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Biomedical subjects

H Siwiec

Publications and source records attributed to H Siwiec.

At least 19 recordsLinked to original sources
PubMed2001

[Detection of human papillomavirus type 16 and 18 in laryngeal cancer using PCR methods].

Human papillomavirus (HPV) is a small DNA virus. HPV is can be divided into two groups: mucosal and cutaneous. HPV have various oncogenic potential. The correlation between presence of high oncogenic type of HPV and carcinogenesis was confirmed in human anogenital tract and cervical carcinoma. The latest studies suggest HPV infection involvement in benign and malignant lesions of aerodigestive tract. The aim of our study was to determine the presence of the HPV genes E6/E7. The specimens were taken after total laryngectomy from 20 patients with squamous cell carcinoma. The fresh tissue specimens were frozen at -70 degrees C until DNA extraction and HPV detection. The presence of HPV DNA was assessed by polymerase chain reaction using specific primers for HPV 16 and 18 E6/E7. There were 7 (35%) HPV positive specimens in our group. 5 (25%) specimens were HPV 16 positive, 4 (20%) specimens were HPV-18 positive. In two cases HPV 16 and HPV 18 was present. The results suggest that high oncogenic types of HPV may play a role in pathogenesis of laryngeal carcinoma.

Adult↗
PubMed2001

[Epistaxis: causes and management].

Evaluation of 265 patients treated in hospital due to nasal bleeding revealed that almost half of them suffered from hypertension and in about 30% of cases it was impossible to establish the cause of epistaxis. The most frequent way to stop the bleeding was anterior nasal packing and in case of failure posterior nasal packing together with anterior one. Posterior nasal packing with Foley's catheter is relatively simple and effective procedure. Introduction of superselective embolization of maxillary artery and dermoplasty in Rendu-Osler disease was very helpful.

Adolescent↗
PubMed2001

[Melanoma of nasal cavity and paranasal sinus mucosa].

In a group of 15 patients with malignant melanoma of the nasal cavity and paranasal sinuses the place of origin was nasal mucosa in 11 patients, the ethmoid cells in 2 cases and the maxillary sinus in 2 cases. Only 5 patients had tumour limited to infrastructure of the nasomaxillary complex, in 10 patients tumour occupied also suprastructure. Total maxillectomy was performed in 4 patients, partial maxillectomy in 8 patients with orbital exenteration in 3 patients. Of 12 patients operated on three patients died one year, two patients two years and one patient 6 years after surgery. One patient is alive 12 years, three patients are alive three years and one patient is alive one year after surgery.

Adult↗
PubMed2001

[Free forearm skin flap with microvascular anastomosis for oral cavity reconstruction].

Free forearm skin-fascia flap was used in 8 patients for intraoral reconstruction. Tissue defect was located in anterior part of the oral cavity in three patients and in lateral part in 5 patients. In the first three patients microvascular anastomosis was performed first and the flap was sutured in the oral cavity later on. In one of these patients the whole flap and in two patients about half of the flap necrotised. In the next 5 patients oral defect was closed first and then microanastomosis was done with good result in all the patients. We advise the last type of reconstruction. Free forearm skin-fascia flap provides good anatomical and functional result of reconstruction in the oral cavity.

Adult↗
PubMed2001

Short- and long-term results of stapedectomy in children.

Otosclerosis in children and teenagers is very uncommon. Typical otosclerosis presents as a slowly progressive conductive hearing loss and tinnitus in the third to fourth decade of life. Stapedectomy is a well-established procedure for correction of conductive hearing loss in adult patients with otosclerosis. The aim of this work is to assess short- (6 months) and long-term (7 years) results after stapedectomy performed in 10 patients under 20 years of age. In 1 patient cochlear otosclerosis was diagnosed and in 1 patient incus anomaly was found during the operation. Pure tone audiograms obtained 6 months after stapedectomy showed air-bone gap closure to 10 dB in 6 patients, to 15 dB in 8 patients and in all patients to 20 dB. Average air conduction threshold improved by 26.5 dB and average bone conduction threshold by 5.9 dB. 7 years after stapedectomy air-bone gap was similar to the one measured 6 months postoperatively. Stapedectomy in children provides good and stable hearing results.

