[Possibilities of errors and false interpretations in isotope nephrography].
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Humans↗
Biomedical subjects
H Siewert
Publications and source records attributed to H Siewert.
[Antineoplastic effectiveness and toxicity of idarubicin (4-demethoxy-daunorubicin) in recurrent acute leukemias in childhood].
11 patients with refractory acute leukemia of childhood were treated with idarubicin per os. Bone marrow toxicity which was observed at a dose level of 60 mg/m2 p.o. (3 x 20 mg q 24 hrs p.o.) per 3 weeks was found to be the dose limiting factor. In contrast to the first phase I study of Tan et al. (16) the maximal tolerated dose in the present study was found to be lower at a level of 90 mg/m2 p.o. (3 x 30 mg/m2 p.o. q 24 hrs) per 3 weeks. Therefore, we recommend a dosage of 60 mg/m2 p.o. (3 x 20 mg/m2 p.o. q 24 hrs) per 3 weeks as a starting dose for phase II/III studies. 2 out of the 11 anthracycline pretreated patients (91-880 mg/m2) with acute leukemia reached a complete remission undergoing idarubicin p.o. as a single therapy.
Adolescent↗
[Effect of a 3-month-interval running exercise in combination with vasodilative therapy on microcirculation of the lower leg in peripheral arterial circulation disorders (stage I and II)].
The authors report results of a three-month-interval running exercise under continuous vasodilatory therapy (Radecol and Jupal) in cases of peripheral arterial blood disturbances (stage I and II). Apart from control examination with the whipping test, the ultra-sound-Doppler method, phlebemphraxis-plethysmography, the paper reports above all the effects of interval running on the peripheral microcirculation of the working muscles which were determined by means of Xenon-133-clearance-half-life. Independent of the type of drug therapy used, significant (1 per cent) improvements of peripheral haemodynamics were found regarding the therapeutic regime presented.
Adult↗