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Biomedical subjects

H Shibuya

Publications and source records attributed to H Shibuya.

At least 415 records · Page 23Linked to original sources
PubMed1980

Increase in pituitary melanocyte-stimulating hormone activity of genetically obese (ob/ob) mice.

Melanocyte-stimulating hormone (MSH) activity was measured in the pituitaries of genetically obese and lean control mice using the frog skin bioassay. Obese mice pituitaries demonstrated very significantly elevated levels of biologically active MSH when compared to their lean littermates. These results support the hypothesis that the elevated levels of pituitary hormones found in obese mice possesses true biological activity.

Adrenocorticotropic Hormone↗
PubMed1980

Effects of washing on phytohemagglutinin responsiveness of lymphocytes from irradiated patients.

The peripheral lymphocytes from irradiated patients generally have a reduced capability to respond to phytohemagglutinin (PHA). Whether a relationship exists between PHA-responsiveness and chromosome aberration frequencies was examined by washing the lymphocytes with culture medium. The results indicate that the defect in lymphocyte activation in patients receiving radiation therapy was caused by some reversible changes in the lymphocyte membrane directly associated with radiation exposure rather than by a radiation induced suppressor substance secondarily acting on the lymphocyte membrane.

Adolescent↗
PubMed1980

Peripheral lymphocyte count in untreated non-Hodgkin's lymphoma patients and their lymphographic findings.

The relation between grades of foaminess in lumbar, iliac and inguinal nodes on bipedal lymphograms, and peripheral lymphocyte counts was assessed in patients with untreated non-Hodgkin's lymphoma. The lymphocyte counts were widely distributed in and around the normal range in patients with normal lymphographic findings, but in patients with increased grades of foaminess they were depressed to a marked degree. The decrease in peripheral lymphocyte counts in patients revealing no pathological grades of foaminess may be caused by the occult abdominal non-Hodgkin's lymphoma or may suggest the impending extension of the disease in these nodal chains.

Humans↗
PubMed1978

beta-Endorphin is associated with overeating in genetically obese mice (ob/ob) and rats (fa/fa).

Small doses of the opiate antagonist naloxone selectively abolished overeating in genetically obese mice (ob/ob) and rats (fa/fa). Elevated concentrations of the naturally occurring opiate beta-endorphin were found in the pituitaries of both obese species and in the blood plasma of the obese rats. Brain levels of beta-endorphin and Leu-enkephalin were unchanged. These data suggest that excess pituitary beta-endorphin may play a role in the development of the overeating and obesity syndrome.

Animals↗