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Biomedical subjects

H Siegl

Publications and source records attributed to H Siegl.

33 records · Page 2Linked to original sources
PubMed1985

[Decompression of the optic nerve].

A case of a traumatic opticus lesion with frontobasal and temporal fracture was operated within the first two hours following the trauma. The vision was completely restituted. Interesting was the change of the pupil during the operation so that the amaurotic wide pupil was getting narrow similar to the uninjured one. In accordance with the further improvement, this observation was qualified as a sign of restitution. This case was selected from a series of 17 opticus decompressions.

Adolescent↗
PubMed1984

Importance of the adrenal cortex for development and maintenance of hypertension in spontaneously hypertensive rats.

Adrenal regeneration following complete bilateral adrenalectomy in spontaneously hypertensive rats (SHR) was used to study the significance of glucocorticoid and mineralocorticoid hormones for the development and maintenance of hypertension. Pre-hypertensive (5 weeks of age) and hypertensive (10 and 16 weeks of age) male SHR underwent adrenalectomy (ADN) and were kept on 0.9% NaCl. The rats were ether stressed at various intervals to assess adrenal steroid production. Following ADN of all three age groups the development or maintenance of hypertension depended on the presence of adrenal regenerates. Animals without signs of adrenal regeneration remained or became normotensive. There was a significant correlation between plasma corticosterone levels following ether stress and blood pressure. Aldosterone and corticosterone production of regenerates and of adrenal cortex of intact SHR was studied in vitro. Under basal condition and following ACTH stimulation both tissues produced similar amounts of corticosterone, however considerably less aldosterone was secreted by regenerates. Betamethasone substitution in adrenalectomized rats caused a dramatic increase of blood pressure which was attenuated by L-propranolol. Aldosterone had no significant effect on blood pressure. It is concluded that glucocorticoids play a permissive role in the development of hypertension presumably via alteration of sympathetic neurotransmission.

Adrenal Cortex↗
PubMed1976

Glomerular filtration rate and effective renal plasma flow following treatment with phenobarbital.

SPF-male rats were treated intraperitoneally with phenobarbital (30 mg/kg/day) or 0.9% sodium chloride for 4 days. Endogenous creatinine clearance in conscious rats and inulin clearance in nondiuretic rats under inactin anesthesia were measured 24 hr following the last injection. In an additional group of treated rats diuresis was induced by sodium chloride and mannitol and then inulin- and PAH clearance were measured simultaneously. Following 4 days treatment with phenobarbital, endogenous creatinine clearance and inulin clearance were not significantly different in control and phenobarbital-treated animals. In contrast significant changes were found in urine volume and PAH clearance in the phenobarbital-treated animals. These results do not reflect any change in glomerular filtration rate, but might be attributed to an increase in renal plasma flow or an activated tubular transport system following phenobarbital administration.

Anesthesia↗