[Psychosomatic rehabilitation].
Explore the source record for details and available documents.
Germany↗
Biomedical subjects
H Schulz
Publications and source records attributed to H Schulz.
[Analysis of premature termination in inpatient psychosomatic rehabilitation based on epidemiologic data from two hospital companies].
Premature termination of inpatient psychotherapy can have multiple, mostly negative, effects for patients, therapists, clinics, insurance companies, and employers, but research regarding inpatient settings is still deficient. The analysis of two sets of data of four different rehabilitation clinics from two different hospital companies (2699 and 2215 patients, respectively), aimed at possible predictors and outcomes of premature termination. We found ratios of premature termination of 8.3% and 14.7%, respectively. Especially young patients under 30 years of age and patients with eating and personality disorders were more likely to terminate inpatient treatment prematurely. Treatment outcome as rated by therapists was in significantly fewer cases among premature terminators than among successful terminators improved. The results seem to indicate, that assignment to inpatient psychotherapy can be optimized. For a better understanding of the process of premature termination more theory guided prospective and followup studies are necessary.
Adult↗
[Importance and value of roentgen studies as outcome criteria in rheumatoid arthritis].
In order to evaluate the objectivity and validity of radiographic parameters in rheumatoid arthritis (RA) we studied 56 patients with definite RA. Inter-observer variation was assessed comparing the scorings (Larsen classification) of two independent experienced observers. Total radiographic scores were highly significantly correlated (r = 0.89). Yet, we could not find relevant associations between radiographic findings and clinical outcome parameters (pain, morning stiffness, dexterity, grip strength, and patient's overall assessment). Thus, hand radiographs in RA provide highly reproducible results. Its validity concerning patient outcome, however, has to be interpreted very carefully.
Adult↗
[Diagnosis of pulmonary adenomatosis from the sputum of means of electron microscopy].
Explore the source record for details and available documents.
Animals↗
[Binding of carbonyl-conjugated pentaenes by Saccharomyces cerevisiae yeast cells].
The coefficients of distribution of flavofungin, flavopentin, nigrofungin and brunefungin, antifungal antibiotics, carbonyl-conjugated pentaenes, between water and Saccharomyces cerevisiae cells were determined. The coefficients were shown to increase with a decrease in the cell concentration. Therefore, the minimal concentrations of the antibiotics inhibiting the growth of S. cerevisiae decreased with a fall in the concentration of the yeast cells; the antibiotics with the greatest distribution coefficients had the lowest minimal inhibiting concentrations. The parameters for the binding of the antibiotics by the cells were determined using the equations of Scatchard and Klotz. It is possible that the binding mechanism for flavopentin and brunefungin differs from that for flavofungin and nigrofungin.
Anti-Bacterial Agents↗
Electrocorticogram changes caused by subchronic lead treatment of rats.
Male Wistar rats were treated per os through gavage for 4, 8 and 12 weeks by 80.0, 160.0 and 320.0 mg/kg lead in form of lead acetate. The changes of certain parameters (mean frequency, mean amplitude, ECoG index-the ratio of the slow and fast bands, power spectrum of the frequency bands) of the electrocorticogram (ECoG) recorded from the primary somatosensory, visual and auditory centres of anaesthetized rats were analysed. The data show that all investigated parameters had dose- and time-dependent changes: increased mean frequencies accompanied by decreased mean amplitudes and ECoG-indices. These changes were significant only at the highest, or at the two higher dose groups by the end of the experiment. The data suggest that subchronic, low-level exposure of lead can affect the integrated electrophysiological function of the brain.
Animals↗
Effect of subchronic mercury exposure on electrocorticogram of rats.
Mercury is a neurotoxic compound causing irreversible disorders of the central and peripheral nervous system. In some of the previous human and experimental studies mercury also affected some functional neurological parameters such as EEG, and cortical evoked potentials. In the present study, the effect of subchronic (4, 8, and 12 weeks) relatively low-level (0.4, 0.8, and 1.6 mg/kg mercury in form of HgCl2, per os by gavage) treatment on the basic cortical activity was investigated. Certain parameters of electrocorticogram (ECoG) recorded simultaneously from the primary somatosensory, visual and auditory centres were analyzed. The results showed that mercury had a dose- and time-dependent effect on the examined ECoG parameters, and the changes became significant by the end of the experiment of week 12.
Animals↗
Experimental model studies of pesticide exposure.
