Search PubMed⌕ Search

Biomedical subjects

H Sill

Publications and source records attributed to H Sill.

59 records · Page 4Linked to original sources
PubMed1995

Hodgkin's disease developing after spontaneous remission of chronic lymphocytic leukemia.

We present a 71-year-old patient with chronic lymphocytic leukemia diagnosed 27 years ago. Initially, the disease was staged as Rai II and the patient suffered from secondary immunoglobulin deficiency. Nevertheless, no treatment was necessary at that time. Because of disease progression a single course of chemotherapy was given in 1984. During the following year there was a constant decline of the WBC, accompanied by normalization of the immunoglobulins; both have remained stable ever since that time. However, there was still residual bone marrow infiltration, indicating persisting CLL. In 1993 cervical lymphadenopathy occurred with acute onset. A diagnostic lymphadenectomy revealed Hodgkin's disease of the nodular-sclerosing subtype. The patient was staged as II-III according to the Ann Arbor Classification and underwent radiation therapy. Cytogenetic examination of the bone marrow revealed a normal karyotype with an inversion of chromosome 9. This case demonstrates the rate coincidence of two lymphoproliferative disorders in the same patient. The clinical course and the immunologic findings of this patient are presented, together with a review of the literature.

Adult↗
PubMed1991

The effect of varying albumin concentration and hydrostatic pressure on hydraulic conductivity and albumin permeability of cultured endothelial monolayers.

An in vitro model of the endothelial transport barrier was developed using bovine aortic endothelial cell monolayers cultured on a porous polycarbonate substrate. Hydraulic conductivity (Lp) was measured by a bubble tracking technique at varying pressure differentials and albumin concentrations. The effective albumin permeability (Pc) was determined by measuring the flux of fluorescent-labeled albumin across monolayers at varying hydrostatic pressures. Lp determined at pressure differentials between 5.0 and 10 cm H2O demonstrated a strong dependence on albumin concentration, decreasing approximately 10-fold from 21.3 x 10(-7) +/- 3.18 x 10(-7) cm/sec/cm H2O (mean +/- SEM) at 0.0 g/dl to 2.35 x 10(-7) +/- 0.20 x 10(-7) cm/sec/cm H2O at 1.0 g/dl albumin. Increasing the albumin concentration from 1.0 to 4.0 g/dl reduced Lp by an additional 16% to 1.97 x 10(-7) +/- 0.17 x 10(-7) cm/sec/cm H2O. Furthermore, Lp was moderately dependent on the pressure differential, increasing by about a factor of two with a doubling of the pressure differential. The effective permeability (Pc) was also dependent on the pressure differential. At an albumin concentration of 4.0 g/dl, Pc increased from 1.37 x 10(-6) +/- 0.26 x 10(-6) cm/sec at 0.0 cm H2O to 5.06 x 10(-6) +/- 1.92 x 10(-6) cm/sec at 10 cm H2O. Analysis of Pc and Jv data, however, demonstrates that water and albumin do not share a common pathway in crossing the endothelial monolayer. These data suggest the existence of a large pore pathway for albumin. Thus, the in vitro system has many of the transport characteristics of intact vessels in vivo and should be useful for physiological studies of the endothelial transport barrier.

Albumins↗
PubMed1989

[Expression of class I and class II histocompatibility antigens in inflammatory kidney diseases].

MHC class I and II molecules serve as restriction elements for the presentation of antigen-specific T cell reactions and may be implicated in the process of cellular transformation. We have analysed the expression of MHC class I and II antigens including the associated invariant gamma-chain in 100 consecutive renal biopsies by a sensitive immunoperoxidase method using monoclonal antibodies against HLA-ABC, HLA-DR, HLA-DQ, HLA-DP and the invariant gamma-chain (Ii). HLA-ABC was expressed by almost all parenchymal cells except for podocytes. Staining for HLA-DR was found consistently in glomerular and interstitial capillary endothelial cells, in "dendritic" (LCA positive) and most infiltrating interstitial cells but not in mesangial and most extracapillary cells. Similar but weaker positivity was observed for HLA-DQ and -DP. HLA-DR positive infiltrating mononuclear cells in glomeruli were noted in acute glomerulonephritis (GN) and Lupus GN associated with enhanced staining of endothelial cells. In addition, HLA-DR was uniformly or focally expressed by predominantly proximal tubules in 80% of biopsies, especially IgA-GN, focal glomerulosclerosis, acute GN but also in 54% of cases with minimal change nephrosis. HLA-DP and -DQ were only positive in a limited number of HLA-DR positive tubules. The expression of the invariant gamma-chain was comparable with the reactivity for HLA-DR. In addition, all HLA-DR-positive tubules expressed the invariant gamma-chain. Subtyping of T cells in biopsies with DR-positive tubules and interstitial infiltrates (n = 20) showed a predominance of CD 4 positive cells in the majority of cases.(ABSTRACT TRUNCATED AT 250 WORDS)

Glomerulonephritis↗
PubMed1981

Lactation suppression with bromocriptine.

The efficacy and acceptability of bromocriptine in suppressing postpartum lactation was determined in a double blind study in which bromocriptine 2.5 mg twice daily for 14 days was compared with a placebo. Forty women who decide during the antenatal period not to breast feed entered the study. The bromocriptine treated group had significantly less mammary secretion and breast engorgement than the control group and also required less analgesia. The most noticeable side effects during the trial were dizziness, headache and abdominal pain. The only statistical difference between the two groups was a higher incidence of dizziness in the bromocriptine treated group.

Adult↗