Search PubMed⌕ Search

Biomedical subjects

H Schweiger

Publications and source records attributed to H Schweiger.

65 records · Page 4Linked to original sources
PubMed1983

Late phase of liver restoration following partial hepatectomy in phenobarbital-treated rats. I. Effect of preoperative and postoperative phenobarbital treatment on organ weight, protein and DNA content of the normal and the regenerating liver.

Rats were treated with phenobarbital (50 mg/kg) for 7 days prior to or after partial hepatectomy. Liver weight, protein, DNA, and RNA content were determined in liver tissue removed at operation as well as in regenerating liver 7 days later at the time of death. When rats were treated with phenobarbital in the preoperative period an increase in liver weight secondary to cell hyperplasia was observed as compared to livers of rats treated with sodium chloride. The weight of regenerating liver of preoperatively treated rats did not differ from the controls, but protein concentration was significantly higher (P less than or equal to 0.001). When phenobarbital was applied only in the postoperative period, a highly significant (P less than or equal to 0.001) enlargement of the regenerating liver tissue was found secondary to cell hypertrophy without hyperplasia, whereas protein concentration was unchanged. An increased RNA/DNA ratio, however, suggests that further protein synthesis is enhanced. The results show that both preoperative and postoperative phenobarbital treatment aids in hepatic tissue enlargement, though by a different mechanism.

Animals↗
PubMed1983

Late phase of liver restoration following partial hepatectomy in phenobarbital-treated rats. II. Effect of phenobarbital on aspartate aminotransferase, alanine aminotransferase, glutamate dehydrogenase, and UDP-glucuronyltransferase activity.

Rats were treated with 50 mg phenobarbital (PB) per kg body weight for 7 days prior to or after partial hepatectomy. The activities of aspartate aminotransferase, alanine aminotransferase, and glutamate dehydrogenase were measured in the regenerating liver 1 week following liver amputation. UDP-glucuronyl transferase activity was determined at the time of surgery as well as 7 days later at the time of death. Alanine aminotransferase was induced by PB in rats only treated in the postoperative period, while aspartate aminotransferase and glutamate dehydrogenase were not. The activity of UDP-glucuronyl transferase was increased more than twofold by repeated PB treatment in both normal and regenerating liver. After cessation of therapy, however, the enhanced activities returned to a normal level. It is concluded that UDP-glucuronyl transferase activity in regenerating liver is as inducible as in normal rat liver by repeated PB treatment despite incomplete hepatic regeneration. Preoperative PB treatment alone is not sufficient to stimulate the glucuronylating pathway in the late phase of liver regeneration.

Alanine Transaminase↗
PubMedDate not supplied

Results of long-term venacavography study after placement of a Greenfield vena caval filter.

Digital subtraction venacavography (DSV) as a follow-up examination was performed in 46 patients after placement of a standard stainless steel Greenfield vena caval filter (SGF). DSV is an exact method of visualizing the lumen of the inferior vena cava as well as intraluminal or captured thrombi. Eccentric filters with an angulation of more than 15 degrees were found in 8 patients causing a higher risk of pulmonary embolism from smaller emboli and propagating thrombi. Penetration of the caval wall by filter struts was however frequent (41%), without any damage to adjacent structures as demonstrated by CT scans. The long-term caval patency rate was 90%, with 4 cases of caval thrombosis. Two patients with an occluded inferior vena cava showed no venostasis. Although changes of the filter position usually remain asymptomatic, regular follow-up examinations seem necessary to recognize any impairment of the filter's clot trapping efficiency. Filters should only be used in patients with a risk of recurrent pulmonary embolism despite anticoagulation and patients with contraindications to anticoagulation therapy.

Adult↗
PubMedDate not supplied

Digital transvenous angiography in follow-up examinations after carotid reconstruction: early results.

A total of 187 check-up examinations by DVSA were carried out after various types of carotid reconstructions. The results were inconclusive in only 2.7% of the cases. A good or very good postoperative result could be demonstrated in 77.5%. A slight stenosis was present in 16%, a significant stenosis in 2.7% and a complete occlusion of the internal carotid artery in 1.1%. Patch plasty alone showed the best results followed by endarterectomy and endarterectomy with patch plasty. Segmental carotid resections and dilatations led to the poorest results. Most of those cases, where a stenosis recurred, it was already present immediately after the operation and only rarely caused by progression of the basic disease or intimal proliferation. The complication rate of DVSA was low. It is concluded that DVSA is a low risk and reliable method which can routinely be used in the postoperative evaluation of patients with carotid reconstructions.

Acute Kidney Injury↗
PubMedDate not supplied

Surgical treatment of renal artery occlusive disease: long term results.

68 patients were operated on for renal artery occlusive disease. After a mean follow-up of 61 months renovascular hypertension was cured or markedly improved in 79.2%. The results depended mostly on the duration of preexisting hypertension and on the histology of the renal artery lesion. Forty-four months after surgery, 37 reconstructions were examined by angiography. Mostly digital subtraction technique was used. Total occlusion rate was 24%. Patency rates of autogenous vein bypass grafts were similar to prosthetic grafts. It is concluded that prosthetic grafts like PTFE are a reasonable alternative in aortorenal bypass procedures.

Adolescent↗
PubMedDate not supplied

Late results with Dardik-biograft in peripheral arterial surgery.

A total of 117 vascular reconstructions below the inguinal ligament were performed using Dardik's human umbilical vein. The indication for surgery was limb salvage in 91.5%. In 61.5% a previous reconstruction had failed. The distal anastomosis was done with the popliteal artery above the knee in 9 cases, below the knee in 41, and with a tibial or the peroneal artery in 60 cases. The umbilical vein was combined with a prosthesis or the autologous saphenous vein in 20 cases. The cumulative patency rates of all reconstructions were 59.6% after 3, and 46.7% after 6 years. Crural reconstructions had a cumulative patency rate of 52% 3 years after surgery. The main factors influencing patency were the preoperative grade of ischemia, the site of the distal anastomosis and the angiographic run-off. It is concluded that the human umbilical vein is the graft material of choice in long length revascularization whenever the saphenous vein is not available.

Adult↗