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Biomedical subjects

H Shibuya

Publications and source records attributed to H Shibuya.

At least 325 records · Page 18Linked to original sources
PubMed1988

[Frequent occurrences of an enlarged submandibular gland following interstitial irradiation therapy in patients with cancer of the tongue].

A submandibular gland enlargement produces complications in the diagnosis of a nodal metastasis during the follow-up period in patients who have been given interstitial irradiation therapy for their oral cancers. Thus, a retrospective study has been made of the records of such affected patients, to accumulate knowledge regarding the frequency, the time of appearance, and the symptoms leading to the gland enlargement. Among 155 cases of squamous cell carcinoma of the tongue, 73 cases were selected for this study by the following criteria: (1) the patients were free of metastatic adenopathy, (2) they had been interstitially irradiated, and, (3) they were followed-up without surgical treatment for more than 6 months after the radiotherapy. Gland enlargement was found to have developed in 70% of the studied patients, that is, in 49 of the 73 cases within 9 months after radiotherapy.

Brachytherapy↗
PubMed1988

Regulation of cytokine gene expression: gene activation in type I IFN and IL-2 systems.

Cytokines represent essential soluble mediators in cell-to-cell communication and they are known to play crucial roles in many biological processes, including viral infection, inflammation and immunity. We have been focusing on two cytokine systems, the interferon (IFN) and interleukin 2 (IL-2) systems each of which respectively plays a key role in viral infections and the immune response. In both cases, expression of those cytokines and, in the case of IL-2 system, the receptor is tightly regulated at the transcriptional level. Recent studies in our laboratory as well as others have uncovered the mechanism(s) operating in the regulation of those genes and have provided further insights on how the two cytokine systems operate and what is the biological significance of gene regulation in these systems. Here, we summarize the current understanding of the IFN system and IL-2 system in the context of host defense against viral infections and T cell neoplasms, respectively.

Amino Acid Sequence↗
PubMed1988

[Results of radiation therapy in extranodal non-Hodgkin's lymphoma of the head and neck--a study of the Japan Lymphoma Radiation Therapy Study Group].

Extranodal non-Hodgkin's lymphoma (NHL) in the head and neck except Waldeyer's ring treated with radiation were analyzed. No definite difference was observed both in actuarial and relapse-free five-year survival rate between stage I and II. There was a high survival rate with orbital NHL in which most of the patients occupied with favorable histology. Prognosis of the disease was highly influenced by the histologic subtype; five-year survival was 91.4% in DWDL, 77.2% in the DM, 52.0% in DPDL and 51.7% in DH. Application of histologic classification with the Working Formulation was also recommended. There was a high incidence of extranodal relapses to bone and/or soft tissue from the lesions with nasal cavity, paranasal sinus and oral cavity.

Adolescent↗
PubMed1987

Multiple primary cancer risk in patients with squamous cell carcinoma of the oral cavity.

During 6375 patient-years of observation, 136 new cancers developed in 117 of 1429 patients with squamous cell carcinoma of the oral cavity. The risk of multiple cancers was excessive in the upper digestive or respiratory tract in patients with squamous cell carcinoma of the oral cavity, accounting for 87 (64%) of the 136 later cancers. In addition, multiplicity of cancers was site-specific, being common in the oral cavity-esophagus-lung axis and uncommon in sites such as the maxillary sinus and epipharynx. In addition, the observed-to-expected ratio was different in each site of the oral cavity-esophagus-lung axis, i.e., 57.5 for the oral cavity and pharynx, 12.0 for the esophagus, 7.3 for the larynx, and 2.0 for lung cancers.

Carcinoma, Squamous Cell↗
PubMed1987

Ultrasonically guided staging splenic tissue core biopsy in patients with non-Hodgkin's lymphoma.

Ultrasonically guided tissue core biopsy of the spleen was undertaken in eight patients with previously untreated non-Hodgkin's lymphoma in the staging procedure. In all cases, the tissue core specimens that were biopsied were sufficient to diagnose the presence of involvement of non-Hodgkin's lymphoma, and two of the eight were found to have histologic involvement. There was no complication in this series. It was concluded that this is a safe and reliable technique for the staging of malignant lymphoma.

