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Biomedical subjects

H Snyder

Publications and source records attributed to H Snyder.

25 records · Page 2Linked to original sources
PubMed1981

Urodynamic evaluation of prostatic enlargements with micturitional vesicourethral static pressure profiles.

We studied 58 men with prostatism, who were between 58 and 75 years old, with micturitional vesicourethral static pressure profiles. The study consisted of recording static (lateral) pressures of successive segments of the posterior urethra during voiding, with synchronous monitoring of the vesical pressure activity. An abnormal pressure decrease across the supramontane urethra was considered to be a functional compromise to the prostatic urethra. The studies indicated that the degree of prostatic urethral obstruction was not related to the clinical and endoscopic assessment of prostatic enlargement. Three major patterns emerged from our studies: 1) moderate to severe prostatic enlargement with severe obstruction, 2) moderate to severe prostatic enlargement with minimal or no obstruction and 3) minimal prostatic enlargement with severe obstruction. Also, a good correlation became apparent between micturitional vesicourethral static pressure profilometry and uroflowmetry.

Aged↗
PubMed1976

Anterior detrusor tube repair for urinary incontinence in children.

The technique, complications and results of an anterior detrusor tube repair for urinary incontinence in children is described. It appears that this procedure is appropriate only for selected cases of urinary incontinence but that it is an operation which should be within the paediatric urologist's repertoire. It is simple to perform, but care should be taken, by omental packing, to prevent a sharp posterior lip to the newly formed bladder neck.

Child↗
PubMedDate not supplied

Accuracy of blood ethanol determination using serum osmolality.

A retrospective review of 81 emergency department patients was performed to determine the accuracy of blood ethanol levels (BEL) calculated from serum osmolality. The osmolar gap (measured-calculated serum osmolality) was used to determine the calculated BEL. The mean difference between calculated and measured BEL was 49.2 mg/dL. Calculated BEL overestimated measured BEL in 83% of patients. Adding a correction factor for unmeasured osmoles to the equation for calculated serum osmolality will reduce this error.

Alcoholic Intoxication↗
PubMedDate not supplied

Signs and symptoms of patients with brain tumors presenting to the emergency department.

This retrospective chart review was conducted to determine the presenting signs and symptoms of patients with primary brain tumors diagnosed in the emergency department. There were 101 patients (65 males and 36 females) identified with a hospital discharge diagnosis of primary brain tumor who were admitted through the emergency department. The presenting symptoms included headache (56 patients), altered mental status (51 patients), ataxia (41 patients), nausea or vomiting (37 patients), weakness (27 patients), speech deficits (21 patients), and sensory abnormalities (18 patients). The presenting signs included motor weakness (37 patients), ataxia (37 patients), papilledema (28 patients), cranial nerve palsies (26 patients), visual deficits (20 patients), and speech deficits (12 patients). The average age was 42.8 years, with a range of 3 days to 88 years. The majority of tumors were malignant astrocytomas. Tumor location was cortical in 68 patients, subcortical in 9 patients, and brainstem or cerebellum in 24 patients. In conclusion, patients of all ages may present to the emergency department with a variety of symptoms resulting from a primary brain tumor. Headache and altered mental status were common in our series of patients, but symptoms will depend on the size, location, and type of tumor. A complete neurologic examination is essential, including evaluation for papilledema.

Adolescent↗
PubMedDate not supplied

Serum and urine concentrations of flunitrazepam and metabolites, after a single oral dose, by immunoassay and GC-MS.

A clinical study was conducted to assess the ability of commercially available immunoassays to detect flunitrazepam (FNP) in plasma and urine samples and to compare the results with those obtained by gas chromatography-mass spectrometry (GC-MS). The clinical study consisted of four individuals (two male and two female) who had taken a single 2-mg dose of FNP. Serum was collected over a 48-h period and urine was collected over a 72-h period. The serum and urine samples were analyzed by the COBAS INTEGRA Serum Benzodiazepines assay (SBENZ), the TDx serum and urine Benzodiazepines assay, and GC-MS. The GC-MS procedure was developed for analysis of FNP and metabolites in plasma and urine using an acid hydrolysis step resulting in the formation of specific benzophenones corresponding to FNP and its metabolites. The relative sensitivities of the assays for the detection of FNP and metabolites in serum and urine were GC-MS > SBENZ > TDx. The immunoassay results for serum samples showed peak concentrations of FNP metabolites at 8 h after FNP ingestion for three individuals and at about 1 h for the fourth individual. The GC-MS, SBENZ, and TDx urine immunoassays detected drug above the stated limit of detection (LOD) in 44, 41, and 35 serial FNP urine samples, respectively. FNP metabolites were detected in urine samples with all three assays for up to 72 h after a 2-mg dose. The improved detection rate with the SBENZ assay as compared to the TDx assay is likely explained by its higher cross-reactivity with the major metabolite, 7-amino-flunitrazepam (7-amino-FNP), and its lower LOD.

Administration, Oral↗