Adolescent↗
PubMed2000

[Pharyngeal closure after pharyngolaryngectomy].

Pharyngolaryngectomy was performed in 53 patients. In 36 patients pharynx defect was less than 50% of pharynx circumference and it was closed without reconstruction. Larger pharynx defects were closed using platysma myocutaneous flap (13 cases), pectoralis mayor flap (3 cases) and free forearm flap with microvascular anastomosis (1 case). Healing results are presented in each group of patients.

Adult↗
PubMed2000

[Expression of Bcl-2 antigen in laryngeal carcinoma].

The results of immunohistochemical investigations of BCL-2 presence in 50 patients with laryngeal carcinoma were presented. In 14% of all investigated cases presence of BCL-2 protein was observed. In patients with advanced clinical stage of laryngeal carcinoma higher expression of BCL-2 protein comparing with patients with lower clinical stages was more frequently observed--but it wasn't significant. No significant difference in presence of BCL-2 protein among the patients with a different stage of histological differentiation of carcinoma and among the patients with present and absent metastatic changes in regional lymph nodes was observed.

Adult↗
PubMed1995

[Diagnosis of temporal bone paraganglioma].

On the basis of 7 cases of temporal bone paraganglioma diagnosis of this tumor is presented. Apart from aural symptoms cranial nerves palsy may appear. Computer tomography, magnetic resonance imaging and subtraction angiography are essential investigations.

Adolescent↗
PubMed1995

[Face deformation and function defects after maxillectomy].

In the group of 42 patients after maxillectomy face deformation and function defects were assessed. The best cosmetic and functional result was observed after maxillectomy without orbital exenteration, with preservation of lateral part of the zygomatic bone and at least a half of nasal skeleton. Severe face deformation developed after orbital exenteration, resection of the palpebrae, cheek and external nose.

Adolescent↗
PubMed1994

[Platysma myocutaneous flap in intraoral reconstruction].

Plastyma myocutaneous island flap was used in 13 patients to reconstruct tissue defect after oral cancer surgery. Necrosis of the skin island in the oral cavity occurred in 3 patients. A fistula developed in one patient with a large defect of the tongue, pharynx and mandible. In 12 patients wound healing on the neck was good. Plastyma myocutaneous flap is very useful to close defects of the floor of the mouth and up to the half of the tongue width.

Adult↗
PubMed1991

[Degree of utilization of hearing aids by adults].

The amount of use of hearing aids was assessed in 190 adults and 22.6% of them used the aid always, 23.7% most of the day, 22.6% every day a little, 20.0% sometimes and 11.1% never. The hearing aids were used more by patients with profound hearing loss than by patients with moderate loss and more by younger and working subjects than by elderly and non-working ones.

Adult↗
PubMed1989

Problems of the hearing impaired in Poland.

Auditory disability was studied in a group of 140 Polish hearing aid candidates using an oral presentation of the problem questionnaire of Barcham and Stephens (1980). The overall pattern of problems reported by Polish hearing-impaired patients was similar to that found among English respondents. Some difference in the prevalence of the problems emerged which may result from the different socio-economic situations in the two countries.

Adolescent↗
PubMed1989

Serum iron and total iron binding capacity in larynx cancer patients treated with surgery.

A decrease in serum iron and total iron binding capacity (TIBC) has been seen in patients with various malignancies. Similar iron level and TIBC alterations we have found in patients with larynx cancer. Estimation of TIBC reflects the quantity of transferrin which is the iron carrier in serum. The serum iron and transferrin changes cannot be used for diagnostic purposes because they are not specific to malignancies. Such alterations have been also seen in inflammatory and infectious diseases, heart infarct and anaemias. However, it is of interest whether elimination of neoplastic tissue from an organism brings back the decreased serum iron and TIBC to normal values.

Adult↗
PubMed1988

Self-reported benefits of hearing aids by the hearing impaired.

Benefits of hearing aids were studied in a group of 169 patients using an open-ended self-report approach. The overall pattern of benefits was qualitatively similar to the pattern of complaints reported by candidates for hearing aids (Golabek et al., 1988). The response pattern was related to the age and work of the hearing aid users, to the level of the hearing loss in the better ear and to the amount of use of the hearing aid.

Adolescent↗