Search PubMed⌕ Search

Biomedical subjects

H Shimada

Publications and source records attributed to H Shimada.

At least 937 records · Page 52Linked to original sources
PubMed1981

[Detection of the cardiac anomalies before birth by cross-sectional echocardiography (author's transl)].

Cross-sectional echocardiography has enabled us to demonstrate foetal cardiac structures, however, only a few studies have been reported. This report deals with a recently experienced foetus with double outlet right ventricle )DORV) diagnosed by this technique, confirmed by angiography and autopsy after birth. A 24-year-old pregnant woman with 24 weeks foetus underwent echocardiographic studies to evaluate the foetal heart because of its bradycardia. The cross-sectional echocardiogram showed a quite abnormal finding; i.e., two great arteries arose from the single ventricle which had coarse trabeculations. This finding suggested either DORV or single ventricle. The foetus was born at 40 weeks as a girl weighted 3040 g, and cyanosis was not observed. At one month of age, she began to experience increasing cyanosis by crying, and admitted to Keio Hospital for further examinations. She was performed catheterization and angiography, and was diagnosed as DORV. Cyanosis and dyspnea developed gradually and she died at the age of 2 months. Autopsy revealed DORV, polysplenia and dextrocardia.

Adult↗
PubMed1981

[Heart sounds and heart murmurs in progressive muscular dystrophy of Duchenne type (author's transl)].

Phonocardiographic and echocardiographic investigation was performed in patients with progressive muscular dystrophy of Duchenne type (PMD). The clinical materials consisted of 90 patients with PMD (aged 8 to 21 yrs, a mean of 14.5), and 90 normal subjects (aged 6 to 19 yrs, a mean of 11.7). The patients with PMD were classified into 8 stages from the mildest, S(1), to the severest, S(8), according to Swinyard-Deaver' criteria. In the 90 normal subjects the diminished first heart sound was noted in 12 cases (13.3%), presystolic murmurs in 4 cases (4.4%), and diastolic rumbles in 9 cases (10%), whereas, in the patients with PMD the diminished first heart sound was noted in 47 cases (52.2%), presystolic murmurs in 41 cases (45.6%), and diastolic rumbles in 44 cases (48.9%). There was a significant difference in the incidence of the above-mentioned three phonocardiographic findings between the PMD patients and the normal subjects. But there was no significant difference in the incidence of a systolic click between these two groups. The incidence of the diminished first heart sound increased with the progress of Swinyard-Deaver' classification. A presystolic murmur was observed with the highest incidence in the stage of S(8). The incidence of a rumble was also augmented with increasing severity of the disorder from the stages of S(1) to S(7), but decreased in S(8). Another attenpt was made to relate the phonocardiographic findings to those of the echocardiogram. In the cases with anterior mitral leaflet fluttering, there were diastolic rumble in 69% whereas 16.7% of the patients without anterior mitral leaflet fluttering had diastolic rumbles. In two-dimensional echocardiography, the anterior and posterior mitral leaflets looked like pennants fluttering in the wind. All these observations positively indicate that anterior mitral leaflet fluttering was closely associated with the genesis of rumbles. Consequently, it can be concluded that the diminished first heart sound, presystolic murmurs and diastolic rumbles might be useful clinical signs in the assessment of the myocardial involvement in PMD.

Adolescent↗
PubMed1980

Carcinoma of the prostate in childhood and adolescence: report of a case and review of the literature.

This paper reports a case of carcinoma of the prostate in an 11-year-old boy. The clinical findings were characterized by a mass in the prostatic region, extensive osteoblastic bone metastasis, and normal serum acid phosphatase. Autopsy demonstrated an undifferentiated tumor, which probably originated from the outer gland of the prostate. Metastases to the bones, liver, lungs, and the lymph nodes were present. Light and electron microscopic studies revealed undifferentiated neoplastic cell, which is in contrast to the usual adenocarcinoma in older individuals. Histochemical examination failed to demonstrate acid phosphatase activity within the tumor cells. The authors considered that this tumor probably originated from immature basal cells of the prostatic gland. Review of the literature disclosed 15 cases of carcinoma of the prostate in individuals under 21 years of age. These cases were also characterized by an undifferentiated appearance of tumor cells and normal serum acid phosphatase level.

Acid Phosphatase↗
PubMed1980

Lack of induction of dominant lethal mutations in male mice by nalidixic acid.

Nalidixic acid (NA) in single or in 5 consecutive daily doses of 100 or 1000 mg/kg produced no dominant lethal mutational effects in male ddY strain mice during an 8-week mating schedule. Ethylmethanesulfonate (EMS), used as a positive control, produced dominant lethal mutations in the first and second weeks.

Animals↗
PubMed1980

[Evaluation of nephrotoxic site in rat proximal tubule: intrarenal distributions of three enzymes and effects of mercuric chloride and gentamicin on their excretion into urine (author's transl)].

Intrarenal distributions of three enzymes, gamma-glutamyl transpeptidase (gamma-GTP), alkaline phosphatase (Al-p) and leucine aminopeptidase (LAP) were determined using six segments of nephrons. These enzymes were localized only in the proximal tubule. Intra-proximal distributions of the enzymes, however, were not uniform. The order of each enzyme activity in three segments of the proximal tubule, S1, S2 and S3 was as follows: Formula: (See Text) With subcutaneous administration of HgCl2 (1.0 mg/kg/day), urinary excretions of all three enzymes were increased from the 1st to the 2nd day and then decreased to the control level. However, after intraperitoneal administration of gentamicin sulfate (40 mg/kg/day), only Al-p activity in urine was significantly increased on the 1st day. Because of the lack of increasing blood levels of these enzymes after treatment, increased urinary excretions of the enzymes probably originate from the kidney, particularly the proximal tubule. The prominently increased excretion of gamma-GTP and LAP after HgCl2 treatment means that HgCl2 might damage S2 and S3, because the excretory patterns of the three enzymes were similar to their distribution profiles in S2 and S3. On the other hand, the toxic action of GM may be localized in S1 portion, in which Al-p activity proved to be highest among the three enzymes.

Alkaline Phosphatase↗
PubMed1980

Cell, tissue and organ banks in Japan with special reference to the study of premature aging.

Cell and tissue banking facilities exist in Japan in a) 7 laboratories of national institutions, for the conservation of living organisms, b) the Tokyo Metropolitan Institute of Gerontology, operating its own bank of cultured human cells for aging research, c) the Institute of Physical and Chemical Research which is performing pilot experiments for cell research and cell banking, and d) more than 50 laboratories operating small-scale repositories in the fields of cancer research, virology, genetics, gerontology, radiation biology, cell biology, and cell physiology. Except for several eye banks, no organ banks have yet been developed in Japan. As an example of cell and tissue banking, some details for studying a premature aging syndrome, i.e., Wistar's syndrome (WS) is shown. Four cases of autopsied WS patients and more than 20 clinically traced WS patients have been reported in Japan. At present, cultured skin cells from more than 20 WS patients and skin tissues from several WS patients for the initiation of culture, are on deposit and under investigation.

Cell Line↗