The neurotoxic effects of Dimethoate (Dim), Dichlorvos (DDVP) and Methyl-Parathion (MP) respectively were investigated on the central nervous system (CNS) and peripheral nervous system (PNS) of rats after different treatment schedules at the macro and single unit cell level. At the macro investigations 1/25, 1/50 and 1/100 of the respective LD50 values of each pesticide were administered to different groups by gavage daily in the following programs: Pregnancy variation (P) to females from 5th to 15th days of pregnancy; Pregnancy and lactation variation (P+L): to females as above and during lactation for 4 weeks; Pregnancy+lactation+post weaning variation (P+L+P) as above plus to the young male rats (F1 generation) up to 8 weeks. Neurotoxicological investigations were conducted on the F1 rats at the age of 12 weeks. Spontaneous electrocorticograms (ECoG) were recorded on the anesthetized rats from the somatosensory, visual and auditory cortex. Cortical evoked potentials (EP) were recorded from the same areas subsequently. Conduction velocity and refractory periods of the tail nerve was investigated. Treatment by Dim, DDVP and MP during P and P+L of the mothers did not influence the bioelectric activity of the offsprings significantly. The same treatment by the P+L+P programme, resulted in significant changes. Frequency of the spontaneous ECoG waves grew significantly in all dose groups of P+L+P group. Latency time become shorter after somatosensory. light or acoustic stimuli respectively on one hand and the beginning of the of answer of these by the evoked potential (EP) waves on the other hand. Conduction velocity of the tail nerve diminished, refractory periods grew dose dependently and significantly at the P+L+P programs with all the three pesticides. Cortical single unit activity was studied after the i.p administration of 1/5 LD50 of the three organophosphates (OP). The decrease of the firing frequencies was observed. The amplitude of the hippocampal population spikes increased. The changes observed in these studies point toward a higher excitation state of the CNS and a disturbed conduction of the nervous impulses of the peripheral nerves. These results could be taken into consideration when deciding on human contaminations by OP-s.
Animals↗
Developmental neurotoxicological effects of lead and dimethoate in animal experiments.
Neurophysiological changes caused by parallel treatment with inorganic lead and dimethoate (a combination of possible health risk at population level) were investigated in different phases of the ontogenesis. Wistar rats were treated by gavage with lead (80.0 or 320.0 mg/kg); with dimethoate (7.0 or 28.0 mg/kg), or with their combination on days 5-15 of pregnancy, days 5-15 of pregnancy + days 2-28 of lactation (females of P generation), or days 5-15 of pregnancy + days 2-28 of lactation (females of P generation) + 8 weeks after weaning (males of F1 generation). Electrophysiological parameters (electrocorticogram, cortical evoked potentials) of the F1 male rats in the above groups were investigated at the age of 12 weeks. Both spontaneous and evoked electrophysiological phenomena showed dose-, treatment- and combination-dependent changes (e.g. significantly decreased mean amplitude and increased frequency of the electrocorticogram, lengthened latency and duration of the somatosensory, visual and auditory evoked potentials) which seemed to be more pronounced in the groups treated with the combination of lead and dimethoate than in the groups given lead or dimethoate alone. The results indicate that a simultaneous, pre- and postnatal exposure to the neurotoxicants, lead and dimethoate, considerably altered the functioning of the central nervous system.
Animals↗
[Implementation and evaluation of an ambulatory exercise therapy based rehabilitation program for breast cancer patients].
Physical exercise does not only have positive effects on physical fitness but also on mental health. However, there has been little empirical study on effects of rehabilitation programmes based on physical exercise in cancer patients. We conducted a study to examine the interrelation between the participation of breast cancer patients in an exercise rehabilitation training and aspects of quality of life and physical fitness. 28 patients with not metastasized mamma carcinoma participated in a structured exercise rehabilitation program twice a week for ten weeks. Before and after the intervention the patients were asked to fill in questionnaires to assess their quality of life. At the same instants they underwent physical examination and a bicycle ergometry as well as a blood drawing. The training was aimed at changes at the social, emotional, as well as the motor physical level. Pre-post comparisons demonstrated an improvement in quality of life, such as decreased levels of depression and anxiety. Furthermore the women proved to show an obvious increase in physical fitness. Present results support an implementation of an exercise rehabilitation training for breast cancer outpatients.
Adaptation, Psychological↗