[Current status of the therapy of malignant testicular tumors].
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Biomedical subjects
Publications and source records attributed to H Sommerkamp.
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Incidence, extent, and time of seed loss after retropubic I-125 implantation was assessed in 52 patients treated for prostatic carcinoma. Radiographic controls up to 62 months were done to evaluate losses. Ninety percent of all patients lost seeds, averaging 8% of total implant number. Loss most frequently occurred within the first month by transurethral routes. Monitoring for seed loss is mandatory to assess dose deficit or inhomogeneous dose distribution, and to avoid environmental radiation hazards.
Clinical followup of 52 patients treated with I-125 implants for localized prostatic cancer demonstrated local control in 85% and failure in 15%. Determining factors for local control or failure were analyzed and underline that homogeneous dose distribution is the most important factor for local control in interstitial radiotherapy. With the use of I-125 seeds this can only be achieved in small-volume (T2) stages with refined technique. For larger tumor volumes (T3) an external boost or the use of other radionuclides is preferable.
A case of leiomyoma of the bladder in a 37-year-old man is described. Clinical features and findings on excretory urography resembled a malignant tumor of the small pelvis. Ultrasound, computed tomography, and angiography nevertheless made the correct preoperative diagnosis. Special emphasis is given to the differentiation between benign and malignant smooth muscle neoplasms.
Pelvic lymphadenectomy and interstitial radiotherapy of the prostate for early carcinoma is a procedure with a significant postoperative morbidity, depending on the extent of dissection, type of drainage, and use of heparin. Hematoma and lymphocele formation seem to be promoted by heparin. Limited lymph node dissection, appropriate drainage, and the abandonment of heparin for prophylaxis of thromboembolism can reduce the complications associated with pelvic lymphadenectomy.
Open renal surgery for calculous disease replaced by percutaneous and shock-wave methods. Oncology: Modified lymphadenectomy for testicular tumors and initial chemotherapy for stage III seminoma; potency preserving treatment of early prostatic cancer by modified surgery or interstitial implants. GNRH-analogues for pharmacological castration: conservative attitude towards renal and urethral trauma. Prostheses for urinary incontinence and impotence.
Indications for preoperative and palliative embolization of renal tumors have been restricted due to the failures caused by insufficient tumor blockage. Personal experiences using a variety of materials (balloon n = 18, gelfoam n = 10, ethibloc1 /glucose n = 23) and their effectiveness are presented. special emphasis is placed on the influence of parasitic collaterals and the complication rate on the various procedures. Clinical results corroborate those obtained from our own animal experiments: only a capillary embolization that is based on the tumor volume exhausts the current possibilities of therapeutic vascular occlusion of tumors.
The fundamental disorder in renal tubular acidosis--the impaired excretions of hydrogen ions--can favourably be influenced by etacrynic acid (Hydromedin). Net acid and calcium excretion was measured in eight patients with incomplete RTA I and five controls before and during treatment with the diuretic: urinary pH was lowered and net acid excretion increased (p less than 0.05) with only slight rise in urinary calcium. Etacrynic acid appears to be particularly suitable for the long term treatment of patients with incomplete RTA I and calculous disease.
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In renal disease, therapeutic procedures performed by radiologists include embolisation, cystography with obliteration and percutaneous nephrostomy. More than 72 therapeutic occlusions of the renal artery by balloon, coil, and gelfoam are presented. Basic differences in technique of application and in the mechanism of Ethibloc in comparison to other kinds of embolisation material are pointed out. In 61 diagnostic punctures of renal cysts, guided by sonograpny, 31 were treated by injection of Lipiodol. As in cystography, the combination of sonography and radiology proved to be highly valuable in 37 percutaneous nephrostomies. Technique, indication, contraindication, and complication of renal embolisation, renal cystography and percutaneous nephrostomy are briefly discussed.
The practical and organizing performance of interstitial radiation therapy with 125-I-seeds in prostatic carcinoma is reported. Precautions and measurements for radioprotection are emphasized. First evaluations of these measurements show that this therapeutical technique can be performed in complete accordance with the directive for radioprotection. The computer-assisted isodose-planning and the in-vivo-measurements in the rectum, urethra and bladder confirm the steep decrease of the dose outside the irradiated focal volume. Hence, inflammatory symptoms accompanying the therapy are markedly allayed in comparison with percutaneous radiation therapy, in spite of a higher tumor dose. Because of the extensive operation, attention must be paid to the strict observation of indication criteria.
The antimicrobial efficacy, general and local tolerance of a new intramuscular application form of trimethoprim/sulfamethoxazole was evaluated in a French-German clinical study. Fifty-five urological patients with urinary tract infections were treated with two i. m. injections (3 ml) daily over three to five days followed by oral medication. The study revealed excellent antimicrobial efficacy of the drug. In general TMP/SMZ was tolerated well after i. m. administration. Elevation of creatinine phosphokinase was observed in only three patients treated i. m. for five days. The high viscosity of the solution renders i. m. injection technically difficult, leading to a high proportion of local complications. The indications for use of i. m. administered TMP/SMZ in the hospital are limited, however it should be suitable for private practitioners in that an effective antimicrobial treatment can be started which can be continued by oral or intravenous medication.
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First experiences concerning reconstructive vascular surgery in malignant tumor surgery are presented. In order to improve total tumor excision, the resection of great veins or nutritive arteries may become necessary. In some cases the reconstruction of vascular defects together with tumor resection may be indicated. Only in the case of younger patients vascular reconstruction of essential vessels seems to be indicated.
90 diagnostic exposures of the testis for confirming the clinical diagnosis of a malignant testicular tumor were examined. Wherease in 45 cases the diagnosis was confirmed, in the other 45 cases various diagnoses were established. Macroscopic examination only lead to a high incidence of false diagnoses (15%) followed by unnecessary orchiectomies. Thus, whenever possible a histological confirmation of the macroscopic findings should be made by frozen section before performing orchiectomy.
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