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Biomedical subjects

H Sinclair

Publications and source records attributed to H Sinclair.

At least 19 recordsLinked to original sources

Agalactosyl IgG: an aid to differential diagnosis in early synovitis.

Sixty consecutive patients presenting with early-onset synovitis were studied by measuring rheumatoid factor (RF) titers and the percentage of oligosaccharide chains attached to the C gamma 2 domain of IgG that lack galactose (GAL[0]). After 2 years of followup, 39 patients (65%) had developed rheumatoid arthritis (RA), and 21 had developed a variety of other inflammatory joint diseases. A combination of RF positivity and GAL(0) levels above the age-corrected mean gave a positive predictive value for a diagnosis of RA in 94% of these patients. These observations may well have clinical utility.

Adult

Local injection treatment of tennis elbow--hydrocortisone, triamcinolone and lignocaine compared.

Corticosteroid injections are the mainstay of treating tennis elbow even though their effectiveness has not been well established by controlled studies. A survey of consultant rheumatologists confirmed a widespread preference for this treatment but they varied in their choice of steroid dose and preparation. We examined the value of some practices by comparing local injections of 2 ml 1% lignocaine with either 10 mg triamcinolone or 25 mg hydrocortisone made up to 2 ml with 1% lignocaine (Study 1). The investigation was conducted double blind. Within the first 8 weeks, pain relief was greater for triamcinolone than hydrocortisone although the differences were not statistically significant. The response to both steroid preparations was significantly better than for lignocaine up to this point but at 24 weeks, the degrees of improvement were similar for all three groups and many patients still had pain. Relapse was common. In a separate but similarly designed study, triamcinolone 10 mg was compared with 20 mg of the same agent. Improvements of pain were similar and followed the same time scale. Post-injection worsening of pain occurred in approximately half of all steroid treated patients in both studies and this was sometimes severe and persistent. It was less frequent amongst those given lignocaine alone. Skin atrophy was reported in all groups but was more frequent amongst those given triamcinolone in Study 1. In conclusion, more rapid relief of symptoms was achieved with 10 mg triamcinolone than with 25 mg hydrocortisone or lignocaine alone and there was less needed to repeat injections. Results obtained with 20 mg triamcinolone were similar to those of the smaller dose.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult

From one word to two words: repetition patterns on the way to structured speech.

This paper gives an account of the transition from one-word to multi-word utterances based on the productions of one child from age 1; 5.23 to 1; 8.15 in spontaneous interaction with her mother. The authors' interpretation of the observed development emphasizes: (1) the initial dissociation and later co-ordination of temporal chaining of elements on the one hand and meaning-relatedness between elements on the other; and (2) the psychological importance of repetition patterns for the change from single-word functioning to meaning-related and temporally-chained multi-word utterances, i.e. utterances that show the duality of patterning characteristic of human language.

Female

Estimating the prevalence of chronic respiratory disease.

A method is described for estimating the prevalence of chronic respiratory disease in a middle aged and elderly general practice based population, using the prescription of drugs in order to identify the disease. The prevalence estimates ranged from 15 per 1,000 in men aged 45-50 years to 62 per 1,000 in those aged 75-80 years. For women the corresponding values were 11 to 29 per 1,000. The estimates attained displayed the age and sex patterns expected on the basis of other data sources including morbidity surveys in the United Kingdom and the Netherlands. The similarity suggests that this may be a valid method for estimating quickly and cheaply the prevalence of certain diseases in the community.

Aged

Early detection of carpal erosions in patients with rheumatoid arthritis: a pilot study of magnetic resonance imaging.

A pilot study comparing standard radiography to magnetic resonance imaging (MRI) was performed on the wrists of 10 patients with early (anatomic Stage I or II) rheumatoid arthritis (RA). MRI was found to be superior to standard radiographs in 2 respects: (1) synovial inflammation was impressively demonstrated on T2 weighted images, whereas plain films merely suggested soft tissue swelling; and (2) T1 and T2 weighted images clearly revealed erosions of several carpal bones which were not noted on standard radiographs. Although the expense of MRI currently precludes its routine use in clinical practice, the apparent sensitivity of this diagnostic modality for detecting early changes in RA might make it an invaluable tool for therapeutic decision making or for assessing response in interventional trials.

Adult

Nursing careers: findings of a follow-up survey of graduates of the nursing education and administration certificate courses of the Department of Nursing Studies, University of Edinburgh, 1958-1975.

The paper discusses the findings of a survey of the career progress of graduates of certificate courses in nursing administration and education, between 1958 and 1975, at the Department of Nursing Studies, University of Edinburgh. Five sections are presented: age, sex, career patterns, educational attainments and scholarly work. Issues arising within these sections are discussed.

Administrative Personnel

Dietary fibre.

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Dietary Fiber