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Biomedical subjects

H Serre

Publications and source records attributed to H Serre.

At least 55 records · Page 3Linked to original sources
PubMed1976

[Antibody-dependent cytotoxicity of blood lymphocytes during rheumatoid polyarthritis].

Lymphocyte dependent-antibody cytotoxicity (LDAC) was studied in 29 patients with rheumatoid arthritis (RA) and 22 controls. A significant increase of cytotoxic index has been noted in RA patients (p less than 0.0001) whatever the ratio effector-target cells could be. There is a correlation between cytotoxic activity and so called "rheumatoid rosettes" (RR) level. This cytotoxic activity is linked to EA rosette forming cells without T cell markers or surface immunoglobulins, as shown by fractionation experiments. EA rosette forming cell depletion is followed by the disappearance of RR and a very important decrease of cytotoxic index. Cytotoxic activity is abolished after RR forming cell depletion while EA rosette level is nearly unmodified. RR forming cells belong to Fc receptor bearing lymphoïd population. They take place in EA rosette forming cell population. Increase of cytotoxicity in RA seems to be directly linked to these so called RR forming cells.

Adult↗
PubMed1976

[Chronic lymphoid leukemia and multiple myeloma].

The authors report a case of multiple kappa myeloma comboned with chronic lymphoid leukemia. The chronic lymphoid leukemia had evolved over a 13-year period in the classical manner, without serum or urnary monoclonal immunoglobulins. The multiple myeloma with blood and urinary kappa chains appeared suddenly with a typical clinical and radiological picture accompanied by renal insufficiency. Thd diagnosis was confirmed by the demonstration of both lymphocyte and plasmocyte cell proliferation and a study of the ultrastructure which showed the sarcomatous and secretory character of the plasmocytes. A study of plasmocyte subpopulation showed the proliferation of B lymphocytes. A combination of chronic lymphoid leukemia and multiple myeloma is exceptional. The physiopathological interpretation (mono or biclonal proliferation) is discussed in the light of current nosological conceptions concerning lymphoproliferative disorders.

B-Lymphocytes↗
PubMed1975

[Practical significance of HL-A groups in rheumatology].

Since 1972, several relations have been demonstrated between some HL-A antigens and some articular diseases. The W27 antigen frequency is highly increased in ankylosing spondylitis (88%) and in Reiter disease (78%) compared with controls (5%). In peripheral forms of psoriatic rheumatism, the W17 and HL-A13 antigens are more fréquent (24% and 15%) than in healthy subjects (4% and 5%). In central forms of psoriatic rheumatism, there is a relation with W27 (48%) and still, we do not know if this association concerns only spondylitis or also sacro-ileitis. The HL-A typing may be useful for the diagnosis of some rheumatic diseases, when they present atypical appearances. W27 possesses a considerable value for the diagnosis of ankylosing spondylitis. The relation between W27 and ankylosing spondylitis is clearly stronger than that between Waaler-Rose reaction and rheumatoid arthritis.

Arthritis, Reactive↗
PubMed1975

[Value of HL-A groups in diagnosis in rheumatology].

Since 1972, several relations have been demonstrated between some HL-A antigens and some articular diseases. The W27 antigen frequency is highly increased in ankylosing spondylitis (88%) and in Reiter disease (78%) compared with controls (5%). In peripheral forms of psoriatic rheumatism, the W17 and HL-A13 antigens are more frequent (24% and 15%) than in healthy subjects (4% and 5%). In central forms of psoriatic rheumatism, there is a relation with W27 (48%) and still, we do not know if this association concerns only spondylitis or also sacro-iletis. The HL-A typing may be useful for the diagnosis of some rheumatologic diseases, when for the diagnosis of ankylosing spondylitis. The relation between W27 and ankylosing spondylitis is cleanly stronger than that between Waaler-Rose reaction and rheumatoid arthritis.

Alleles↗
PubMed1975

Mitogens of B and T cells from peripheral blood in rheumatoid arthritis.

Patients with rheumatoid arthritis (RA), 36 cases, and normal subjects, 49 cases were studied by lymphocyte cultures stimulated by phytohemagglutinin (PHA), Concanavalin A (Con A), pokeweed mitogen (PWM) and Con A convalently bound to Sepharose 4 B (Con A-S). The comparisons between the two groups showed a significant difference between the RA lymphocytes and the control lymphocytes stimulated by PHA and Con A. However, no statistical difference was found between the two lymphocyte populations stimulated by PWM and Con A-S. In order to determine the lymphocyte population stimulated by each mitogen, separation of B and T cells from peripheral blood was performed according to the ability for the T cell population to bind the sheep red blood cells (rosette-forming cells). The T cell-rich population was only stimulated by PHA, Con A and PWM. Although the T cell-depleted population showed no response to these mitogens, a response to Con A-S was elicited.

