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Biomedical subjects

H Shimazu

Publications and source records attributed to H Shimazu.

At least 163 records · Page 9Linked to original sources
PubMed1980

A histopathological study on pyloric ulcer.

After the pyloric ulcer was defined as a peptic ulcer occurring at the pylorus or having its centre in the prepyloric region within 2 cm from the pylorus, its histopathological features were studied on 94 pyloric ulcers in 88 surgically resected stomachs. 72.3 per cent of these ulcers were less than 1.0 cm in diameter. The incidences of UI-II, III and IV ulcers were almost equal, and the majority of UI-II and UI-III ulcers were found in scarring stage in the specimens. These pyloric ulcers were classified into three types according to whether the centre of ulcer is situated above (Type-1), on (Type-2) or below (Type-3) the pylorus. Type-1 ulcers wre the most frequent, their incidence being 70.2 per cent. On histologic examination, it was observed that duodenal gland area extended over the pyloric antrum in 90 per cent of the specimens. Contrary to the mucosal rule of Oi for the genesis of peptic ulcer, pyloric ulcers were located in poric gland gland are in 30.9 per cent and on the glandular boundary in 57.4 per cent. Only in 11.76 per cent, the ulcer developed in duodenal gland area. In 68.2 per cent, pyloric ulcer was associated with other gastric or duodenal ulcers. The majority of these coexisting gastric ulcers occurred in the pyloric gland area adjacent to the antrofundic border, and all the duodenal ulcers in the proximal duodenum. Moderate or severe atrophic changes in gastric antral mucosa were found in a large number of the specimens with coexisting gastric ulcer, whereas the changes were less pronounced in those with pyloric ulcer alone.

Adult↗
PubMed1980

Postsynaptic inhibition underlying spike suppression of secondary vestibular neurons during quick phases of vestibular nystagmus.

Synaptic mechanisms of spike suppression of vestibular neurons during quick phases of vestibular nystagmus were investigated by intracellular recording in the rostrolateral part of the cat medial vestibular nucleus. When repetitive spike discharges of vestibular neurons were abruptly suppressed at the quick phase, the membrane potential shifted steeply in the hyperpolarizing direction. After the commissural IPSP was inverted into depolarization by intracellular injection of Cl-ions, the hyperpolarizing deflection of the membrane potential at the quick phase was also inverted into a depolarizing potential. The results indicate that an abrupt generation of IPSPs in vestibular neurons underlies the quick phase suppression of spike activity in these neurons.

Abducens Nerve↗
PubMed1980

Axonal branches and terminations in the cat abducens nucleus of secondary vestibular neurons in the horizontal canal system.

Single vestibular neurons functionally identified as secondary neurons receiving primary afferents from the horizontal canal in the cat were intracellularly stained with horseradish peroxidase (HRP). The vestibular neurons projecting to the ipsilateral abducens nucleus distributed terminal branches in a relatively narrow band in the nucleus. The stem axon of contralaterally projecting vestibular neurons bifurcated into ascending and descending branches in the contralateral medial longitudinal fasciculus. The collaterals emerging from these branches distributed terminals in a relatively wide area in the abducens nucleus. Collateral branches extended into the medial vestibular nucleus, prepositus hypoglossi nucleus and reticular formation.

Abducens Nerve↗
PubMed1980

[Intravenous chronic toxicity of lentinan in rats: 6-month treatment and 3-month recovery (author's transl)].

Chronic toxicity of lentinan was studied in male and female JCL : SD rats. Lentinan was given intravenously into tail vein. Dosage levels employed were 0 (5% mannitol), 0.01, 0.1, 1 (with or without dextran), and 10 mg/kg/day for 6 months in a volume of 1 ml/100 g body weight. After 6 months, the treatment was discontinued and a recovery study was performed for 3 months. Rats receiving 10 mg/kg had redness and necrosis of the tail, the treatment was stopped at week 5, and the rats were sacrificed. Rats receiving 1 mg/kg showed redness of the ear, tail, and scrotum, which was remarkable in the 2nd and 3rd months. Body weight gains were not adversely affected. Laboratory examinations revealed an increase in leukocyte count, decreases in differential eosinophil count and platelet count, and an increase in serum beta-globulin level in drug-treated rats. At autopsy after 6 months, rats from the drug-treated groups had pulmonary hemorrhage and enlargements of the spleen and mesenteric lymph nodes. Histologic changes attributable to treatment included (1) activation of reticulo-endothelial system such as small epithelioid cell nodule in the liver, spleen, and mesenteric lymph nodes, and mobilization of Kupffer cells; (2) arteritis in various organs, especially notable in the spleen, testis, and epididymis ; (3) hemorrhage in the lung; and (4) hypospermatogenesis. All these changes described above had a propensity to recover. The maximum no effect level was estimated to be less than 0.01 mg/kg in the present study in male and female rats.

Animals↗
PubMed1980

G-cell populations in resected stomachs from gastric and duodenal ulcer patients.

The G-cell population in the pyloric antrum and proximal duodenum was studied quantitatively by immunofluorescence in specimens from 10 gastric and 12 duodenal ulcer patients. In both groups, G-cell density was highest in the pyloric antrum and much lower in the intermediate zone and proximal duodenum, and G-cell counts were statistically higher at the greater than the lesser curvature. The estimated total number of G cells in the whole pyloric antrum including the intermediate zone in the duodenal ulcer group was (1.806 +/- 0.347) x 10(7), this value was significantly greater (P less than 0.05) than that of (0.872 +/- 0.207) x 10(7) in the gastric ulcer group. This difference was due to a higher incidence of intestinal metaplasia and a decrease in the thickness of the antral mucosa in the latter group. The estimated total number of G cells showed a significant negative correlation not only with the patient age (P less than 0.01) but also with the degree of intestinal metaplasia of the antral mucosa (P less than 0.01) in both duodenal and gastric ulcer patients.

Adult↗