Adult↗
PubMed1987

Interferon-beta gene regulation: tandemly repeated sequences of a synthetic 6 bp oligomer function as a virus-inducible enhancer.

Evidence is presented that virus-induced transcriptional activation of the human interferon-beta gene is mediated by repeated sequence units each consisting of 6 bp. The repeated units are present in the region between -65 and -109 relative to the cap site. We chemically synthesized the "consensus" DNA sequence units and tested their ability to confer virus inducibility on cognate and noncognate promoters. Most of such sequence units when tandemly repeated indeed mediate virus-induced activation of the promoter sequences. The most efficient sequence unit, AAGTGA, contributes incrementally in virus-induced activation of transcription and manifests properties of an inducible enhancer. Evidence is also provided that suggests that interaction of a positive regulatory factor(s) with this regulatory region.

Animals↗
PubMed1987

Stage I and II Waldeyer's ring and oral-sinonasal non-Hodgkin's lymphoma.

Sixty-six patients with Ann Arbor Stage I and II Waldeyer's ring and oral-sinonasal non-Hodgkin's lymphoma are presented. Ten-year survival was better for the 32 patients with Waldeyer's ring non-Hodgkin's lymphoma (Stage I, 83%; Stage II, 75%) than for the 34 with oral-sinonasal non-Hodgkin's lymphoma (Stage I, 47%; Stage II, 50%). Diffuse large cell lymphomas were common in patients with Waldeyer's ring involvement (59%). In those affected in the oral-sinonasal region, 38% had high-grade lymphoma. There was a high incidence of extranodal relapses outside of the gastrointestinal tract in patients with oral-sinonasal lymphoma (10 cases). Gastrointestinal tract relapse occurred commonly in patients with Waldeyer's ring lymphoma and was found in five cases.

Adolescent↗
PubMed1987

Evidence for aberrant activation of the interleukin-2 autocrine loop by HTLV-1-encoded p40x and T3/Ti complex triggering.

In this study we provide evidence that distinct DNA sequences within the 5'-flanking regions of the genes for interleukin-2 (IL-2) and its receptor (IL-2R) are involved in human T-cell-specific activation of transcription by p40x, a product of human T cell leukemia virus type I (HTLV-1). The same DNA sequences appear to be responsible for induction of the genes in a T cell line, Jurkat, by mitogens. Although the IL-2 gene sequences are activated by p40x with much lower efficiency than the IL-2R gene sequences, they are synergistically activated by the p40x expression and subsequent extracellular stimulation by Concanavalin-A or anti-T3. We propose a model for two-step activation of the IL-2 autocrine loop in ATL development.

Cell Line↗
PubMed1987

Dopaminergic agents affected neuronal transmission of cholecystokinin in the rat brain.

In order to study the interaction between cholecystokinin (CCK) and dopamine (DA), we prepared an anti-CCK-8 antibody with low cross reactivity, and observed effects of administered various dopaminergic agents on CCK-immunoreactivity (CCK-IR) in discrete brain regions of rats. CCK-8 IR (boiling water extraction) and CCK-33 IR (acetic acid extraction) were also measured in the same sample. A single administration of haloperidol decreased the CCK-8 IR in the corpus striatum and that of racemic sulpiride significantly decreased the CCK-8 IR in the frontal cortex and the limbic system. In contrast, a single administration of apomorphine or methamphetamine increased the CCK-8 IR in the same regions. These findings suggest that an acute response of the CCK system to administered dopaminergic agents may be due to a change in the rate of release of CCK-8, but not to a change in its synthesis in areas in which DA neurons originating in the midbrain innervate. After chronic administration of racemic sulpiride or methaphetamine, CCK-8 IR in various brain regions exhibited a tendency close to that of control.

Animals↗
PubMed1987

The chronic administration of dopamine antagonists and methamphetamine changed the [3H]-cholecystokinin-8 binding sites in the rat frontal cortex.

