[Education--The basis is in order].
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Biomedical subjects
Publications and source records attributed to H Sloth.
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Seventy-two operations for abdominal aortic aneurysm (AAA), i.e 104 per mill. per year, were carried out by a vascular surgical unit integrated into a general surgical department. Mortality rate for elective operation was 3.8%, for acute operation without rupture 3.8% and with rupture 31.6%. Fifty percent of patients with rupture reached operation, which gives an overall mortality of about 66% and an incidence of 56 per mill. per year. Twice as many acute operations were carried out in this area compared to the rest of Denmark, and no haemodialysis-demanding complications occurred. These observations suggest that short transfer time is an important prognostic factor when treating ruptured AAA.
A questionnaire investigation was undertaken to compare the employment of alternative treatment in patients with irritable colon (CI) and ulcerative colitis (CU) as compared with a control group of appendectomized (A). A total of 430 questionnaires were sent out. The percentage of replies was 83 without significant difference between the patient groups. Alternative therapists were consulted more frequently by the CI group than the two other groups which did not differ from one another in this respect. Both CI and CU had employed "natural medicine" more frequently than the control group. Women and younger patients were the most frequent employers of the alternative system. The effect of alternative treatment was frequently experienced in the form of headache and discomfort in the locomotor system. The average expense of treatment was 1,000 Danish crowns (approximately 83 pounds). 23% of the CU group and 41% of the CI group experienced aggravated or unchanged abdominal symptoms compared with their complaints during the period of hospitalization 1-10 years prior to the current investigation. No correlation could be demonstrated between a favourable course and employment of the alternative system.
Adenomyomatosis of the gall bladder is a condition of benign hyperplasia of unknown etiology. Characteristic of the condition is local or diffuse thickening of the muscular layer with invagination of the epithelium forming the so-called Rokitansky-Aschoff's sinus. The prevalence is unknown. In a prospective autopsy material, localized adenomyomatosis, adenomyoma, was found in 7%. This is considered to be the lowest value for the prevalence in the older age groups. Cholecystography and cholecystectomy materials show varying frequencies of adenomyomatosis, 2-33%. There is no definite proof that adenomyomatosis is a symptom-producing condition but several studies suggest that it may be and that in selected cases it may be treated by cholecystectomy. Selection depends upon the duration and severity of the symptoms. Routine diagnosis may be made with the aid of ultrasonic scanning. In more obscure cases with symptoms from the biliary tract, oral cholecystegraphy may be recommended possibly including exposures after a meal rich in fats or after administration of cholecystokinine.
In a prospective study, the clinicopathological effect of prednisolone was evaluated in six patients with collagenous colitis. Prednisolone was associated with a significant decrease in stool frequency. However, the effect was transitory, since the diarrhoea recurred when prednisolone treatment was discontinued. There was a trend toward a diminished inflammatory response in the post-treatment biopsies, but the thickness of the collagen band remained unchanged, except in one patient. Until the results of further studies are available, we recommend that treatment with prednisolone be restricted to periods of acute diarrhoeal episodes.
A 13-year departmental sample of 34 patients with definite (biopsy-verified) giant cell arteritis (GCA) was reviewed. The mortality of this material was compared to sex-, age- and time-specific death rates in the Danish population. The standardized mortality ratio (SMR) was 1.8 (95% confidence limits, 1.1-2.8). During the same period 146 patients with probable (not biopsied, but clinically diagnosed in the department) GCA and 85 cases of possible (diagnosed and treated before admission) GCA had been admitted to the department. Those two groups did not differ from the biopsy-verified group with respect to SMR, sex distribution or age. In the group of patients with department-diagnosed GCA (definite + probable = 180 patients), the 95% confidence interval for the SMR of the women included 1.0. In all other subgroups there was a significant excess mortality. Excess mortality has been found in two of seven previous studies on survival in GCA. The prevailing opinion that steroid-treated GCA does not affect the life expectancy of patients is probably not correct.
In a material consisting of 194 patient with arthrosis of the hip joint, waiting for alloplastic operation, the incidence of alternative treatment and the pattern of this was investigated. 43% had been treated by alternative methods. Eighty-eight per cent had sought alternative treatment because of hip pain. No differences in user frequency and pattern were found in Odense and Holstebro. The use of alternative treatment was unrelated to the duration of pain, pain intensity, sex and age.
Few objective measures exist to predict the outcome of ear surgery. Clinical and experimental experience has shown the key role of the Eustachian tube in this respect, but clinical testing is seldom performed. The present study confirms that Eustachian tube testing may be of clinical significance by comparing preoperative test results before myringoplasty with the late results of this operation. In 157 patients the ability to equilibrate a static air pressure of plus or minus 200 mm of water passively or actively was tested. It turned out that in those 15% who could equilibrate minus 200 mm passively a 7 times higher rate of successful myringoplasty was found. Ears with cholesteatoma showed less ability to equilibrate actively. Despite these findings it is concluded that the present tests are insufficient for clinical use.
A group of outpatients with chronic non-organic upper abdominal pain was followed up 5-7 years after the index investigation, to evaluate the predictive value of several variables on the basis of a questionnaire and a laboratory pain study. Fifty-four per cent had symptoms of irritable bowel syndrome. A low pain tolerance measured with an ischemic pain technique significantly predicted a poor course of the disease (P = 0.03). So did a high score indicating psychic vulnerability (P = 0.02) and two social factors: poor school and vocational education (P less than 0.01). Without significant predictive value were level of abdominal pain rated on a visual analogue scale, length of dyspepsia history, bowel habits, relation of pain to meals and to life events, heartburn, headache, back pain, dysmenorrhea, paresthesias in fingers or feet, present occupation, sex, marital status, days absent from work because of the disease, and consumption of tranquilizers, cigarettes, and alcohol. The findings indicate that psychologic factors and a low pain tolerance may be elements in this poorly understood syndrome. This is supported by earlier findings of a decreased pain tolerance and an elevated psychologic score in this group compared with controls.
A case is presented of an isolated aneurysm of the internal iliac artery in a patient with signs of lumbar disc herniation. Isolated aneurysms of the internal iliac artery are rare and they may present with symptoms of compression of adjacent structures or hemorrhage.
To establish the diagnostic safety and the prognosis in outpatients with non-organic upper abdominal pain, 37 patients were followed up 5-7 years after the index investigation. In only one case had the diagnosis been changed during the follow-up period. This was in a man who erroneously had not been examined sufficiently before entry. He turned out to have gallstones. Eighty-one per cent still had abdominal pain, but 51% had improved (P less than 0.005). At the index investigation back pain was reported by 76% and headache by 60%. At the follow-up study back pain was unchanged in severity, but headache was significantly improved. The course of abdominal pain was significantly correlated with the course of back pain and headache. At the index investigation a psychic symptom score indicating vulnerability was significantly higher than in a matched patient group with well-defined pain. It was unchanged high at the follow-up study and unrelated to the course of the abdominal pain. Fifty-four per cent of the patients had symptoms of irritable bowel syndrome, but the course of the abdominal pain was unrelated to this.
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