl-4-[a-d2]cinnamylpiperazine (I-d2) was used to develop tolerance and 1-butyryl-4-[arom-d5]cinnamylpiperazine (I-d5) to clarify the metabolic fate of I after I-d2 administration. The present method allowed the clarification of the metabolism of I-d2 and I-d5 independently. In tolerant rats, the brain and liver were lower for I-d5 and higher for I-d5 metabolites than in nontolerant rats. There was no significant difference in the plasma levels of I-D5 between tolerant and nontolerant rats. Our data seem to suggest that development of tolerance to I results from a more rapid metabolism of the drug due to hepatic enzyme induction.

Animals↗