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Biomedical subjects

H Sommer

Publications and source records attributed to H Sommer.

At least 145 records · Page 8Linked to original sources
PubMed1982

[Effect of the nitrogen components of a peptide diet and the analogous amino acids on pancreatic secretion in the human].

In healthy volunteers (n = 10), the exocrine pancreatic secretion was studied after intragastric administration of a peptid solution which corresponded to the nitrogen component of a commercially available peptid diet, and of a solution of the analogous amino acids. Both test solutions were emptied out of the stomach in the same time interval and evoked a comparably high pancreatic secretion of volume, amylase, lipase, trypsin and chymotrypsin. These findings are discussed in regard to recommendations to apply elemental diets for treatment of complicated pancreatitis.

Acute Disease↗
PubMed1982

[Psychic guidance and sexual rehabilitation of patients with genital malignoma].

Reported are results obtained from systematic interviews with 250 tumour after-care patients at the Gynaecological Hospital of Jena University. Information was gathered on psychic and sexual problems, and conclusions were drawn for medical practice, with particular reference being made to enlightenment on the disease and to sexual rehabilitation. It is the established intention of all people involved in treatment and after-care to counteract by active therapy-accompanying spiritual influence psychic disbehaviour caused by the disease. Efforts to build up optimistic attitudes are intended to produce favourable effects upon all phases of the disease.

Adaptation, Psychological↗
PubMed1981

Transposon Tn951 (TnLac) is defective and related to Tn3.

Tn951 is flanked by two perfect inverted repeats of 41 bp which include the 38 bp sequence of the IR of Tn3. Tn951 also contains the last 100 bp of the tnpA gene but with at least two mutations. However, beyond nucleotide 137 the sequences diverge and hybridization experiments show that Tn951 lacks at least the first two thirds of the tnpA gene. In agreement with these observations Tn951 does not transpose by itself at a detectable frequency but can be complemented by the tnpA gene of Tn801 or Tn3. Tn501, Tn1721 and gamma delta do not complement Tn951 transposition. Transposition of Tn951 duplicates 5 bp of target DNA sequence.

Base Sequence↗
PubMed1981

A new type of IS1-mediated deletion.

Genetical tests and DNA sequence analysis revealed that the mechanism of formation of IS1-induced type I and type II deletions differs. IS1-mediated type II deletions occur at the termini of the integrated element and do not remove the element. This process is independent of the cellular recA system and does not involve DNA sequence homology. Conversely, the formation of IS1-induced type I deletions differs substantially. They require recA gene product, small DNA sequence duplications and a topological arrangement of the DNA molecule to allow alignment of duplications.

Base Sequence↗
PubMed1981

Effect of acetylcholine, gastrin, and glucagon alone and in combination with secretin and cholecystokinin on the secretion of the isolated perfused rat pancreas.

Dose-response curves of acetylcholine (ACh), gastrin, and glucagon given alone or in combination with a submaximal dose of secretin (S;' 5.0 U/h) plus cholecystokinin (CCK; 1.0 U/h) were studied in the isolated perfused rat pancreas. ACh (25 x 10-9 mol/h) increased the basal secretory flow ( mean +/- SEM: 1.19 +/- 0.22 microliter/min) by 693% and protein output (2.7 +/- 0.2 microgram/min) by 1726%. The protein secretion evoked by S plus CCK was further increased by ACh to a maximum of 26% whereas the volume secretion remained unaltered. Gastrin (100 ng/h) stimulated the protein output by 352% and, when combined with S and CCK, up to further 23% and the secretory flow by 37%. Glucagon evoked a significant (P less than 0.005) increase of the protein output, but decreased the volume as well as the protein output (by 43% and 32%, respectively; P less than 0.05) when it was combined with the tested doses of S and CCK.

Acetylcholine↗
PubMed1981

Dietary effects on pancreatic exocrine function. Experiments on the isolated perfused rat pancreas.

Studies of the response of the isolated perfused rat pancreas to three doses of secretin (5.0, 10.0, 18.75 U/h) and CCK (0.6, 1.5, 2.4 U/h) show that a 35-day administration of a carbohydrate-rich (60% carbohydrate, 3% fat, 20% protein) or fat-rich (34% fat, 11.3% carbohydrate, 29.8% protein) diet increases the sensitivity of the gland to these hormones compared to a standard diet (50.5% carbohydrate, 4% fat, 19% protein). The maximal secretory flow on stimulation by secretin and on a combined stimulation by secretin (2.5 U/h) plus CCK (1.8 U/h) is significantly (p less than 0.05 and p less than 0.01, respectively) lower in both experimental diets than in controls, whereas the maximal protein and enzyme secretion is diminished only in the secretin plus CCK-stimulated pancreas of rats fed a fat-rich diet. A carbohydrate-rich diet results in a relative increase in amylase secretion and decrease in lipase and chymotrypsinogen output. Compared to controls, the fat-rich diet leads to a stronger secretion of lipase and chymotrypsinogen and to a reduced amylase secretion. This adaptation of the exocrine pancreatic function is rather due to changes in the organ itself than to an altered hormonal stimulation.

Amylases↗
PubMed1981

The action of synthetic secretin, cholecystokinin-octapeptide and combinations of these hormones on the secretion of the isolated perfused rat pancreas.

Determinations of dose-response curves for synthetic secretin and for the octapeptide of cholecystokinin (CCK-8) in the isolated perfused rat pancreas reveal that both secretin and CCK stimulate the pancreatic secretory flow and enzyme secretion. The maximal secretory flow evoked by CCK-8 (1.75 +/- 0.24 microliter/min) equals that evoked by secretin, while the protein output (57.1 +/- 6.3 microgram/min) is approximately twice as high. Stimulation by secretin combined with CCK-8 results in summation of the hydrokinetic action and potentiation of the ecbolic action of these hormones. Since the secretory parameters decrease by supramaximal stimulation, the dose-response curves are biphasic. The secretion of pancreatic enzymes correlates significantly (p less than 0.0005) with the protein output. However, the ratio of amylase, lipase and chymotrypsinogen to protein depends on the degree of pancreatic stimulation in so far as amylase secretion increases significantly (p less than 0.01) more markedly than that of both other enzymes.

Amylases↗
PubMed1981

[The problem of accidental paravenous application of cytostatics--case history (author's transl)].

Growing importance is being gained by cytostatic substances and their therapeutic use on genital malignomas, in particular ovarian carcinoma. Increasing use of cytostatics, which are all characterised by extremely low therapeutic index values, has aggravated the risk of undesired side-effects, including toxic phenomena.--Reported in this paper is the case history of a patient who had suffered irreversible damage due to tissue necrosis of one forearm. Reference is made to possible approaches to prophylaxis for the purpose of preventing occurrence of localised side-effects of chemotherapy for neoplasias.

Antineoplastic Agents↗
PubMed1980

The effect of dietary fiber on the pancreatic excretory function.

The effects of dietary fiber on the pancreatic exocrine function was studied in volunteers using the Lundh test. Since only limited information can be derived from this test, additional studies were carried out in rats. In man, the duodenal content aspirated for 90 min. after administration of a test diet supplemented with pectin or carob-bean flour, was significantly (alpha less than 0.01) lower than in a control test (n = 10). In the animal experiment, the volume secretion of the pancreas was also decreased after carrageenan and guar, which were studied in addition (each n = 10; alpha less than 0.025). The protein and enzyme output showed a slight reduction, but this was statistically significant in only some of the cases. An influence of the viscocity, osmolarity and pH-value of the test diets was ruled out as a potential cause for the observed alterations in the pancreatic exocrine function.

Adult↗