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Biomedical subjects

H Seyfarth

Publications and source records attributed to H Seyfarth.

At least 19 recordsLinked to original sources
PubMed1987

[Perloline content in fodder grasses. 1. Quantitative determination of perloline].

A colorimetric method for the quantitative determination of perloline in fodder grasses was established. The comparison with the internationally used spectrofluorimetric method shows that the established method is applicable as a routine method. The average variation coefficient of the colorimetric method is 4.9%. The average rediscovery quota was 95.8% (93.8-99.0%).

Alkaloids↗
PubMed1982

[Influence of prenatal applicated centrophenoxine on the postnatal increase in weight of the Wistar rats (author's transl)].

It is found in the literature, that Centrophenoxine, an ester of Dimethylaminoethanol and p-Chlorphenoxyacetate, has a great influence on the increase in weight of embryos of Wistar-rats. In the light of the present researches on animals it is tested, if this adequate substance transformation effect of Centrophenoxine has a long lasting influence on the postnatal life, whereby the weight is considered as a parameter. Centrophenoxine was applied on the animals under test from 11-14 d post coitum that is during the time of embryogenesis. The test lasted over 5 generations. The animals were divided into 2 groups: In the first group Centrophenoxine was given to the first generation and the second to fifth generation of animals were paired each other; while in the other group each generation received this Centrophenoxine at the same time before birth. The weights of the young animals were taken at definite intervals and compared with that of the untreated control-animals as well as among themselves. The weight differences in the individual weighting times between the control and test groups were inconsiderable and were significant only in few cases. The results showed that Centrophenoxine applied prenatal has lost its weight increasing influence in the postnatal life. The reasons are discussed.

Animals↗
PubMed1982

[Investigations on the pharmacokinetics of apalcillin in man].

Plasma levels and urinary excretion was studied after i.v. bolus of 1000 mg (2S,5R,6R)-6-[(R)-2-(4-hydroxy-1, 5-naphthyridine-3-carboxamido)-phenylacetamido]-3, 3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid (apalcillin, PC-904) and after long-term infusion of 3000 mg apalcillin in volunteers of both sexes. For measuring the concentrations a cylinder agar diffusion test was used. The plasma levels decreased from 150 microgram/ml 2 min after injection to 100 microgram/ml 15 min p.a. and to 37 microgram/ml after 90 min. For the terminal half-life of elimination from plasma a value of 1.0 was calculated. After termination of the long-term infusion concentrations of 70-80 microgram/ml were found in plasma. In this case a terminal half-life of 1.5 h was calculated. Due to the fast half-life of elimination no cumulation will occur in the case of repetitive dosing. This suggestion is supported by the finding, that the mean transit time of 1.4 h is very short. On the other hand the substance is distributed so rapidly that therapeutic levels are reached 30 min after infusion. Using data from literature, a proportionality between dose and area under the plasma curve could be demonstrated in the range 1000-3000 mg apalcillin. Our results show that about 20% of the dose administered is found in urine. 10 h after application the urinary excretion is finished. No side effects were observed during the acute assays.

Adult↗