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Biomedical subjects

H Shibata

Publications and source records attributed to H Shibata.

At least 685 records · Page 38Linked to original sources
PubMed1985

Present status of bone marrow transplantation in Japan.

One hundred and seventy three bone marrow transplantations (BMT) including 133 allogeneic, 17 syngeneic and 23 autologous BMT were recorded in Japan during the period between September, 1975 and March, 1984. The number of cases of BMT increased rapidly over the years, i.e., 16 cases in 1980, 27 in 1981, 39 in 1982 and 57 in 1983. All cases were treated in clean rooms, many of them receiving intensive gut decontamination containing vancomycin. In 110 cases with acute leukemia, the main causes of death were interstitial pneumonitis, relapse of leukemia, infection and GvHD. Favorable factors determined from 180-day survival were remission, no infection, low dose rate and fractionated total body irradiation (TBI), ABO minor mismatch and positive graft versus host reaction. Long-term survival of patients who received BMT during remission and were without infection amounted to 70% of acute lymphocytic leukemia (ALL) and 40% of acute myelogenous leukemia (AML) patients. Cyclosporin A (Cy-A) administered in 21 cases was compared with methotrexate (MTX) given in 20 cases. A statistically significant decrease of stomatitis was observed, while no difference in GvHD or survival was seen. There were seven cases giving a more than good response out of 11 cases treated with cyclosporin because methotrexate or immuran was ineffective or could not be administered due to toxicity. Such data suggest that allogeneic BMT is acceptable as a very promising form of treatment for acute leukemia in Japan.

Acute Disease↗
PubMed1985

[Radiation therapy for primary non-Hodgkin's lymphoma of the head and neck].

Thirty-seven previously untreated cases of primary non-Hodgkin's lymphoma in the head and neck were treated at our department from September 1977 through January 1983. The survival rate at three years by stage was 84% in stage I, 44% in stage II and 0% in stage III and IV. Stage, T- and B-cell markers, initial primary site, the level of lymph node involvement (UICC, 1978) and number were important prognostic factors. Chemotherapy in the pre- or post-radiation period was essential, especially in stage II. It was proved that adequacy of radiation portals with special reference to anatomical considerations was necessary.

Adolescent↗
PubMed1985

[Phase II study of etoposide (VP-16) in the form of oral capsules for malignant lymphomas].

Twenty-five patients with malignant lymphomas were treated with etoposide oral capsule 200mg/day for 5 days, repeated 3-4-weekly. Twenty-one cases were evaluable. CR was achieved in four cases (19.0%) and PR in six cases (28.6%). The most serious adverse effect of the drug was leukopenia. In one patient (6.7%) the leukocyte count was lower than 1,000/mm3. Gastrointestinal toxicities such as anorexia, nausea, vomiting and diarrhea occurred in about 66.7% of patients but were not serious; alopecia was observed in 65.2%. In conclusion, etoposide is considered effective for malignant lymphomas.

Administration, Oral↗
PubMed1985

[Therapeutic effectiveness of aztreonam on severe infections associated with hematologic disorders. Hanshin Infection Study Group].

One hundred and nine patients with infection accompanying hematologic disorders including leukemia and lymphoma were treated with aztreonam (AZT). Of the 90 patients in whom the efficacy could be evaluated, 17 (18.9%) responded markedly and 29 (32.2%) moderately, the effective rate being 51.1%. The efficacy rate classified according to infections was 25% in septicemia, 46.3% in suspected septicemia, 57.1% in pneumonia and 100% in urinary tract infection. The efficacy rate to the Gram-negative bacteria was 78.9% and to the Gram-positive bacteria was 20.0%. In 4 (66.7%) out of 6 patients in whom P. aeruginosa was the causative organism, AZT was effective. The efficacy rate was 52.2% in the 23 patients whose causative organisms were identified and 50.7% in 67 patients whose causative organisms were not identified. There was no significant difference in the efficacy rate between the patients who failed to respond to prior antibiotic therapy (53.6%) and those treated with AZT from the beginning. The initial neutrophil count did not affect the efficacy rate. Side effects which might have been caused by AZT were eruption and fever in 4 patients. Hepatic disorders and eosinophilia were observed in 7 patients. However, the relationship between AZT and these abnormal findings was not established. These results indicate that AZT is an effective and safe antibiotic for the treatment of infections accompanying hematologic disorders.

Adolescent↗
PubMed1984

Permeability increase in black lipid membrane induced by compound 48/80.

When compound 48/80, a potent histamine liberator, was added in the aqueous phase facing the black lipid membrane, the conductivity of the membrane was remarkably increased. Although valinomycin displayed a distinct selectivity for K+ movement, such selection for ionic permeability was not observed in the case of compound 48/80.

