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Biomedical subjects

H Schmidt

Publications and source records attributed to H Schmidt.

At least 937 records · Page 52Linked to original sources
PubMed1982

[Primary benign intramural intracavitary cardiac tumors--clinical, diagnostic and therapeutic aspects].

10 cases of benign primary tumours of the heart (5 myxomas of the left atrium, 2 myxomas of the right atrium, 1 right-ventricular endothelioma of the endocardium, 1 left-ventricular pseudorhabdomyoma, 1 tumour of the interventricular septum) are described. The diagnostically decisive method was in 5 cases the heart catheterization with angiocardiography, furthermore in one case each the roentgenogram of the thorax, the echocardiography, the histology of embolic material, the operation as well as the autopsy. The echocardiography was available for 4 patients; in one case it was diagnostically decisive, delivered important additional informations in 2 patients and failed in one patient. With increasing propagation of the echocardiography, which in the opinion of the authors at least in all cases should be used before a planned invasive cardiological diagnosis, is to be reckoned with an improvement of the diagnosis of tumours of the heart and with an increase of the chances of a causal, namely the timely cardiosurgical therapy.

Adult↗
PubMed1982

The pericapsular osteotomy of the os ilium in the treatment of flat acetabula.

The operative correction of the pathological flat acetabulum in congenital dislocation of the hip, myelodysplasia and cerebral palsy can be performed with pelvic osteotomies and acetabuloplasties. In the light of our own experiences gained with different methods we prefer the pericapsular osteotomy of the ilium according to Pemberton since 1971. After the evaluation of the results the advantages of the method compared with other procedures are presented in the light of the improvements of correction and the rate of complication.

Acetabulum↗
PubMed1982

Standardized loading test with protein for the differentiation of phenylketonuria from hyperphenylalaninaemia.

Eighty-nine protein-loading tests were performed in 80 patients with an increased blood phenylalanine concentration. The amount of protein corresponding to 0.18 g phenylalanine/kg body weight per day was calculated and given for 3 days, during which time eight phenylalanine and eight tyrosine blood concentrations were determined. Nine numerical evaluations were checked for discrimination between phenylketonuria and hyperphenylalaninaemia. The two most powerful discriminants were the phenylalanine blood concentration after 72 hours (sample taken in the morning of the 4th day after the beginning of the load) with a limit value of 15 mg/dl (0.91 mmol/l), and the mean value of the 5th to 8th phenylalanine values, also with a limit value of 15 mg/dl. In only eight of the 80 patients would the final diagnosis not have been established by the loading test.

Amino Acid Metabolism, Inborn Errors↗
PubMed1982

Medical education in action: community-based experience and service in Nigeria.

Problem-based, student-centred learning at the Faculty of Health Sciences, Unilorin, Nigeria were incorporated in the overall objectives of producing students with a sense of service and a strong inclination toward broad community care and preventive medicine. The educational programme reflecting this concept was called COBES (community-based experience and service). Twice a year groups of between seven and fourteen students, each accompanied by two to three staff members, settled in a village or other community for 1 month. According to the Faculty's objectives, each group assessed the size of its community (population, areal map) at first. Malnutrition and infectious diseases were selected as the two health problems which were to be studied in depth during the first two COBES placements. Data were collected and analysed by the students from which deductions were made, and at the end of the placement a written report was required by the Faculty. Three learning situations and the experience gained from them by one group of students are reported: (1) What was our community? (2) The nutritional status of children, and (3) Guinea-worm infection. The educational benefits of the programme are discussed and the view of the students is brought out. A correct assessment of students' performances proved difficult. Other problems were related to the experimental situation of COBES, such as insufficient support of the programme by some staff members, the lack of programme structure and logistical shortcomings. The COBES programme, however, set a pattern of medical education which specifically suits Nigerian needs and probably those of other African countries.

Child↗
PubMed1982

Ultrastructural changes in the gut autonomic nervous system following laxative abuse and in other conditions.

Electronmicroscopical studies have been carried out on colonic biopsies from patients with long-term laxative abuse, amyloidosis, diabetic autonomic neuropathy or chronic inflammatory bowel disease. The results of these investigations indicate that submucosal nerve fibres are damaged to an extent dependent upon the intensity of the toxic agent. The main pathological features range from distension or ballooning of axons, reduction of nerve-specific cell structures and increase in lysosomes to a total degeneration of whole nerve fibres. While the degenerative process is uniform, differentiation between disease states can be made on the basis of specific additional lesions such as the presence of typical amyloid fibrils, diabetic microangiopathy or the inflammatory process in inflammatory bowel disease. No changes were found in Whipple's disease or gluten-sensitive enteropathy. It is concluded that the structural alterations may provide a morphological explanation for the disturbances in gut motility, as an intact intramural nervous system is a necessary prerequisite for the regular coordination of normal peristalsis.

Amyloidosis↗
PubMed1982

Oral retinoid in combination with bleomycin, cyclophosphamide, prednisone and transfer factor in mycosis fungoides.

Oral retinoids seem to have been of great benefit in a non-randomized study on advanced mycosis fungoides using two different chemotherapy regimens, one with retinoid, the other without. Both groups also received a 3-drug chemotherapy with bleomycin, cyclophosphamide and prednisone. Complete remission including all signs of lymph-node involvement was found in 8 of 10 patients of the retinoid treated group, while none went into complete remission in the control group. All in the control group died between 3 and 12 months after therapy, whereas all but one in the retinoid treated group are alive. Other treatment differences between the groups were related to the use of transfer factor, topical treatment, and steroid administration. These differences make a final evaluation of the use of retinoids in mycosis fungoides difficult at the present stage. Further studies are needed.

Administration, Oral↗
PubMed1982

[Histochemical analysis of phenoloxidase in leukocytes and lymphocytes isolated from human blood].

Among the cells containing phenoloxidase (POZ) of the human blood there was an evidence of cell forms being morphologically similar to macrophages. Lymphocytes represented no uniform cell fraction. There is a variety of large cells with a different enzyme distribution and activity. All POZ cells can develop a cell form which can be considered as an eye cell. Hypothetically it is connected with the cell generation.

Catechol Oxidase↗
PubMed1982

[Clinical aspects, diagnosis and therapy of acrodermatitis enteropathica].

Acrodermatitis enteropathica is a very rare disease, usually occurring during child age, but also in grown-ups. Symptoms are skin lesions localized periorally and acrally, alopecia, diarrhea and psychic alterations. The disease is caused by zinc deficiency due to malabsorption. The diagnosis can be established by decreased plasma levels of zinc; typical changes of the Paneth cells may be demonstrated by electron microscopy. Substitution by supplying zinc will lead to complete clinical healing.

Acrodermatitis↗
PubMed1982

[On the occurrence of phenoloxidase containing cells (POZ) in nude mice].

Nude mice, who are deficient in T-lymphocytes, were investigated to test, if the T-lymphocytes belong to the POZ or not. The results did not solve the question. But it has been confirmed that the POZ of the tissues are haematopoetic stem cells. Regarding to the obtained PO evidence nude mice are deranged in the PO-cell system. This derangement might be the reason for the fact that these animals tolerate foreign tissues like tumours.

Animals↗