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Biomedical subjects

H Simon

Publications and source records attributed to H Simon.

At least 271 records · Page 15Linked to original sources
PubMed1980

[Computer tomography of aorto-coronary bypass (author's transl)].

Computer tomography is a non-invasive method for demonstrating occlusion or patency of an aorto-coronary bypass. The early results of computer tomographic investigations of 77 bypasses in 51 patients are described. CT diagnosis of bypass patency is well established, but further work will be required to determine the accuracy of computer tomographic diagnosis of bypass occlusion.

Arterial Occlusive Diseases↗
PubMed1980

[The colorectal carcinoma; pathological remarks (author's transl)].

A survey is presented on the incidence of colorectal carcinomas in the GDR, exogenous causes possibly being responsible for the increase in incidence, common screening methods, macro-anatomy and micro-anatomy of colorectal carcinoma, staging, prognosis, and pathways of metastases. The correlation between intestinal polypi and colorectal carcinoma as well as the frequency of their degeneration are also referred to. Adenomatous polypi (polypous adenoma), villous polypi (villous adenoma), and certain rare intestinal polypi, such as familial polyposis coli, multiple polyposis of the entire gastro-intestinal tract, as well as the Gardner- and Turcot-syndromes, are some of those polypi which depending on their size tend to malignant degeneration. Histological information provided by the pathologist is discussed in its value and importance for surgical practice.

Adult↗
PubMed1980

[The nose as reacting organ to thermal skin irritations (author's transl)].

The essential task of the nose is the optimal conditioning of inhaled air for gas exchange in the lungs. In the light of comparative studies concerning the anatomical structure of the nose men and animals, it is illustrated that the function of the human nose is essentially different from that of the animal. Investigations concerning the function of the nose and having competent evidential value man can only be achieved by studying the human nose itself. After a review of the previous investigations and their results, continuous and extensively irritation free measurement of the nasal mucosa with small thermistor probes which are inserted simultaneously into both lower meatus of the nose are described. Combined with the thermistor probes are phototransistors. For measuring the degree of swelling of the lower concha a coldlight-source is placed in the common meatus of the nose, without mucosa contact light transmission through the concha is measured by the phototransistor. The reaction of the nasal mucosa temperature and of the degree of swelling of the inferior nasal concha to caloric stimulation on one side and on both sides of the upper and lower extremity is investigated. The results of these investigations indicate a close reflex relationship between nasal mucosa and extremities. It is demonstrated that warm and cold stimulation on the one side of the lower extremity induces quick and intense reaction of the homolateral nose. Warm stimulation of the lower leg on both sides extends the reaction times of the nasal mucosa, while cold stimulation of both sides causes a distinct reduction of the reaction time. Cold stimulation on one side of the lower arm reduces the reaction time as compared with cold stimulation of lower leg. Further, it is demonstrated that the degrees of swelling are not joint absolutely with the change of temperature but can take there courses independently. Warm stimulation as well as cold stimulation cause, in a majority of cases, an immediate decrease in the degree of swelling. The corpus cavernosum reacts to thermocutaneous remote stimulation quicker than does the mucosa temperature.

Arm↗
PubMed1980

[Quantitative morphological investigations in livers and liver tumors after taking contraceptives (author's transl)].

Since the introduction of the orally applicable contraceptive steroids repeated reports have been published on the occurrence of side effects largely manifesting in the liver. By means of morphometrical and densitometrical evaluation of histological slide preparations of livers damaged by contraceptives (biopsies, operation material), qualitative and quantitative transitions between the individual degrees of the lesion up to malign cell transformation were registered by automated microscope picture analysis. It appeared that this cell transformation, like similar as in experimental hepatocarcinogenesis, is gradual process. Among the most remarkable cytopathological features are changes of nuclear and nucleolar size and of the sinusoid area and of the number of Kupffer's cells. The latter are clearly increased in hepatosis caused by contraceptives as compared with normal livers, they are reduced in the hepatocellular adenoma, and reach a value near zero in the carcinoma.

Adult↗
PubMed1980

[Cardiac effects of isoproterenol in the complex echocardiographic evaluation (author's transl)].

The cardiac response to isoproterenol was examined in 10 normal subjects by echocardiography. The complete qualitative and computer-assisted quantitative analysis of one-dimensional recordings of the left ventricle is combined with two-dimensional echograms. The results - including the well-known facts that cardiac output and the velocity of contraction are increased while the end-diastolic dimensions are partly decreased - indicate that the stroke volume is not significantly diminished in the supine position. In two cases it is even enlarged. Moreover, a "pseudo-Sam" and the changes of the systolic time intervals demonstrate the strong positive inotropic effect of the drug. The amplitude of the descent of the base movement is also enlarged. The velocity of relaxation is not as increased as the velocity of contraction in that part of the posterior wall which is hit by the echobeam. There is a remarkable dissociation between the Ecg and the actual cardiac movements. E.g., with isoproterenol the mitral valve opens during the ascending T-wave, while normally relaxation only starts after complete electrical repolarisation. The shortening fractions of the phases of the cardiac cycle induced by the drug as compared to the control state are determined. It is shown that shortening of the whole cardiac cycle causes the systolic phase to shorten to a nearly adequate ratio. The slow filling phase mostly shortens to the smallest while the rapid filling phase always shortens to the greatest ratio. We discuss all echocardiographic parameters that are used for this study and we demonstrate some limitations to the interpretation of time-dimension curves derived from M-mode echocardiograms. These are especially evident after a strong beta-sympathomimetic stimulation, because after the injection of isoproterenol the appearance of the septal echo-lines changes from one subjects to the other in a striking way.