Animals↗
PubMed1984

Efferent projections of the interpeduncular complex in the rat, with special reference to its subnuclei: a retrograde horseradish peroxidase study.

Projections of the subnuclei of the interpeduncular complex were studied by the retrograde horseradish peroxidase technique in the rat. The pars caudalis and pars dorsalis magnocellularis project to the septum, hippocampus and entorhinal cortex; a part of the pars medialis and the pars paramediana, to the dorsal thalamus; all subnuclei, to the midbrain raphe; and the pars lateralis, to the dorsal tegmental nucleus.

Animals↗
PubMed1984

Microcirculatory responses to estradiol benzoate in chronic liver damage induced by carbon tetrachloride in the rat.

Microcirculatory responses to estradiol benzoate (ES) under condition of chronic liver damage induced by long-term administration of carbon tetrachloride (CCl4) was investigated in the rat. One hundred and five male rats were divided into the following groups receiving 0.1 mg/100 g body weight ES injected intraperitoneally 5 times per week: controls, exposed to CCl4 alone; rats treated with ES from the fourth week of CCl4 exposure; animals treated with ES from the 11th week of CCl4 exposure. In rats receiving CCl4 alone, liver cirrhosis was induced by 10 consecutive weeks of exposure. Microangiograms of the liver demonstrated conspicuous rarefaction of the vascular tree. On the other hand, animals treated with ES had neither atrophic liver nor rarefaction of the intrahepatic vascular tree. ES produced also intrahepatic neovascular proliferation in the cirrhotic liver. After long-term CCl4 administration, ES treated rats had extremely enlarged nodules with tumor-stain like findings, giving rise to a structure differing from hepatocellular carcinoma which latter generally displays a broom-swept appearance. It is concluded that in providing potent angiogenesis in the liver, ES protects the liver against microcirculatory dearangement and parenchymal damage induced by CCl4.

Angiography↗
PubMed1984

Biomechanical study on monocortical osteosynthesis for the fracture of the mandible.

In order to compare the rigidity of the fixation and resultant bone healing of monocortical versus bicortical osteosynthesis, biomechanical tests were performed in dogs. Use of a gnathotome made it possible to produce a mandibular fracture with minimal bone defect between fragments. An AO dynamic compression plate and a mini-plate were used for the fixation of each half side of the fractured mandible. The biomechanical tests revealed that bicortical osteosynthesis was superior to monocortical in the rigidity of the fixation. However, the results after removal of the plates, at 14 weeks postoperatively, showed that there was no apparent difference between the 2 sides. Monocortical osteosynthesis is useful in the treatment of mandibular fractures, except for fractures with bone defects, comminuted fragments and laceration of the lateral cortical bone.

Animals↗
PubMed1984

Oral surgery and hemodialysis.

A case of a hemodialysis patient with a palatal tumor is presented. The problems requiring surgical management were as follows: anemia, hyperkalemia, bleeding tendency, delayed wound healing and usage of drugs, especially antibiotics. The palatal tumor was diagnosed histologically as monomorphic adenoma.

Adenoma↗
PubMed1984

Breast cancer with osteoclast-like multinucleated giant cells.

A case of breast cancer containing osteoclast-like multinucleated giant cells was examined cytologically, light and electron microscopically to find morphological evidences suggesting the origin of the giant cells. There were multiple evidences showing the same carcinomatous origin of each cells including osteoclast-like multinucleated giant cells.

Biopsy, Needle↗
PubMed1984

Somatotopic representation of facial muscles within the facial nucleus of the mouse. A study using the retrograde horseradish peroxidase and cell degeneration techniques.

The somatotopic representation of facial muscles within the facial nucleus was investigated by means of the retrograde horseradish peroxidase and cell degeneration techniques in the mouse. The nasolabial muscle is represented in the dorsolateral, lateral, and dorsal intermediate subnucleus; the mentalis muscle, in the ventral intermediate subnucleus; the platysma, in the dorsomedial part of the dorsal intermediate subnucleus and along the lateral border of the dorsomedial and ventromedial subnucleus; the orbicularis oculi and frontalis muscle, in the dorsal portions of the dorsolateral, dorsal intermediate, and dorsomedial subnucleus; the rostral and caudal auricular muscles, in the dorsomedial and ventromedial subnucleus, respectively; and the caudal belly of the digastric muscle, in the suprafacial nucleus. The present study shows that the facial muscles are represented in an orderly fashion in seven subnuclei of the facial nucleus, as in other animal species.

Animals↗