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Biomedical subjects

H Selye

Publications and source records attributed to H Selye.

At least 181 records · Page 10Linked to original sources
PubMed1966

Mast cells and necrosis.

Subcutaneous injections of normally well tolerated amounts of hypertonic NaCl or urea solutions produce extensive topical necroses in rats systemically treated with various mast-cell dischargers and mast-cell products. This response is considered to be closely related to mitast-cell function, for it cannot be duplicated by systemic treatment with a variety of other agents.

Animals↗
PubMed1966

Thrombohemorrhagic response to noradrenaline following heterologous blood transfusion: a preliminary report.

Normal rats are extremely tolerant to heterologous blood transfusion; however, after subcutaneous injection of noradrenaline, they lose this tolerance and respond with severe thrombohemorrhagic reactions both at the site of injection and in internal organs, particularly the kidney.In histological structure, the topical and general manifestations of this thrombohemorrhagic response are virtually identical with those of the local and general Sanarelli-Shwartzman phenomenon, respectively.Among the blood specimens tested, those of the dog, cat, rabbit, guinea pig, chicken and man were most effective in inducing this type of noradrenaline hypersensitivity. The blood of the duck and hamster as well as homologous rat blood proved to be virtually or completely inefficacious.The possible theoretical and clinical implications of a noradrenaline test for potential blood-borne thrombohemorrhagic factors are briefly discussed.

Animals↗
PubMed1966

Effect of lead acetate on the susceptibility of rats to bacterial endotoxins.

Selye, H. (Université de Montréal, Montreal, Canada), B. Tuchweber, and L. Bertók. Effect of lead acetate on susceptibility of rats to bacterial endotoxins. J. Bacteriol. 91:884-890. 1966.-A single, normally well-tolerated, intravenous injection of lead acetate increases the sensitivity of the rat to the endotoxins of various gram-negative bacteria about 100,000 times above normal. Under the conditions of these experiments, the mortality and organ changes normally produced by the intravenous injection of 100 mug of Escherichia coli endotoxin were essentially the same as those obtained by use of 1 nanogram in lead-sensitized rats. The sensitizing effect of lead acetate for E. coli endotoxin is greatest when the two agents are given simultaneously. However, considerable sensitization is still detectable when endotoxin is injected up to 1 hr before or 7 hr after sensitization with lead. No sensitization was noted when the endotoxin was administered 24 hr before or after lead acetate. Under our experimental conditions, the minimal dose of lead acetate which could still induce significant sensitization to E. coli endotoxin was 1 mg per 100 g of body weight. Although lead acetate induces a high degree of susceptibility to various endotoxins, other reticuloendothelial blocking agents did not acquire unusual toxicity after pretreatment with lead. Finally, none of the other metals or reticuloendothelial blocking agents tested could duplicate the pronounced decrease in endotoxin resistance induced by lead acetate.

Acetates↗
PubMed1966

Predisposition to thrombosis not reflected by the blood coagulogram.

Experiments on rats indicate that thrombosis of large veins can develop while blood coagulability is decreased. Hence, coagulation tests have only a limited value in predicting a thrombotic tendency, although they do show characteristic changes during the formation of thrombi.

Animals↗