Adult↗
PubMed1979

Immunochemical detection of N6-methyladenine in DNA.

Antibodies to N6-methyladenosine were produced in rabbit by means of immunization with N6-methyladenosine coupled to bovine serum albumin via periodate oxidation. Cross-reacting antibodies were removed by bovine serum albumin-Sepharose and appropriate nucleoside-human serum albumin absorbents. Nucleoside-specific antibodies were isolated by affinity chromatography of N6-methyladenosine-human serum albumin-Sepharose. The specificity of the purified antibodies has been demonstrated by complement fixation inhibition analyses using nucleoside analogues as inhibition than dAMP. Anti-N6-methyladenosine was used to detect N6-methyladenine in denatured DNAs from various sources by complement fixation. Practically no complement fixation has been found with DNAs containing no N6-methyladenine, such as calf thymus, salmon sperm, Micrococcus radiodurans, Streptomyces chrysomallus and Streptomyces hygroscopicus, whereas a weak reactivity occurred in the case of Bacillus subtilis DNA and Sarcina maxima DNA. For DNA from Proteus mirabilis, Escherichia coli K-12, E. coli B, E. coli WF+, lambda, T2 phages quantitative differences in the immunochemical reactivity were observed, which only partially correlate with the N6-methyladenine content of the DNAs. Other factors, influencing the accessibility of N6-methyladenine to the antibody-combining site have to be taken into consideration.

Adenine↗
PubMed1979

[Quantitative gated nuclear cardiography for noninvasive evaluation of left ventricular function].

In 43 patients with angiographically proven coronary heart disease and in 24 patients without heart disease, gated blood pool scintigraphy was done under resting conditions with 15 mCi 99mTcHSA in LAO projection. Scintigraphic data were collected in list mode by means of a gamma camera connected to a computer system (Siemens 330). A cumulative scintigram sequence with a time resolution of 100 frames/s was constructed using several hundred heart cycles of equal duration. After background correction volume curves of the left ventricle were obtained and the following parameters were calculated: EF, dV/dt max,dV/dt min. In all patients with coronary heart disease, these parameters were reduced depending on the severity of the stenotic lesion. The changes of dV/dt min and to a greater extend of dV/dt max were more pronounced than those of the EF. These results are in keeping with invasively obtained data which show that a decrease of myocardial compliance is one of the earliest manifestations of CHD. Quantitative gated nuclear cardiography allows, therefore, noninvasive evaluation of left ventricular function even under resting conditions.

Coronary Disease↗
PubMed1979

[Demonstration of left-ventricular contraction anomalies with the two-dimensional sector-scanner (author's transl)].

Echocardiographic findings were compared with those obtained by cardiac catheterisation in 134 patients. Echocardiography was performed in the standard plane of the long and short axes, as well as from the cardiac apex. After dividing the left ventricle into several segments wall movement was measured in them and compared with those obtained by ventricular angiography in the right and left anterior oblique positions. It was found that in patients with left-ventricular aneurysm, proven by left ventricular angio, there was complete conformity with regard to localisation and extent of the aneurysm between the two methods of investigation. In this group 79% of the demonstrated segments could be adequately assessed and, in 91%, agreed with the radiological findings. In the group of patients without aneurysm only 68% of the segments could be adequately assessed, and 77% correctly assessed wall movement when compared with the laevocardiogram. Tracing recorded from the cardiac apex gave especially good results in demonstrating the ventricle and its segments.

Adult↗
PubMed1979

[Prodromal symptoms of acute myocardial infarction (author's transl)].

75 out of 100 patients who had survived myocardial infarction, had had prodromal symptoms. 62 patients reported specific prodromi such as first manifestations of angina pectoris or increase in duration and intensity of angina pectoris which had existed for some time previously, and in some cases had been accompanied by general complaints. A further 13 patients had only general symptoms such as onset of dyspnoea, palpitations, or a drop in performance during the 3 months prior to the infarct. The primary manifestation of symptoms consisted of exercise-induced angina pectoris at the beginning of the defined prodromal period in most cases, whereas later in the course manifestations occurred in the form of exercise-independent and spontaneous angina pectoris. In 9 patients symptomatology changed and exercise-induced angina transformed either into spontaneous angina pectoris or permanent pectanginous pain. In 8 of these 9 patients infarction occurred within less than a week after the change of symptoms. Prodromi occurred with approximately the same frequency in anterior and posterior wall infarction. The same applied to the distribution between transmural and non-transmural infarction.

Aged↗