The specific cholecystokinin (CCK) binding in the slide-mounted tissue sections of the rat frontal cortex was measured with [3H]-CCK-8. The binding was saturable, reversible, high in affinity, and inhibited by caerulein. The chronic administration of dopamine (DA) antagonists and methamphetamine (MAP) showed a tendency to increase the [3H]-CCK-8 binding sites (Bmax) in the frontal cortex. Long-term treatments with DA antagonists led to the depletion of CCK-8 and may have caused an observed proliferation of CCK-8 receptors in the frontal cortex.

Animals↗
PubMed1987

The role of radiotherapy in the management of adenoid cystic carcinoma of the head and neck.

Sixty-eight patients with adenoid cystic carcinoma (ACC) of the head and neck treated by radiation with or without surgery were reviewed. The tumors were located in the major salivary glands in 15 patients and in the minor glands of various sites, mostly in the palate and/or upper gum, in 53. The local control rate was naturally better in the patients with elective postoperative radiation and those with recurrent disease who underwent radiation after repeated surgery for the purpose of tumor reduction than in patients with residual and/or inoperable tumors. For localized tumors in the oral cavity or maxillary sinus, local control was excellent using brachytherapy or "trimodal" combined therapy (radiation, drugs, and minor surgery). The effectiveness of radiation seemed to be more significantly related to the size of the tumor than the dose of radiation. The prognosis of the patients with a predominantly "solid" histologic pattern was apparently worse and presented fulminating progression of the disease. Among patients with a histologically typical cribriform pattern and/or undetermined pattern, although distant metastasis developed frequently, the majority survived a relatively long period without functional or cosmetic disturbance to their normal activities associated with slow progression of the disease. In minor gland tumors, as long as the lesion was localized and a solid histologic pattern was unlikely, radical radiation could be considered an effective choice with the advantage of enhancing the quality of life for the patients.

Adolescent↗
PubMed1987

[Experimental study on rat hepatic injury by copper--effect of copper overload on the cholestatic liver induced by bile duct ligation].

In the cases of protracted obstructive jaundice, it is reported that there was a positive correlation between the hepatic copper concentration and the severity of destruction of the bile ducts. The author produced the model of obstructive jaundice in rats by common bile duct ligation and investigated whether additional copper overload can cause injury on the liver. The simple ligating procedure induced a significantly increased level of the copper concentration (p less than 0.001). The copper concentration of the group with the additional copper overload showed about an eighteen-fold increase in comparison with the group of the only ligation (p less than 0.005). Histologically, the group with the overload alone exhibited no significant finding. The groups with the ligation showed bile duct proliferation with subsequent fibrosis around portal areas (pericholangiolar fibrosis); however, the fibrosis in the group with an additional overload was more prominent than that without an additional overload. By the orcein stain, the positive granules in the group with the ligation alone were preferentially present in the liver cells around the proliferated bile ducts. The group with the additional overload exhibited diffuse and more pronounced staining. Ultrastructurally, the liver cells in the group with the additional overload contained lysosomes with electron-dense material, some of which showed a feature consistent with focal interruption of their membranes. By X-ray microanalysis, these lysosomes were revealed to include copper as well as sulfur. The sulfur was considered to represent copper-binding protein.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1987

[Results of radiation therapy of extranodal non-Hodgkin's lymphoma of the head and neck--a study of the Japan Lymphoma Radiation Therapy Study Group].

During the years 1972-81, 168 patients with extranodal Non-Hodgkin's lymphoma localized in the head and neck were treated with radiation. Five-year survival rates were 62% in stage I, 56% in stage II, and 91% in diffuse well-differentiated lymphocytic, 77% in diffuse mixed, 52% in diffuse poorly-differentiated lymphocytic and diffuse histiocytic each. Marginal relapse was rare after radiation therapy, but relapses were not infrequently noticed in distant extranodal sites. Bone and/or soft tissue relapses were frequently noticed in patients with lesions initially located in the nasal cavity, paranasal sinus and oral cavity.

Adolescent↗