Adult↗
PubMed1975

Production of MIF-like supernatants by rheumatoid arthritis lymphocytes stimulated by immunoglobulin G.

Patients with rheumatoid arthritis (RA), patients with positive tuberculin (PPD) skin-tests and controls were studied. The lymphocytes from these groups were cultured in serum-free medium to obtain cell-free supernatants. These lymphocyte cultures were pre-incubated with the appropriate antigen or reconstituted after removal of the cells. Supernatants from RA lymphocytes stimulated in vitro by IgG induced an inhibition of the leucocyte migration, as well as the supernatants from tuberculin-sensitized lymphocytes. However, supernatants from non-RA lymphocytes or tuberculin-unsensitized lymphocytes did not show such an inhibition. These MIF-like supernatants have been studied by Sephadex G-100 gel filtration. A MIF activity has been found for PPD and IgG supernatants between the chymotrypsinogen (MW 23,000) and the lysozyme (MW 17,000). This seems to agree with the classical region where MIF can be usually isolated.

Arthritis, Rheumatoid↗
PubMed1975

[Sarcomas associated with Paget's disease].

The authors report 12 cases of Paget's disease with sarcomatous degeneration that were observed among 311 patients with Paget's disease hospitalized in the Montpellier Rheumatology Clinic. They compare their experience with information they were able to extract from the literature in French and English. The frequency of such degeneration in cases of Paget's disease is difficult to determine but did not appear to exceed 1%. Degeneration rarely occurred before the age of 50 years, affected men twice as frequently as women, and occurred particularly in cases of diffuse Paget's disease, mainly in the femur or the humerus; the rachis was rarely affected. Pain was the main symptom, was practically constant, was remarkable because of its permanence and its intensity. Tumefaction was frequently seen. Pathological fractures were seen in almost a third of the patients with sarcomas of the long bones. Radiculo-medullary compression characterized the rare cases with involvement of the vertebral column or the sacrum. Radiography showed rupture of cortical layers with invasion of the soft parts without any periostal reaction. Histological investigation confirmed the diagnosis by demonstrating one of the three types of osteogenic sarcoma: osteosarcomas were the most frequent. Less frequently giant-cell sarcomas or reticulosarcomas were found. The affected patients nearly always died, survival at five years being rare. Treatment, amputation or radiotherapy, was disappointing.

Aged↗
PubMed1975

[Lymphocytic subpopulations implicated in the rheumatoid rosette phenomenon].

The significance of the phenomenon of rheumatoid rosettes (RR) was studied in 21 subjects suffering from rheumatoid polyarthritis (RP) and in 16 controls. Certain technical factors influenced the prevalence of RR. Thus the number of RR increased in the RP patients and the controls with increase in the number of sensitized 0 Rhesus - red corpuscules; nevertheless there was a significant difference between the results obtained with the RP patients and the controls. The length of incubation and the temperature played an important role: prolonged contact times (30 min to one night), particularly at 4C considerably increased the numbers of RR, which reached 10 per cent both, in the controls and in the RP patients. The separation of lymphocytes by filtration through nylon according to Greaves' technique was followed by a study of the T cells (E rosettes), the B cells (surface immunoglobulins), and the RR. In all cases (RP and controls), the numbers of RR increased after filtration through nylon which retained the B cells. Separation of the lymphocytes by the centrifuging of the E rosettes showed that the proportion of RR was clearly higher in a population rich in B lymphocytes and lower in a population rich in T lymphocytes. Futhermore, filtration through nylon of cell suspensions rich in B lymphocytes showed a considerable rise in the RR and parallel drop in the number of B cells. Reduction of the RR by centrifuging did not affect the numbers of T or B cells. In the light of these results, it seems that the cell responsible for the formation of the RR does not have the characteristics of either the T or the B lymphocytes: a lymphocyte carring a receptor for the fragment Fc of the immunoglobulins (K cells) could be involved. In this case, the RR should be related to the EA rosettes of which they perhaps represent and active fraction.

ABO Blood-Group System↗